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000763170 019__ $$a957464793$$a957680288$$a957738622
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000763170 1001_ $$aBertolaso, Marta,$$eauthor
000763170 24510 $$aPhilosophy of cancer$$h[electronic resource] :$$ba dynamic and relational view /$$cMarta Bertolaso.
000763170 264_1 $$a[Cham] :$$bSpringer,$$c[2016]
000763170 300__ $$a1 online resource.
000763170 336__ $$atext$$btxt$$2rdacontent
000763170 337__ $$acomputer$$bc$$2rdamedia
000763170 338__ $$aonline resource$$bcr$$2rdacarrier
000763170 4901_ $$aHistory, philosophy and theory of the life sciences ;$$vvolume 18
000763170 504__ $$aIncludes bibliographical references.
000763170 506__ $$aAccess limited to authorized users.
000763170 5208_ $$aSince the 1970s, the origin of cancer is being explored from the point of view of the Somatic Mutation Theory (SMT), focusing on genetic mutations and clonal expansion of somatic cells. As cancer research expanded in several directions, the dominant focus on cells remained steady, but the classes of genes and the kinds of extra-genetic factors that were shown to have causal relevance in the onset of cancer multiplied. The wild heterogeneity of cancer-related mutations and phenotypes, along with the increasing complication of models, led to an oscillation between the hectic search of the few key factors that cause cancer and the discouragement in face of a seeming endless complexity . To tame this complexity, cancer research started to avail itself of the tools that were being developed by Systems Biology. At the same time, anti-reductionist voices began claiming that cancer research was stuck in a sterile research paradigm. This alternative discourse even gave birth to an alternative theory: the Tissue Organization Field Theory (TOFT). A deeper philosophical analysis shows limits and possibilities of reductionist and anti-reductionist positions and of their polarization. This book demonstrates that a radical philosophical reflection is necessary to drive cancer research out of its impasses. At the very least, this will be a reflection on the assumptions of different kinds of cancer research, on the implications of what cancer research has been discovering over 40 years and more, on a view of scientific practice that is most able to make sense of the cognitive and social conflicts that are seen in the scientific community (and in its results), and, finally, on the nature of living entities with which we entertain this fascinating epistemological dance that we call scientific research. The proposed Dynamic and Relational View of carcinogenesis is a starting point in all these directions."
000763170 650_0 $$aCancer$$xPhilosophy.
000763170 650_0 $$aMedicine$$xPhilosophy.
000763170 650_0 $$aHealth$$xPhilosophy.
000763170 77608 $$iPrint version:$$z9789402408638$$z9402408630$$w(OCoLC)950953351
000763170 830_0 $$aHistory, philosophy and theory of the life sciences ;$$vv. 18.
000763170 852__ $$bebk
000763170 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-94-024-0865-2$$zOnline Access$$91397441.1
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