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000763396 019__ $$a962435464
000763396 020__ $$a9783319457918$$q(electronic book)
000763396 020__ $$a3319457918$$q(electronic book)
000763396 020__ $$z9783319457895
000763396 0247_ $$a10.1007/978-3-319-45791-8$$2doi
000763396 035__ $$aSP(OCoLC)ocn960701407
000763396 035__ $$aSP(OCoLC)960701407$$z(OCoLC)962435464
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000763396 08204 $$a579.2/6$$223
000763396 24500 $$aBacteriophage applications :$$bhistorical perspective and future potential /$$cJessica Nicastro, Shirley Wong, Zahra Khazaei, Peggy Lam, Jonathan Blay, Roderick A. Slavcev.
000763396 264_1 $$aCham, Switzerland :$$bSpringer,$$c2016.
000763396 300__ $$a1 online resource (vii, 82 pages).
000763396 336__ $$atext$$btxt$$2rdacontent
000763396 337__ $$acomputer$$bc$$2rdamedia
000763396 338__ $$aonline resource$$bcr$$2rdacarrier
000763396 4901_ $$aSpringerBriefs in biochemistry and molecular biology,$$x2211-9353
000763396 504__ $$aIncludes bibliographical references.
000763396 5050_ $$a1 Overview of Bacteriophage Lifecycles and Applications; 1 Introduction; 2 Phage Infection and Life-Cycle; 2.1 Lytic Phage; 2.2 Temperate Phage; 3 Phage Infection Stages; 3.1 Phage Entry; 3.2 DNA Replication; 3.3 Phage Assembly; 3.3.1 Tailed (dsDNA) Phages; 3.3.2 ssDNA Phages; 3.3.3 ssRNA Phages; 4 Hurdles for Phage-Based Therapeutics; References; 2 Phage for Biocontrol; Abstract; 1 Introduction; 2 The Importance of Using Recombinant Phage; 3 Recombinant Phage for the Treatment of Bacterial Infections; 3.1 Escherichia coli (E. coli); 3.2 Staphylococcus aureus (S. aureus)
000763396 5058_ $$a3.3 Chlamydia trachomatis3.4 Pseudomonas aeruginosa (PA); 3.5 Helicobacter pylori (H. pylori); 4 Phage as Drug Delivery Vehicles for the Treatment of Bacterial Infections; 5 Summary; References; 3 Phage Device Coatings; Abstract; 1 Introduction; 2 Biofilms on Medical Devices; 2.1 Contributors to Biofilm Resistance; 3 Alternative Medical Coating Devices; 4 Bacteriophage as Bioactive Coatings; 5 Conclusions; References; 4 Bacteriophages Functionalized for Gene Delivery and the Targeting of Gene Networks; Abstract; 1 Introduction to Phage Mediated Delivery of Genetic Material
000763396 5058_ $$a2 Bacteriophages as Gene Delivery Vehicles3 Phages as Cytotoxic Agents in Eukaryotes; 4 Phages for Delivery to the Central Nervous System; 5 Conclusions; References; 5 Phage Probiotics; Abstract; 1 Introduction: The Gut Microbiota and Probiotics; 2 Roles of the Gut Microbiota and Probiotics; 2.1 Protection Against Pathogens; 2.2 Metabolism; 2.3 Immunomodulation; 2.4 Tissue Development and Maintenance; 3 Bacteriophages in the Gut; 3.1 Phage Population Dynamics; 3.2 Protection Against Pathogens and Immunomodulation; 4 Applications of Phage; 4.1 Lytic Phage Therapy; 4.2 Phage Biotechnology
000763396 5058_ $$a5 ConclusionsReferences; 6 Phage for Biodetection; Abstract; 1 Introduction to Phage-Based Biodetection; 2 Plaque Assays; 2.1 Phage Display for the Improvement of Plaque Assays; 3 Bacteriophage Indicator Organisms (Reporter Phage); 3.1 Fluorescence-Based Assays; 4 Immobilized Phage Particles as Probes for Bacterial Detection; 5 Conclusions; References; 7 Phage-Mediated Immunomodulation; 1 Introduction; 2 Immune Responses to Phage; 2.1 Anti-phage Innate Responses; 2.2 Humoral Immune Reposes to Phage (Anti-phage Antibodies)
000763396 5058_ $$a2.3 Anti-phage Cellular Immunity and the Implications of the Impact of Phage on the Adaptive Responses (T and B Cells)3 Bacteriophage-Based Immune-Pharmaco-Therapies; 3.1 Phage Immunogenicity and Cancer Therapy; 3.1.1 Phage in Tumor Targeting; 3.1.2 Anti-tumor Phage Therapies; 3.2 Bacteriophage Immunotherapy Autoimmune Disorders; 3.3 Bacteriophage Immunotherapy for Drug Addiction; 3.4 Phages and Oxidative Stress; 4 Conclusions; References
000763396 506__ $$aAccess limited to authorized users.
000763396 520__ $$aThis book explores key applications of phage biotechnology and reviews recent advances in phage display technologies. The applications covered were selected on the basis of their significance and representativeness in the field. The small size and enormous diversity of bacteriophages make them ideal candidates for numerous applications across many industries. Since the discovery of phages and the advent of phage display systems, considerable attention has been focused on the development of novel therapeutic and industrial applications. Recent studies combine the genomic flexibility of phages with phage display systems in order to generate modified phages for targeted delivery.
000763396 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed October 14, 2016).
000763396 650_0 $$aBacteriophages.
000763396 7001_ $$aNicastro, Jessica,$$eauthor.
000763396 7001_ $$aWong, Shirley,$$eauthor.
000763396 7001_ $$aKhazaei, Zahra,$$eauthor.
000763396 7001_ $$aLam, Peggy,$$eauthor.
000763396 7001_ $$aBlay, Jonathan,$$eauthor.
000763396 7001_ $$aSlavcev, Roderick A.$$eauthor.
000763396 830_0 $$aSpringerBriefs in biochemistry and molecular biology.
000763396 852__ $$bebk
000763396 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-45791-8$$zOnline Access$$91397441.1
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000763396 980__ $$aEBOOK
000763396 980__ $$aBIB
000763396 982__ $$aEbook
000763396 983__ $$aOnline
000763396 994__ $$a92$$bISE