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000772538 019__ $$a969884865
000772538 020__ $$a9783319429342$$q(electronic book)
000772538 020__ $$a3319429345$$q(electronic book)
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000772538 08204 $$a616.99/40695$$223
000772538 08204 $$a610
000772538 24500 $$aCurrent strategies in cancer gene therapy /$$cWolfgang Walther, editor.
000772538 260__ $$aCham :$$bSpringer,$$c2017.
000772538 300__ $$a1 online resource (124 pages)
000772538 336__ $$atext$$btxt$$2rdacontent
000772538 337__ $$acomputer$$bc$$2rdamedia
000772538 338__ $$aonline resource$$bcr$$2rdacarrier
000772538 4901_ $$aRecent Results in Cancer Research ;$$vv. 209
000772538 5050_ $$a1 p53 Replacement Therapy for Cancer; Abstract; 1 Introduction; 2 p53-Mediated Cell Survival and Cell Death Signaling Pathways; 3 p53 Replacement Therapy; 3.1 Cationic Liposome Complex with a DNA Plasmid; 3.2 Replication-deficient Adenovirus Vector; 3.3 Replication-competent Adenovirus Vector; 3.4 Protein Transduction Therapy; 4 Bystander Effect of p53 Replacement Therapy; 5 Conclusion; Acknowledgments; References; 2 Retroviral Vectors for Cancer Gene Therapy; Abstract; 1 Introduction; 2 Anticancer Strategies Based on CARs and TCR; 2.1 T Cells; 2.2 T Precursor Cells; 2.3 NK Cells
000772538 5058_ $$a2.4 Induced Pluripotent Stem Cells (iPSC)3 Gene Therapy; 3.1 O-6-Methylguanine DNA Methyltransferase (MGMT); 3.2 Cytidine Deaminase and the Multidrug Resistance Gene 1 (MDR1); 3.3 Suicide Gene Strategies; 3.4 Genome Editing Strategies; 4 Conclusions; Acknowledgments; References; 3 Minicircle-Based Engineering of Chimeric Antigen Receptor (CAR) T Cells; Abstract; 1 Introduction; 1.1 MC DNA as Minimalistic Expression Cassette; 1.2 Non-viral Gene-Transfer Through Sleeping Beauty Transposition; 1.3 Principles of CAR Design; 1.4 Gene-Transfer Strategies and Clinical Experience with CAR T Cells
000772538 5058_ $$a2 Methodologies of SB-Minicircle and CAR T Cell Manufacturing2.1 Construction of Transposable MC Vectors; 2.2 Manufacturing of MC DNA; 2.3 Engineering of CAR T Cells; 2.4 Functional Testing of CAR T Cells; 3 Antitumor Function of Minicircle Engineered CAR T Cells; 3.1 Characterization of MC DNA; 3.2 Gene-Transfer Rate and Integration Profile; 3.3 Functional Characterization of CAR T Cells; 4 Future Perspectives; 4.1 GMP Minicircle Manufacturing; 4.2 Clinical Implementation; References; 4 Noncoding RNA for Cancer Gene Therapy; Abstract; 1 Introduction
000772538 5058_ $$a1.1 Mechanism and Function of Noncoding RNAs1.2 Design and Synthesis of Noncoding RNAs for Cancer Gene Therapy; 1.3 Delivery of Noncoding RNAs for Cancer Gene Therapy; 2 Conclusion; Acknowledgments; References; 5 mRNA Cancer Vaccines; Abstract; 1 mRNA Cancer Vaccines; 1.1 Introduction; 1.2 RNActive® Vaccines; 1.2.1 Induction of Antitumor Responses with RNActive® Vaccines; 1.2.2 Clinical Studies with RNActive® Vaccines; 1.2.3 Combination of RNActive® Vaccines with Chemotherapy or Radiation Therapy; 1.2.4 Clinical Study with RNActive® Vaccines in Combination with Radiotherapy
000772538 5058_ $$a1.2.5 Combination of RNActive® Vaccines with Immune Checkpoint Inhibitors1.3 Personalized mRNA Vaccines; 1.4 Cellular Vaccines: mRNA-Pulsed Dendritic Cells; 1.5 CAR T Cells; 2 Conclusion; Acknowledgments; References; 6 Gene Therapeutic Approaches to Overcome ABCB1-Mediated Drug Resistance; Abstract; 1 Introduction; 2 Resistance Overcoming Gene Therapy Approaches; 2.1 Delivery by Transfection; 2.2 Nanoparticle-Based Delivery; 2.3 Viral Delivery; 2.4 Bacterial Delivery; 2.5 Delivery by Jet-Injection; 3 Conclusion; 7 Bacterial Toxins for Oncoleaking Suicidal Cancer Gene Therapy; Abstract.
000772538 506__ $$aAccess limited to authorized users.
000772538 588__ $$aDescription based upon print version of record.
000772538 650_0 $$aCancer$$xGene therapy.
000772538 7001_ $$aWalther, Wolfgang.
000772538 77608 $$iPrint version:$$aWalther, Wolfgang$$tCurrent Strategies in Cancer Gene Therapy$$dCham : Springer International Publishing,c2017$$z9783319429328
000772538 830_0 $$aRecent results in cancer research ;$$v209.
000772538 852__ $$bebk
000772538 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-42934-2$$zOnline Access$$91397441.1
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