Linked e-resources
Details
Table of Contents
Contributors; Part I: Disruption of Thyroid Hormone Action at Molecular Level; Chapter 1: Mechanisms forßThyroid Hormone Action inßtheßCNS; 1.1 Introduction; 1.2 The Hypothalamic/Pituitary/Thyroid Axis; 1.3 TH Synthesis; 1.4 TH Transport inßCirculation; 1.5 TH Transporters; 1.6 TH Deiodinases; 1.7 Thyroid Hormone Receptors; 1.8 TR Binding toßThyroid Hormone Response Elements; 1.9 TR-Mediated Transcriptional Activity; 1.10 Basal Repression ofßTranscription by TRs; 1.11 Transcriptional Activation by TRs; 1.12 Negative Transcriptional Regulation by TRs; 1.12.1 TR Action inßtheßCNS.
1.12.2 Molecular Targets ofßTRs inßtheßCNS1.13 Non-genomic Actions ofßTH; 1.14 Summary; References; Chapter 2: Deiodinase andßBrain Development; 2.1 Introduction; 2.1.1 Thyroid Hormone Metabolism; 2.1.2 Iodothyronine Deiodinases andßCentral Nervous System; 2.1.3 Thyroid Hormones inßNeurological Development; 2.1.4 Iodothyronine Deiodinases inßNeurological Development; References; Chapter 3: Brominated Organohalogens andßNeurodevelopment: Different Mechanisms, Same Consequence; 3.1 Introduction; 3.2 Thyroid Hormone Signaling andßPBDE; 3.3 Neurobehavioral Effects ofßPBDE.
3.4 Mechanism ofßPBDE Action3.4.1 In Vivo Evidence ofßPBDE Action; 3.4.2 In Vitro Evidence ofßPBDE Action; 3.5 Summary; References; Chapter 4: Perinatal Infection-Associated Changes inßThyroid Hormone Status, Gut Microbiome, andßThyroid Hormone-Mediated Neurodevelopment; 4.1 Introduction; 4.2 Conclusions; References; Chapter 5: Disruption ofßFeedback Regulation ofßThyroid Hormone Synthesis/Secretion andßBrain Development; 5.1 Introduction; 5.2 Development ofßtheßHypothalamus andßtheßPituitary Gland; 5.2.1 The Hypothalamus; 5.2.2 The Pituitary Gland.
5.2.3 Differentiation ofßtheßAnterior Pituitary Cells5.2.4 The Effect ofßPrimary Hypothyroidism onßtheßHypothalamic-Pituitary Development; 5.3 Hormones andßReceptors inßtheßHypothalamic-Pituitary-Thyroid Axis; 5.3.1 TRH; 5.3.2 TRH Receptor; 5.3.3 TSH; 5.3.4 TSH Receptor; 5.3.5 Thyroid Hormone andßThyroid Hormone Receptor; 5.4 Epidemiology ofßCongenital Central Hypothyroidism; 5.5 Etiology ofßCongenital Central Hypothyroidism; 5.5.1 Pituitary Adenoma; 5.5.2 Abnormalities Related toßPituitary Development; 5.5.3 Gestational Hyperthyroidism; 5.5.4 Genetic Mutations.
5.6 Neuronal Symptoms inßCongenital Central Hypothyroidism5.7 Experimental Approaches Using Animal Models; 5.8 Potential Roles ofßTRH inßtheßBrain BesidesßtheßRegulation ofßThyroid Hormone Homeostasis; 5.9 Perspectives; References; Part II: Animal Models to Study Thyroid Hormone Disruption on Neurodevelopment; Chapter 6: Animal Models toßStudy Thyroid Hormone Action inßNeurodevelopment; 6.1 Animal Models forßThyroid Dysgenesis or Thyroid Dyshormonogenesis; 6.1.1 Animal Models forßThyroid Dysgenesis; 6.1.2 Animal Models forßThyroid Dyshormonogenesis; Antithyroid Drug-Induced Hypothyroidism.
Mutant Animals Showing Thyroid Dyshormonogenesis.
1.12.2 Molecular Targets ofßTRs inßtheßCNS1.13 Non-genomic Actions ofßTH; 1.14 Summary; References; Chapter 2: Deiodinase andßBrain Development; 2.1 Introduction; 2.1.1 Thyroid Hormone Metabolism; 2.1.2 Iodothyronine Deiodinases andßCentral Nervous System; 2.1.3 Thyroid Hormones inßNeurological Development; 2.1.4 Iodothyronine Deiodinases inßNeurological Development; References; Chapter 3: Brominated Organohalogens andßNeurodevelopment: Different Mechanisms, Same Consequence; 3.1 Introduction; 3.2 Thyroid Hormone Signaling andßPBDE; 3.3 Neurobehavioral Effects ofßPBDE.
3.4 Mechanism ofßPBDE Action3.4.1 In Vivo Evidence ofßPBDE Action; 3.4.2 In Vitro Evidence ofßPBDE Action; 3.5 Summary; References; Chapter 4: Perinatal Infection-Associated Changes inßThyroid Hormone Status, Gut Microbiome, andßThyroid Hormone-Mediated Neurodevelopment; 4.1 Introduction; 4.2 Conclusions; References; Chapter 5: Disruption ofßFeedback Regulation ofßThyroid Hormone Synthesis/Secretion andßBrain Development; 5.1 Introduction; 5.2 Development ofßtheßHypothalamus andßtheßPituitary Gland; 5.2.1 The Hypothalamus; 5.2.2 The Pituitary Gland.
5.2.3 Differentiation ofßtheßAnterior Pituitary Cells5.2.4 The Effect ofßPrimary Hypothyroidism onßtheßHypothalamic-Pituitary Development; 5.3 Hormones andßReceptors inßtheßHypothalamic-Pituitary-Thyroid Axis; 5.3.1 TRH; 5.3.2 TRH Receptor; 5.3.3 TSH; 5.3.4 TSH Receptor; 5.3.5 Thyroid Hormone andßThyroid Hormone Receptor; 5.4 Epidemiology ofßCongenital Central Hypothyroidism; 5.5 Etiology ofßCongenital Central Hypothyroidism; 5.5.1 Pituitary Adenoma; 5.5.2 Abnormalities Related toßPituitary Development; 5.5.3 Gestational Hyperthyroidism; 5.5.4 Genetic Mutations.
5.6 Neuronal Symptoms inßCongenital Central Hypothyroidism5.7 Experimental Approaches Using Animal Models; 5.8 Potential Roles ofßTRH inßtheßBrain BesidesßtheßRegulation ofßThyroid Hormone Homeostasis; 5.9 Perspectives; References; Part II: Animal Models to Study Thyroid Hormone Disruption on Neurodevelopment; Chapter 6: Animal Models toßStudy Thyroid Hormone Action inßNeurodevelopment; 6.1 Animal Models forßThyroid Dysgenesis or Thyroid Dyshormonogenesis; 6.1.1 Animal Models forßThyroid Dysgenesis; 6.1.2 Animal Models forßThyroid Dyshormonogenesis; Antithyroid Drug-Induced Hypothyroidism.
Mutant Animals Showing Thyroid Dyshormonogenesis.