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GABAB Receptor / edited by Giancarlo Colombo.

Colombo, Giancarlo, editor.
2016
QP563.G32
Available Online
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Title
GABAB Receptor / edited by Giancarlo Colombo.
ISBN
9783319460444 (electronic book)
3319460447 (electronic book)
9783319460420
3319460420
DOI
https://doi.org/10.1007/978-3-319-46044-4
Published
Cham : Springer International Publishing : Imprint : Humana Press, 2016.
Language
English
Description
1 online resource (xx, 385 pages) : illustrations.
Item Number
10.1007/978-3-319-46044-4 doi
Call Number
QP563.G32
Dewey Decimal Classification
612.8
Summary
An up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. This overview provides a translational perspective on the potential of the GABA B receptor pharmacology.
Bibliography, etc. Note
Includes bibliographical references.
Access Note
Access limited to authorized users.
Digital File Characteristics
text file PDF
Added Author
Colombo, Giancarlo, editor.
Series
Receptors ; 29.
Available in Other Form
Print version: 9783319460420
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Online Access
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1. Historical Perspectives on the GABAB Receptor
Section 1. Chemistry
2. Chemistry of GABAB Receptor Ligands: Focus on Agonists and Antagonists
3. Chemistry of GABAB Receptor Ligands: Focus on Positive Allosteric Modulators
Section 2. Molecular Biology, Biochemistry, & Physiology
4. Molecular Structure and Trafficking of the GABAB Receptor
5. Distribution and Localization of the GABAB Receptor
6. Activation Mechanism and Allosteric Properties of the GABAB Receptor
7. Modulation of Neurotransmission by the GABAB Receptor
8. GABAB Receptor Functions In The Mesolimbic Dopamine System
Section 3. Pharmacology
9. Drug Discrimination Studies for Investigations on the Mechanisms of Action of GABAB Receptor Ligands
10. Targeting the GABAB Receptor for the Treatment of Epilepsy
11. Targeting the GABAB Receptor for the Treatment of Pain
12. Targeting the GABAB Receptor for the Treatment of Psychiatric Disorders
13. Targeting the GABAB Receptor for the Treatment of Fragile X Syndrome and Autism Spectrum Disorders
14. Targeting the GABAB Receptor for the Treatment of Substance Use Disorder
15. Targeting the GABAB Receptor for the Treatment of Alcohol Use Disorder
16. Targeting GABAB Receptors for the Treatment of Gastroesophageal Reflux Disease and Chronic Cough
17. Baclofen: Therapeutic Use and Potential of the Prototypic GABAB Receptor Agonist
18. Allosteric Modulators: The New Generation of GABAB Receptor Ligands
19. GABAB Receptor Antagonists as Cognition Enhancers.

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