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Preface; Acknowledgments; Contents; Contributors; 1 Dopamine in REM Sleep Regulation; Abstract; 1 Sleep and REMS; 2 Neural Regulation of REMS; 3 Withdrawal of Inhibition Induces REMS; 4 Dopamine; 5 Location of DA-ergic Neurons; 6 Dopamine Receptors; 7 Intrinsic Regulation of Firing of DA-ergic Neurons-Role of Autoreceptors; 8 DA in Depression; 9 DA in Parkinson's Disease; 10 DA and REMS Behavior Disorder; 11 Involvement of DA-D1 Receptors in Sleep and Wakefulness; 12 DA-ergic System and REMS Regulation; 13 Conclusion; Acknowledgments; References
2 Dopaminergic Transmission and Wake-Promoting Effects of Central Nervous System StimulantsAbstract; 1 History of Dopaminergic Stimulants; 2 Psychostimulants Promote Dopaminergic Neurotransmission; 3 Location of Dopaminergic Cell Groups Controlling Arousal; 4 Midbrain Dopamine Neurons Increase Arousal in Response to Behaviorally Relevant Stimuli; 5 Brainstem Dopaminergic Neurons Have Increased Activity During Wakefulness; 6 Effector Mechanisms of Dopaminergic Control of Arousal in Mammals; 7 Dopaminergic Control of Arousal in Drosophila
8 Effect of Sleep Deprivation on Dopaminergic Neurotransmission9 Dopaminergic Control of Theta, Beta and Gamma Oscillations; 10 Use of Dopaminergic Stimulants to Increase Alertness/Arousal in Sleep Disorders, Disorders of Cortical Activation and Anesthesia; 11 Conclusions; Acknowledgments; References; 3 The Effects of Dopamine Receptor Agonists on the Sleep-Wake Cycle; Abstract; 1 Introduction; 2 The DA Receptor Family and Sleep Modulation; 3 D1 Receptor Agonists and Sleep Modulation; 4 D2 Receptor Agonists and Sleep Control; 5 D3 Receptor Agonists and Sleep-Wake Regulation
6 D4 and D5 Receptor Agonists and Sleep7 Conclusions; Acknowledgments; References; 4 Functional Interactions Between MCHergic and Dopaminergic Neurons: Role in the Control of Wakefulness and Sleep; Abstract; 1 Synopsis of the Dopaminergic System; 2 The Dopaminergic System and Sleep; 3 The Melanin-Concentrating Hormone (MCH); 4 The MCHergic System Promotes Sleep; 5 Interaction Between Dopaminergic and MCHergic Systems in the Control of Behavioral States; 5.1 Evidences from Genetically Modified Animals; 5.2 Effects of MCH on Dopaminergic Neurons
5.3 Interactions Between MCH and DA in the Nucleus Accumbens6 Dopamine Regulates MCHergic Neurons; 7 Lessons from Pathologies; 7.1 Parkinson Disease; 7.2 Major Depressive Disorder; 7.3 Postpartum Emotional Distress; 7.4 Narcolepsy; 7.5 Obesity; 8 Conclusions and Future Directions; References; 5 Modulations of Ventral Tegmental Area (VTA) Dopaminergic Neurons by Hypocretins/Orexins: Implications in Vigilance and Behavioral Control; Abstract; 1 Introduction; 2 Neurobiology of Wakefulness and the DA System; 3 Narcolepsy, a Prototypical Hypersomnia Associated with REM Sleep Abnormalities
2 Dopaminergic Transmission and Wake-Promoting Effects of Central Nervous System StimulantsAbstract; 1 History of Dopaminergic Stimulants; 2 Psychostimulants Promote Dopaminergic Neurotransmission; 3 Location of Dopaminergic Cell Groups Controlling Arousal; 4 Midbrain Dopamine Neurons Increase Arousal in Response to Behaviorally Relevant Stimuli; 5 Brainstem Dopaminergic Neurons Have Increased Activity During Wakefulness; 6 Effector Mechanisms of Dopaminergic Control of Arousal in Mammals; 7 Dopaminergic Control of Arousal in Drosophila
8 Effect of Sleep Deprivation on Dopaminergic Neurotransmission9 Dopaminergic Control of Theta, Beta and Gamma Oscillations; 10 Use of Dopaminergic Stimulants to Increase Alertness/Arousal in Sleep Disorders, Disorders of Cortical Activation and Anesthesia; 11 Conclusions; Acknowledgments; References; 3 The Effects of Dopamine Receptor Agonists on the Sleep-Wake Cycle; Abstract; 1 Introduction; 2 The DA Receptor Family and Sleep Modulation; 3 D1 Receptor Agonists and Sleep Modulation; 4 D2 Receptor Agonists and Sleep Control; 5 D3 Receptor Agonists and Sleep-Wake Regulation
6 D4 and D5 Receptor Agonists and Sleep7 Conclusions; Acknowledgments; References; 4 Functional Interactions Between MCHergic and Dopaminergic Neurons: Role in the Control of Wakefulness and Sleep; Abstract; 1 Synopsis of the Dopaminergic System; 2 The Dopaminergic System and Sleep; 3 The Melanin-Concentrating Hormone (MCH); 4 The MCHergic System Promotes Sleep; 5 Interaction Between Dopaminergic and MCHergic Systems in the Control of Behavioral States; 5.1 Evidences from Genetically Modified Animals; 5.2 Effects of MCH on Dopaminergic Neurons
5.3 Interactions Between MCH and DA in the Nucleus Accumbens6 Dopamine Regulates MCHergic Neurons; 7 Lessons from Pathologies; 7.1 Parkinson Disease; 7.2 Major Depressive Disorder; 7.3 Postpartum Emotional Distress; 7.4 Narcolepsy; 7.5 Obesity; 8 Conclusions and Future Directions; References; 5 Modulations of Ventral Tegmental Area (VTA) Dopaminergic Neurons by Hypocretins/Orexins: Implications in Vigilance and Behavioral Control; Abstract; 1 Introduction; 2 Neurobiology of Wakefulness and the DA System; 3 Narcolepsy, a Prototypical Hypersomnia Associated with REM Sleep Abnormalities