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Transcriptional control of lineage differentiation in immune cells / Wilfried Ellmeier, Ichiro Taniuchi, editors.

9783319073958 (electronic book)
3319073958 (electronic book)
9783319073941

Cham : Springer, [2014]

©2014

English

1 online resource (viii, 331 pages) : illustrations.

10.1007/978-3-319-07395-8 doi

QR185.8.T2

571.9/66

Insights into the regulation of immune cell lineage differentiation and specification as well as into the control of lineage integrity, stability and plasticity are of fundamental importance to understanding innate and adaptive immune responses. In this volume, leading experts provide an up-to-date and comprehensive overview of recent advances in the transcriptional control mechanisms and transcription factor networks that regulate these processes in a variety of different immune cell lineages. The chapters cover the regulation of T versus B cell lineage choice, discuss early B cell development and pre-B cell leukemia prevention, address transcriptional control mechanisms during Th differentiation, in regulatory T cells and iNKT cells, detail genomic switches in helper cell fate choice and plasticity, and highlight the role of the BTB-zinc finger family of transcription factors in T cells. Moreover, the chapters discuss transcriptional networks in DCs, NK cells and in innate lymphoid cells. Together, the reviews illustrate key transcriptional control mechanisms that regulate the development and function of immune cells and demonstrate the impressive advances made over the last decade.

Includes bibliographical references and index.

Access limited to authorized users.

Online resource; title from PDF title page (SpringerLink, viewed September 19, 2014).

Current topics in microbiology and immunology ; v.381.

Print version: 9783319073941

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