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000772400 019__ $$a971059724
000772400 020__ $$a9783319480664$$q(electronic book)
000772400 020__ $$a3319480669$$q(electronic book)
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000772400 0247_ $$a10.1007/978-3-319-48066-4$$2doi
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000772400 050_4 $$aRC280.M37
000772400 08204 $$a616.99/47706$$223
000772400 08204 $$a610
000772400 1001_ $$aRotte, Anand.
000772400 24510 $$aImmunotherapy of melanoma /$$cAnand Rotte, Madhuri Bhandaru.
000772400 264_1 $$aCham, Switzerland :$$bSpringer,$$c2016.
000772400 300__ $$a1 online resource
000772400 336__ $$atext$$btxt$$2rdacontent
000772400 337__ $$acomputer$$bc$$2rdamedia
000772400 338__ $$aonline resource$$bcr$$2rdacarrier
000772400 347__ $$atext file$$bPDF$$2rda
000772400 504__ $$aIncludes bibliographical references.
000772400 5050_ $$aMelanoma; 1 Melanoma-Introduction, History and Epidemiology; Abstract; 1.1 Introduction; 1.1.1 Basics of Structure and Functions of Skin; 1.1.2 Melanocytes; 1.1.3 Melanoma-Definition; 1.1.4 Prominent People Who Were Diagnosed with Melanoma; 1.2 History; 1.2.1 Initial Descriptions of Melanoma; 1.2.2 Hereditary Nature of Melanoma; 1.2.3 Descriptions of Uveal Melanoma; 1.2.4 Introduction of Term 'Melanoma'; 1.2.5 Descriptions of Association Between Melanoma and Skin Color; 1.2.6 Introduction of Clark's Level and Breslow Thickness.
000772400 5058_ $$a1.2.7 Descriptions of Associations Between Sunlight, MC1R Mutations and Melanoma1.2.8 Description of Familial Atypical Multiple Mole Melanoma and CDKN2A Mutations; 1.2.9 Discovery of Ras Oncogenes and Their Relationship with Melanoma; 1.2.9.1 Epidemiology; References; 2 Melanoma-Diagnosis, Subtypes and AJCC Stages; Abstract; 2.1 Introduction; 2.2 Signs and Symptoms of Melanoma; 2.3 Diagnosis; 2.3.1 Dermoscopy; 2.3.2 Total-Body Photography; 2.3.3 In Vivo Reflectance Confocal Laser Microscopy; 2.3.4 Histopathology; 2.3.5 Molecular Diagnosis; 2.4 Types of Melanoma.
000772400 5058_ $$a2.4.1 Superficial Spreading Melanoma2.4.2 Lentigo Maligna Melanoma; 2.4.3 Acral Lentiginous Melanoma; 2.4.4 Nodular Melanoma; 2.4.5 Desmoplastic Melanoma; 2.4.6 Nevoid Melanoma; 2.4.7 Verrucous Melanoma; 2.5 Melanoma Stages; 2.5.1 Clark Classification; 2.5.2 Breslow Classification; 2.5.3 TNM (Tumor, Node and Metastasis) Classification; 2.5.4 Melanoma Staging-AJCC System; References; 3 Etiology; Abstract; 3.1 Introduction; 3.2 UV Light and Sun Exposure; 3.2.1 Sunlight Exposure and DNA Damage; 3.2.2 Repair of UV Induced DNA Damage; 3.2.3 Xeroderma Pigmentosum; 3.3 Family History.
000772400 5058_ $$a3.4 Familial Atypical Multiple Mole Melanoma Syndrome3.5 Skin and Hair Color; 3.6 Susceptibility Genes; 3.6.1 Cyclin-Dependent Kinase Inhibitor 2A (CDKN2A); 3.6.2 Cyclin Dependent Kinase 4 (CDK4); 3.6.3 Melanocortin 1 Receptor (MC1R); 3.6.4 Microphthalmia-associated Transcription Factor (MITF); 3.7 Aberrant Signaling Pathways; 3.7.1 c-KIT or KIT; 3.7.2 RAS Family of Proteins; 3.7.3 BRAF Activation; References; 4 Melanoma-Treatment; Abstract; 4.1 Evolution of Treatment in 19th and 20th Centuries; 4.2 Surgery; 4.2.1 Primary Melanoma; 4.2.2 Regional Lymph Node Metastasis.
000772400 5058_ $$a4.2.3 Metastatic Melanoma4.3 Adjuvant Therapy; 4.3.1 Adjuvant Immunotherapy; 4.3.2 Adjuvant Radiation Therapy; 4.4 Chemotherapy; 4.4.1 Alkylating Agents (Dacarbazine/Temozolomide); 4.4.2 Biochemotherapy; 4.5 Targeted Therapy; 4.5.1 BRAFV600E Inhibitors; 4.5.2 MEK Inhibitors; 4.6 Immunotherapy; 4.7 Recommendations (2013)ßfrom Society of Immunotherapy of Cancer for Stage IV Melanoma; References; Tumor Immunology; 5 Overview of Immune System; Abstract; 5.1 Introduction; 5.2 Innate Immune System; 5.2.1 Neutrophils; 5.2.2 Complement System; 5.2.3 Eosinophils; 5.2.4 Mast Cells.
000772400 506__ $$aAccess limited to authorized users.
000772400 520__ $$aThis book focusses on the different types of immunotherapeutics that are currently being used and developed for the treatment of melanoma. In recent years, immunotherapy has revolutionized the treatment of metastatic melanoma and other types of cancer. Discussing treatment options for melanoma and the success of immunotherapy along with the challenges of immunotherapy, this book covers epidemiology, susceptibility genes, and treatment recommendations from Society for Immunotherapy of Cancer, as well as immune based therapies such as aldesleukin, Intron-A, Sylatron, Yervoy, Opdivo, Keytruda, Imlygic, DC vaccines and adoptive cell therapy. The detailed information included on the key immune cells involved in anti-tumor immune response and immune-inhibitory mechanisms in tumor microenvironment will aid the understanding of tumor immunology. Both academic as well as industry-based researchers, developing novel anti-cancer therapies, will also benefit from the details of promising molecular targets and immunotherapeutic strategies under investigation. With 132 illustrations including synopsis tables for important information, over 1200 references (majority of which are openly accessible) and details of more than 150 ongoing clinical trials, this book is a valuable source of information for health care providers as well as cancer biologists interested in learning about melanoma and the significant advances made by immunotherapy.
000772400 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed February 2, 2017).
000772400 650_0 $$aMelanoma$$xImmunotherapy.
000772400 650_0 $$aMelanoma$$xImmunological aspects.
000772400 650_0 $$aMedicine.
000772400 650_0 $$aCancer$$xResearch.
000772400 650_0 $$aOncology.
000772400 7001_ $$aBhandaru, Madhuri.
000772400 77608 $$iPrint version:$$z9783319480657
000772400 852__ $$bebk
000772400 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-48066-4$$zOnline Access$$91397441.1
000772400 909CO $$ooai:library.usi.edu:772400$$pGLOBAL_SET
000772400 980__ $$aEBOOK
000772400 980__ $$aBIB
000772400 982__ $$aEbook
000772400 983__ $$aOnline
000772400 994__ $$a92$$bISE