Section A: Bipolar Depression: Clinical Phenotype & Course of Illness
1) History of Bipolar Disorder and its Treatment
2) Clinical Diagnosis of Bipolar Depression (including differential diagnosis of UP and BP depression)
3) Course and Outcome of Bipolar Disorder (focusing on depressive aspects)
4) Suicide and Bipolar Disorder
Section B: Bipolar Depression: Neurobiology
5) Genetics of Bipolar Disorder
6) Molecular and Cellular Neurobiology of Bipolar Depression
7) Non-Pharmacological Treatments and Chronobiological Aspects of Bipolar Depression: Implications for Novel Therapeutics
8) Neuroimaging of Bipolar Depression: Therapeutic Implications
Section C: Acute and Long-term Treatment of Bipolar Depression
9) Pharmacological Treatment of the Acute and Continuation Phases of Bipolar Depression
10) Pharmacological Treatment of the Maintenance Phase of Bipolar Depression
11) Non-pharmacotherapeutic Somatic Treatments for Bipolar Depression (ECT, DBS, rTMS)
12) Potential Novel Therapeutics for Bipolar Depression
Section D: Treatment of Bipolar Disorder in Special Populations
13) Late Onset Bipolar Disorder
14) Childhood Onset Bipolar Disorder
15) The use of Psychotropic Medications in Bipolar Disorder during Pregnancy
16) Concluding Remarks.