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Acoustical Society of America; Series Preface; Preface 1992; Volume Preface; Contents; Contributors; 1 Perspectives on Auditory Translational Research; Abstract; 1.1 Introduction to the Volume; 1.2 Clinical and Translational Research; 1.3 Translational Efforts Reviewed in This Volume; 1.3.1 The Scientific Continuum and Challenges in Translational Research; 1.3.2 Diagnosis and Treatment of Central Auditory Processing Disorder; 1.3.3 Sudden Hearing Loss; 1.3.4 Noise-Induced Hearing Loss; 1.3.5 Cisplatin-Induced Hearing Loss; 1.3.6 Drugs for Treatment of Tinnitus
1.3.7 A Molecular Therapeutic for Restoration of Auditory Function1.3.8 Cochlear Implants/Infrared Neural Stimulation; 1.4 Summary; References; 2 Current Issues in Clinical and Translational Research in the Hearing Sciences, Audiology, and Otolaryngology; Abstract; 2.1 Translational Research; 2.2 Translational Research in Hearing and Balance; 2.3 The Translational Science Spectrum; 2.3.1 Basic Science; 2.3.2 Preclinical Research; 2.3.3 Clinical Research; 2.3.4 Clinical Implementation; 2.3.5 Public Health; 2.4 Evidence-Based Practice; 2.4.1 Levels of Evidence
2.4.2 Statistical Significance Versus Clinical Significance2.4.3 The Gap Between Knowledge and Action; 2.5 Technology Transfer and the Valley of Death; 2.5.1 Disclosure; 2.5.2 Patents; 2.5.2.1 Patents for Drugs That Mediate Auditory Trauma; 2.5.3 Marketing, Negotiating, and Licensing; 2.6 Summary; 2.7 Closing Comments; Acknowledgments; References; 3 Auditory Processing Disorder: Biological Basis and Treatment Efficacy; Abstract; 3.1 Introduction; 3.2 cABR: Objective Assessment of Central Auditory Function; 3.3 Integrating the cABR into Clinical Practice
3.4 Evaluation of APD and Auditory-Based Learning Impairments3.5 Treatment of APD and Auditory-Based Learning Impairments; 3.6 Aging Effects on Auditory Processing: Spotlight on Hearing in Noise; 3.7 Treatment of Auditory Processing and Speech-in-Noise Perception Deficits in Older Adults; 3.8 Challenges: Evaluating Training Efficacy in Real-World Environments; 3.9 Future Directions; 3.10 Summary; Acknowledgments; References; 4 Sudden Sensorineural Hearing Loss; Abstract; 4.1 Introduction; 4.1.1 Basic Science of SSNHL; 4.1.2 Epidemiology of SSNHL; 4.2 Clinical Presentation
4.2.1 Autoimmune Inner Ear Disease and SSNHL4.2.2 Etiology of Idiopathic SSNHL; 4.2.3 Membranous Breaks; 4.2.4 Viral Infection; 4.2.5 Vascular Occlusion; 4.2.6 Autoimmune Mechanisms; 4.2.7 Cellular Stress Response; 4.3 Prognosis; 4.3.1 Risk Factors; 4.4 Diagnostics and Evaluation; 4.4.1 History and Physical; 4.4.2 Laboratory Testing; 4.4.3 Imaging; 4.5 Treatment; 4.5.1 Steroids; 4.5.2 Hyperbaric Oxygen; 4.5.3 Other Pharmacologic Therapy; 4.5.4 Salvage Therapy; 4.5.5 Counseling and Amplification; 4.5.6 Clinical and Experimental Significance; 4.6 Summary; References
1.3.7 A Molecular Therapeutic for Restoration of Auditory Function1.3.8 Cochlear Implants/Infrared Neural Stimulation; 1.4 Summary; References; 2 Current Issues in Clinical and Translational Research in the Hearing Sciences, Audiology, and Otolaryngology; Abstract; 2.1 Translational Research; 2.2 Translational Research in Hearing and Balance; 2.3 The Translational Science Spectrum; 2.3.1 Basic Science; 2.3.2 Preclinical Research; 2.3.3 Clinical Research; 2.3.4 Clinical Implementation; 2.3.5 Public Health; 2.4 Evidence-Based Practice; 2.4.1 Levels of Evidence
2.4.2 Statistical Significance Versus Clinical Significance2.4.3 The Gap Between Knowledge and Action; 2.5 Technology Transfer and the Valley of Death; 2.5.1 Disclosure; 2.5.2 Patents; 2.5.2.1 Patents for Drugs That Mediate Auditory Trauma; 2.5.3 Marketing, Negotiating, and Licensing; 2.6 Summary; 2.7 Closing Comments; Acknowledgments; References; 3 Auditory Processing Disorder: Biological Basis and Treatment Efficacy; Abstract; 3.1 Introduction; 3.2 cABR: Objective Assessment of Central Auditory Function; 3.3 Integrating the cABR into Clinical Practice
3.4 Evaluation of APD and Auditory-Based Learning Impairments3.5 Treatment of APD and Auditory-Based Learning Impairments; 3.6 Aging Effects on Auditory Processing: Spotlight on Hearing in Noise; 3.7 Treatment of Auditory Processing and Speech-in-Noise Perception Deficits in Older Adults; 3.8 Challenges: Evaluating Training Efficacy in Real-World Environments; 3.9 Future Directions; 3.10 Summary; Acknowledgments; References; 4 Sudden Sensorineural Hearing Loss; Abstract; 4.1 Introduction; 4.1.1 Basic Science of SSNHL; 4.1.2 Epidemiology of SSNHL; 4.2 Clinical Presentation
4.2.1 Autoimmune Inner Ear Disease and SSNHL4.2.2 Etiology of Idiopathic SSNHL; 4.2.3 Membranous Breaks; 4.2.4 Viral Infection; 4.2.5 Vascular Occlusion; 4.2.6 Autoimmune Mechanisms; 4.2.7 Cellular Stress Response; 4.3 Prognosis; 4.3.1 Risk Factors; 4.4 Diagnostics and Evaluation; 4.4.1 History and Physical; 4.4.2 Laboratory Testing; 4.4.3 Imaging; 4.5 Treatment; 4.5.1 Steroids; 4.5.2 Hyperbaric Oxygen; 4.5.3 Other Pharmacologic Therapy; 4.5.4 Salvage Therapy; 4.5.5 Counseling and Amplification; 4.5.6 Clinical and Experimental Significance; 4.6 Summary; References