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Sphingosine-1-phosphate signaling in immunology and infectious diseases / Michael B.A. Oldstone, Hugh Rosen, editors.

9783319058795 (electronic book)
3319058797 (electronic book)
3319058789
9783319058788

Cham ; New York : Springer, [2014]

©2014

English

1 online resource (vii, 184 pages) : illustrations.

10.1007/978-3-319-05879-5 doi

QR1 .E6 v.378

615.3/7

This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.

Includes bibliographical references and index.

Access limited to authorized users.

Description based on PDF title page (viewed April 22, 2014).

Current topics in microbiology and immunology ; 378.

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