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000764411 019__ $$a963932062$$a966239065
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000764411 08204 $$a615.7/8$$223
000764411 08204 $$a610
000764411 24500 $$aMelatonin, neuroprotective agents and antidepressant therapy /$$cFrancisco López-Muñoz, Venkataramanujam Srinivasan, Domenico de Berardis, Cecilio Álamo, Takahiro A. Kato, editors.
000764411 260__ $$aNew Delhi :$$bSpringer,$$c2016.
000764411 300__ $$a1 online resource
000764411 336__ $$atext$$btxt$$2rdacontent
000764411 337__ $$acomputer$$bc$$2rdamedia
000764411 338__ $$aonline resource$$bcr$$2rdacarrier
000764411 504__ $$aIncludes bibliographical references and index.
000764411 5050_ $$aPreface; Contents; Contributors; 1: History ofßPineal Gland asßNeuroendocrine Organ andßtheßDiscovery ofßMelatonin; 1.1 Introduction; 1.2 Galen's Conarium: TheßPineal Gland inßtheßClassic Antiquity; 1.3 The Valvular Function ofßtheßPineal Organ andßtheßThree Cell Medieval Theory; 1.4 The Pineal Gland inßIts Anatomical Context; 1.5 The Pineal Gland asßtheßSeat ofßtheßSoul in the Philosophical andßPhysiological Cartesian Approaches; 1.6 A Century andßaßHalf ofßDecline inßtheßScientific Understanding ofßtheßPineal Gland.
000764411 5058_ $$a1.7 The Resurgence ofßInterest inßtheßPineal Gland andßtheßKnowledge ofßIts Structure andßInner Nature1.8 The Pineal Gland asßanßEndocrine Organ; References; 2: Bibliometric Study ofßScientific Research onßMelatonin During theßLast 25ßYears; 2.1 Introduction; 2.2 Method; 2.2.1 Data Sources; 2.2.2 Bibliometric Indicators; 2.2.3 Document Allocation; 2.3 Results; 2.4 Discussion; References; 3: Neuroimaging ofßtheßPineal Gland: Focus onßPrimary Insomnia; 3.1 Background; 3.2 Neuroimaging ofßtheßPineal Gland; 3.2.1 Pineal Gland Volume; 3.2.2 Pineal Calcifications; 3.2.3 Pineal Cysts.
000764411 5058_ $$a3.3 Melatonin, Pineal Gland Volume, andßInsomnia Conclusion; References; 4: Melatonin: Basic andßClinical Aspects; 4.1 Introduction; 4.2 Melatonin Biosynthesis inßPineal Gland withßRegulation ofßSecretion; 4.3 Melatonin Synthesis inßOther Tissues andßOrgans; 4.4 Melatonin Receptors; 4.5 Signal Transduction Pathways; 4.5.1 Receptor-Dependent Mechanisms; 4.5.2 Receptor-Independent Mechanisms; 4.6 Physiological Actions withßIts Therapeutic Potentials; 4.7 Concluding Remarks; References; 5: Melatonin andßMelatonin Receptors inßNeuroprotection; 5.1 Introduction.
000764411 5058_ $$a5.2 What Do WeßKnow AboutßtheßMelatonin?5.3 Biosynthesis andßMetabolism ofßMelatonin; 5.4 Melatonin asßanßAntioxidant Agent; 5.5 The Neuroprotective Effects ofßMelatonin; 5.5.1 Effects ofßMelatonin onßtheßNeurodegenerative Events inßtheßCentral Nervous System; 5.6 The Affect Mechanisms ofßMelatonin andßIts Receptors; 5.7 Melatonin Receptors: AßPerspective; Conclusion; References; 6: Melatonin Supplementation inßNeurodegenerative Diseases: Current Status; 6.1 Introduction; 6.2 Oxidative Mechanisms Involved inßNeuronal Degeneration; 6.3 Role ofßMelatonin inßNeurodegenerative Diseases.
000764411 5058_ $$a6.3.1 Melatonin inßAlzheimer's Disease6.3.2 Melatonin inßParkinson's Disease; 6.3.3 Melatonin inßHuntington Disease; 6.3.4 Melatonin andßAmyotrophic Lateral Sclerosis; 6.4 Perspective; References; 7: Therapeutic Potential ofßMelatonin inßCombination withßOther Drugs Against Neurodegeneration; 7.1 Introduction; 7.2 Alzheimer's Disease; 7.3 Parkinson's Disease; 7.4 Huntington's Disease; 7.5 Amyotrophic Lateral Sclerosis; Conclusion; References; 8: Melatonin, aßNeuroprotective Agent: Relevance forßStress-ƯInduced Neuropsychiatric Disorders; 8.1 Introduction.
000764411 506__ $$aAccess limited to authorized users.
000764411 520__ $$aThis work is a guidebook for clinicians who are involved in treating depressive patients and also serves the research scientists who are working on the psychopharmacological mechanisms of antidepressant actions and psychopathological mechanisms underlying mood disorders. Mood disorders such as major depressive disorder (MDD), bipolar disorder (BPD) and seasonal affective disorder (SAD) are the most disabling disorders that are among the most expensive of all medical illnesses. The pathophysiology of mood disorders is very complex and involves many mechanisms like circadian rhythm disruption, sleep abnormalities, melatonin rhythm abnormalities and alterations in melatonin receptor mechanisms, abnormalities in monoaminergic neurotransmitter mechanisms, glutamatergic release mechanisms, hippocampal neurogenesis, and abnormal immune and cytokine release mechanisms. Many antidepressants that are in clinical use today including the recently introduced novel agents like agomelatine or other antidepressants cause clinical remission by resynchronizing disrupted circadian rhythms and melatonin receptor functions, enhancing monoaminergic neurotransmission, promoting hippocampal neurogenesis, and regulating immune mechanisms. This book explains various etiological factors that are involved in the pathogenesis of mood disorders and the mechanisms of therapeutic actions of antidepressants including the recently introduced agomelatine and other antidepressants that exhibit rapid onset of action with greater efficacy and fewer side effects.
000764411 650_0 $$aMelatonin.
000764411 650_0 $$aMelatonin$$xTherapeutic use.
000764411 650_0 $$aAntidepressants.
000764411 650_0 $$aMedicine.
000764411 650_0 $$aInternal medicine.
000764411 650_0 $$aNeurology.
000764411 650_0 $$aPsychopharmacology.
000764411 7001_ $$aSrinivasan, V.$$q(Venkataramanujan),$$eeditor.
000764411 7001_ $$aLópez-Muñoz, Francisco,$$eeditor.
000764411 7001_ $$aDe Berardis, Domenico,$$eeditor.
000764411 7001_ $$aÁlamo, Cecilio,$$eeditor.
000764411 7001_ $$aKato, Takahiro A.,$$eeditor.
000764411 77608 $$iPrint version:$$tMelatonin, neuroprotective agents and antidepressant therapy.$$dNew Delhi : Springer, 2016$$z9788132228011$$z8132228014$$w(OCoLC)944473974
000764411 852__ $$bebk
000764411 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-81-322-2803-5$$zOnline Access$$91397441.1
000764411 909CO $$ooai:library.usi.edu:764411$$pGLOBAL_SET
000764411 980__ $$aEBOOK
000764411 980__ $$aBIB
000764411 982__ $$aEbook
000764411 983__ $$aOnline
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