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000762590 019__ $$a881165980
000762590 020__ $$a9783319058795$$q(electronic book)
000762590 020__ $$a3319058797$$q(electronic book)
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000762590 0247_ $$a10.1007/978-3-319-05879-5$$2doi
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000762590 035__ $$aSP(OCoLC)877884439$$z(OCoLC)881165980
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000762590 24500 $$aSphingosine-1-phosphate signaling in immunology and infectious diseases /$$cMichael B.A. Oldstone, Hugh Rosen, editors.
000762590 264_1 $$aCham ;$$aNew York :$$bSpringer,$$c[2014]
000762590 264_4 $$c©2014
000762590 300__ $$a1 online resource (vii, 184 pages) :$$billustrations.
000762590 336__ $$atext$$btxt$$2rdacontent
000762590 337__ $$acomputer$$bc$$2rdamedia
000762590 338__ $$aonline resource$$bcr$$2rdacarrier
000762590 4901_ $$aCurrent topics in microbiology and immunology,$$x0070-217X ;$$vvolume 378
000762590 504__ $$aIncludes bibliographical references and index.
000762590 5050_ $$aThe organization of the sphingosine-1-phosphate signaling system / Hugh Rosen, M. Germana Sanna, Pedro J. Gonzalez-Cabrera and Edward Roberts -- Structural biology of the S1P₁ receptor / Michael A. Hanson and Robert Peach -- Chemical and genetic tools to explore S1P biology / Stuart M. Cahalan -- S1P control of endothelial integrity / Yuquan Xiong and Timothy Hla -- Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen / Tal I. Arnon and Jason G. Cyster -- Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule / Michael B.A. Oldstone and Hugh Rosen -- Sphingosine-1-phosphate and central nervous system / Roland Martin and Mireia Sospedra -- RORs in autoimmune disease / Mi Ra Chang, Hugh Rosen and Patrick R. Griffin.
000762590 506__ $$aAccess limited to authorized users.
000762590 520__ $$aThis volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.
000762590 588__ $$aDescription based on PDF title page (viewed April 22, 2014).
000762590 650_0 $$aImmunopharmacology.
000762590 650_0 $$aSphingosine$$xImmunology.
000762590 650_0 $$aPhosphates$$xImmunology.
000762590 7001_ $$aOldstone, Michael B. A.,$$eeditor.
000762590 7001_ $$aRosen, Hugh$$c(Professor of chemical physiology),$$eeditor.
000762590 77608 $$iPrint version:$$tSphingosine-1-phosphate signaling in immunology and infectious diseases.$$dCham, Switzerland : Springer, [2014]$$z3319058789$$w(DLC)  2014937305$$w(OCoLC)871318817
000762590 830_0 $$aCurrent topics in microbiology and immunology ;$$v378.
000762590 852__ $$bebk
000762590 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-05879-5$$zOnline Access$$91397441.1
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