Cardiac energy metabolism in health and disease / Gary D. Lopaschuk, Naranjan S. Dhalla, editors.
Lopaschuk, Gary David, 1955- editor.; Dhalla, Naranjan S., editor.
2014
QP114.M48
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Title Cardiac energy metabolism in health and disease / Gary D. Lopaschuk, Naranjan S. Dhalla, editors.
ISBN 9781493912278 (electronic book)
1493912275 (electronic book)
9781493912261
DOI https://doi.org/10.1007/978-1-4939-1227-8
Published New York, NY : Springer, 2014.
Language English
Description 1 online resource (xv, 295 pages) : illustrations.
Other Standard Identifiers 10.1007/978-1-4939-1227-8 doi
Call Number QP114.M48
Dewey Decimal Classification 612.1/73
Summary The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy, and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional, and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction, and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.
Note Includes index.
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed Sept. 4, 2014).
Added Author Lopaschuk, Gary David, 1955- editor.
Dhalla, Naranjan S., editor.
Series Advances in biochemistry in health and disease ; v. 11.
Available in Other Form Print version: 9781493912261
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Part 1. Control of Energy Metabolism
1. A Primer on Carbohydrate Metabolism in the Heart
2. Lipoproteins: A Source of Cardiac Lipids
3. Role of Lipoprotein Lipase in Fatty Acid Delivery to the Heart
4. Control of Myocardial Fatty Acid Uptake
5. Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes
6. Transcriptional Control of Mitochondrial Biogenesis and Maturation
7. Relationship between Substrate Metabolism and Cardiac Efficiency
8. Acetylation in the Control of Mitochondrial Metabolism and Integrity
Part 2. Alteration in Energy Metabolism
9. Adrenergic Control of Cardiac Fatty Acid Oxidation in Diabetes
10. The Myocardial Creatine Kinase System in the Normal, Ischaemic and Failing Heart
11. Fuel Metabolism Plasticity in Pathological Cardiac Hypertrophy and Failure
12. Defects in Mitochondrial Oxidative Phosphorylation in Hearts Subjected to Ischemia-Reperfusion Injury
13. The Role of AMPK in the Control of Cardiac Hypertrophy
14. The Role of Incomplete Fatty Acid Oxidation in the Development of Cardiac Insulin Resistance
Part 3. Optimization of Energy Metabolism
15. Metabolic Therapy for the Ischemic Heart
16. Inhibition of Fatty Acid Oxidation to Treat Heart Failure in Patients
17. Cardiac Metabolic Protection for the Newborn Heart
18. Targeting Transcriptional Control of Fatty Acid Oxidation to Treat Heart Disease.

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