Interleukin 12 [electronic resource] : antitumor activity and immunotherapeutic potential in oncology / Witold Lasek, Radoslaw Zagozdzon ; with a contribution by Marek Jakóbisiak.

Unlimited

Authorized users

Can lend chapters, not whole ebooks

Interleukin 12 [electronic resource] : antitumor activity and immunotherapeutic potential in oncology / Witold Lasek, Radoslaw Zagozdzon ; with a contribution by Marek Jakóbisiak.

9783319469065 (electronic book)
3319469061 (electronic book)
9783319469058
3319469053

Cham, Switzerland : Springer, c2016.

English

1 online resource.

QR185.8.I56

616.07/9

This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However, despite the encouraging results in animal models, only very modest antitumor effects have been confirmed in early clinical trials. Recently, several clinical studies have been initiated in which IL-12 was applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid, and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).

Access limited to authorized users.

Description based on print version record.

SpringerBriefs in immunology.

iPrint version: 3319469053

Online Resources > Ebooks
All Resources