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000772401 020__ $$a9783319492841$$q(electronic book)
000772401 020__ $$a3319492845$$q(electronic book)
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000772401 035__ $$aSP(OCoLC)ocn967224584
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000772401 24500 $$aHow to overcome the antibiotic crisis :$$bfacts, challenges, technologies and future perspectives /$$cMarc Stadler, Petra Dersch, editors.
000772401 264_1 $$aCham, Switzerland :$$bSpringer,$$c[2016]
000772401 300__ $$a1 online resource.
000772401 336__ $$atext$$btxt$$2rdacontent
000772401 337__ $$acomputer$$bc$$2rdamedia
000772401 338__ $$aonline resource$$bcr$$2rdacarrier
000772401 4901_ $$aCurrent topics in microbiology and immunology,$$x0070-217X ;$$vvolume 398
000772401 504__ $$aIncludes bibliographical references.
000772401 5050_ $$aTackling threats and future problems of multidrug-resistant bacteria.-Emergence and spread of antimicrobial resistance: recent insights from bacterial population genomics -- Epidemiology of Staphylococcus aureus nasal carriage patterns in the community -- Diagnostics and resistance profiling of bacterial pathogens -- Use of antibiotics and antimicrobial resistance in veterinary medicine as exemplified by the swine pathogen Streptococcus suis.-Antibiotics and the intestinal microbiome: individual responses, resilience of the ecosystem and the susceptibility to infections -- Anti-virulence strategies to target bacterial infections -- Strategies to block bacterial pathogenesis by interference with motility and chemotaxis -- New horizons in the development of novel needle-free immunization strategies to increase vaccination efficacy -- History of antibiotics research -- Actinobacteria and Myxobacteria -- Two of the most important bacterial resources for novel antibiotics -- Exploitation of fungal biodiversity for discovery of novel antibiotics -- Strategies for the discovery and development of new antibiotics from natural products: Three Case Studies -- New structural templates for clinically validated and novel targets in antimicrobial drug research and development -- Synthesis of antibiotics -- Antibiotics clinical development and pipeline -- Anti-infectives in drug delivery -- overcoming the Gram-negative bacterial cell envelope.
000772401 506__ $$aAccess limited to authorized users.
000772401 520__ $$aThis volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the "bad bugs" are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.
000772401 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed February 1, 2017).
000772401 650_0 $$aPharmaceutical microbiology.
000772401 650_0 $$aAntibiotics.
000772401 650_0 $$aDrug resistance in microorganisms.
000772401 650_0 $$aMedicine.
000772401 650_0 $$aMedical microbiology.
000772401 650_0 $$aPharmacology.
000772401 650_0 $$aPharmaceutical chemistry.
000772401 650_0 $$aBacteriology.
000772401 7001_ $$aStadler, Marc,$$eeditor.
000772401 7001_ $$aDersch, Petra,$$eeditor.
000772401 830_0 $$aCurrent topics in microbiology and immunology ;$$vv. 398.
000772401 852__ $$bebk
000772401 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-49284-1$$zOnline Access$$91397441.1
000772401 909CO $$ooai:library.usi.edu:772401$$pGLOBAL_SET
000772401 980__ $$aEBOOK
000772401 980__ $$aBIB
000772401 982__ $$aEbook
000772401 983__ $$aOnline
000772401 994__ $$a92$$bISE