@article{762615,
      recid = {762615},
      author = {Lopaschuk, Gary David, and Dhalla, Naranjan S.,},
      title = {Cardiac energy metabolism in health and disease /},
      pages = {1 online resource (xv, 295 pages) :},
      note = {Includes index.},
      abstract = {The heart has a very high energy demand but very little  energy reserves. In order to sustain contractile function,  the heart has to continually produce a large amount of ATP.  The heart utilizes free fatty acids mainly and  carbohydrates to some extent as substrates for making  energy, and any change in this energy supply can seriously  compromise cardiac function. It has emerged that  alterations in cardiac energy metabolism are a major  contributor to the development of a number of different  forms of heart disease. It is also now known that  optimizing energy metabolism in the heart is a viable and  important approach to treating various forms of heart  disease. Cardiac Energy Metabolism in Health and Disease  describes the research advances that have been made in  understanding what controls cardiac energy metabolism at  molecular, transcriptional, and physiological levels. It  also describes how alterations in energy metabolism  contribute to the development of heart dysfunction, and how  optimization of energy metabolism can be used to treat  heart disease. The topics covered include a discussion of  the effects of myocardial ischemia, diabetes, obesity,  hypertrophy, heart failure, and genetic disorders of  mitochondrial oxidative metabolism on cardiac energetics.  The treatment of heart disease by optimizing energy  metabolism is also discussed, which includes increasing  overall energy production as well as increasing the  efficiency of energy production and switching energy  substrate preference of the heart. This book will be a  valuable source of information to graduate students,  postdoctoral fellows, and investigators in the field of  experimental cardiology as well as biochemists,  physiologists, pharmacologists, cardiologists,  cardiovascular surgeons and other health professionals.},
      url = {http://library.usi.edu/record/762615},
      doi = {https://doi.org/10.1007/978-1-4939-1227-8},
}