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Foreword; Preface; Contents; Contributors; Chapter 1: Cardio-cerebrovascular Comorbidity; 1.1 Epidemiological Evidence; 1.1.1 Migraine andßIschemic Stroke; 1.1.2 Migraine andßHemorrhagic Stroke; 1.1.3 Migraine andßCardiac Vascular Diseases; 1.1.4 Migraine andßVascular Abnormalities atßBrain Neuroimaging; 1.2 Monogenic Diseases withßMigraine andßStroke; 1.3 Mechanisms Linking Migraine toßCardiovascular Diseases; 1.4 Implications forßClinicians; 1.5 Gaps andßFuture Research; References; Chapter 2: Psychiatric Comorbidity inßMigraine andßChronic Headache; 2.1 Introduction.
2.2 Psychiatric Comorbidities Associated withßMigraine: Major Depression2.3 Bipolar Disorders andßMigraine; 2.4 Anxiety Disorders andßMigraine; 2.5 Impulsivity, Aggression, andßMigraine; 2.6 Stress andßMigraine; 2.7 Stress, Post-traumatic Stress Disorder, andßMigraine; 2.8 Sleeping Disorders andßMigraine; 2.9 Substance Abuse andßMigraine; 2.10 Suicidality andßMigraine; 2.11 The Importance ofßScreening Instruments inßtheßDetection ofßPsychiatric Comorbidity; 2.12 Discussion; 2.13 Conclusive Remarks andßFuture Perspectives; References; Chapter 3: Epilepsy Comorbidity; 3.1 Introduction.
3.2 Prevalence ofßEpilepsy inßPeople withßMigraine3.3 Prevalence ofßHeadache inßEpileptic Patients; 3.3.1 Temporal Relationship ofßHeadache withßSeizures; 3.4 Classification Concerns andßSome Definition Proposals; 3.5 Mechanisms Underlying Epilepsy andßMigraine Comorbidity; 3.6 Genetic Aspects ofßtheßMigraine-Epilepsy Comorbidity; 3.7 Therapeutic Implications; 3.8 Clinical andßInstrumental Assessment; 3.9 Conclusions; References; Chapter 4: Visceral Pain Comorbidity inßHeadache; 4.1 Introduction; 4.2 Visceral Pain: Clinical Features andßPathophysiology; 4.3 Cardiovascular Pain andßHeadache.
4.4 Gastrointestinal Pain andßHeadache4.4.1 Headache Conditions Associated withßGastrointestinal Pain Symptoms; 4.4.2 Functional Gastrointestinal Diseases andßHeadache; 4.5 Urinary Pain andßHeadache; 4.5.1 Interstitial Cystitis/Painful Bladder Syndrome andßMigraine; 4.6 Pain fromßtheßReproductive Organs andßHeadache; 4.7 Visceral Pain andßHeadache: More ThanßaßSimple Co-occurrence; 4.8 Conclusions; References; Chapter 5: Fibromyalgia; 5.1 Introduction; 5.2 Diagnosis ofßFibromyalgia; 5.3 Prevalence ofßFibromyalgia inßPrimary Headache.
5.4 Clinical Features ofßHeadache Patients withßFM Comorbidity5.5 Pathophysiology ofßFibromyalgia Comorbidity; 5.6 Possible Therapeutic Approach toßMigraine and Tension-ƯType Headache Patients withßFM Comorbidity; 5.7 Final Remarks; References; Chapter 6: Sleep Disorders Comorbidity; 6.1 Introduction; 6.2 Pathophysiological Aspects; 6.2.1 Common Anatomical Pathways; 6.2.2 Shared Neurotransmitters; 6.2.3 Genetic Mechanism; 6.2.4 Chronobiological Mechanisms; 6.2.5 Induced by Common Behavioral Dysfunctions; 6.2.6 Early Life Dysfunctions; 6.2.7 Sleep asßaßHeadache Trigger; 6.2.8 Bidirectional Impact.
2.2 Psychiatric Comorbidities Associated withßMigraine: Major Depression2.3 Bipolar Disorders andßMigraine; 2.4 Anxiety Disorders andßMigraine; 2.5 Impulsivity, Aggression, andßMigraine; 2.6 Stress andßMigraine; 2.7 Stress, Post-traumatic Stress Disorder, andßMigraine; 2.8 Sleeping Disorders andßMigraine; 2.9 Substance Abuse andßMigraine; 2.10 Suicidality andßMigraine; 2.11 The Importance ofßScreening Instruments inßtheßDetection ofßPsychiatric Comorbidity; 2.12 Discussion; 2.13 Conclusive Remarks andßFuture Perspectives; References; Chapter 3: Epilepsy Comorbidity; 3.1 Introduction.
3.2 Prevalence ofßEpilepsy inßPeople withßMigraine3.3 Prevalence ofßHeadache inßEpileptic Patients; 3.3.1 Temporal Relationship ofßHeadache withßSeizures; 3.4 Classification Concerns andßSome Definition Proposals; 3.5 Mechanisms Underlying Epilepsy andßMigraine Comorbidity; 3.6 Genetic Aspects ofßtheßMigraine-Epilepsy Comorbidity; 3.7 Therapeutic Implications; 3.8 Clinical andßInstrumental Assessment; 3.9 Conclusions; References; Chapter 4: Visceral Pain Comorbidity inßHeadache; 4.1 Introduction; 4.2 Visceral Pain: Clinical Features andßPathophysiology; 4.3 Cardiovascular Pain andßHeadache.
4.4 Gastrointestinal Pain andßHeadache4.4.1 Headache Conditions Associated withßGastrointestinal Pain Symptoms; 4.4.2 Functional Gastrointestinal Diseases andßHeadache; 4.5 Urinary Pain andßHeadache; 4.5.1 Interstitial Cystitis/Painful Bladder Syndrome andßMigraine; 4.6 Pain fromßtheßReproductive Organs andßHeadache; 4.7 Visceral Pain andßHeadache: More ThanßaßSimple Co-occurrence; 4.8 Conclusions; References; Chapter 5: Fibromyalgia; 5.1 Introduction; 5.2 Diagnosis ofßFibromyalgia; 5.3 Prevalence ofßFibromyalgia inßPrimary Headache.
5.4 Clinical Features ofßHeadache Patients withßFM Comorbidity5.5 Pathophysiology ofßFibromyalgia Comorbidity; 5.6 Possible Therapeutic Approach toßMigraine and Tension-ƯType Headache Patients withßFM Comorbidity; 5.7 Final Remarks; References; Chapter 6: Sleep Disorders Comorbidity; 6.1 Introduction; 6.2 Pathophysiological Aspects; 6.2.1 Common Anatomical Pathways; 6.2.2 Shared Neurotransmitters; 6.2.3 Genetic Mechanism; 6.2.4 Chronobiological Mechanisms; 6.2.5 Induced by Common Behavioral Dysfunctions; 6.2.6 Early Life Dysfunctions; 6.2.7 Sleep asßaßHeadache Trigger; 6.2.8 Bidirectional Impact.