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000777751 019__ $$a962065143$$a974649591$$a981095211
000777751 020__ $$a9783319433653$$q(electronic book)
000777751 020__ $$a3319433652$$q(electronic book)
000777751 020__ $$z9783319433639
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000777751 0247_ $$a10.1007/978-3-319-43365-3$$2doi
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000777751 24504 $$aThe Ageing Immune System and Health$$cedited by Valquiria Bueno, Janet M. Lord, Thomas A. Jackson.
000777751 264_1 $$aCham :$$bSpringer,$$c©2017.
000777751 300__ $$a1 online resource (xii, 182 pages) :$$billustrations.
000777751 336__ $$atext$$btxt$$2rdacontent
000777751 337__ $$acomputer$$bc$$2rdamedia
000777751 338__ $$aonline resource$$bcr$$2rdacarrier
000777751 347__ $$atext file$$bPDF$$2rda
000777751 5050_ $$a1. Introduction -- 2. Innate Immune Response and Ageing (neutrophils, monocytes, dendritic cells, DAMPs, PAMPs -- 3. Adaptive Immune Response and Aging (T and B lymphocytes, naïve, effector and memory phenotypes and functions) -- 4. Modulatory/Suppressive Cells and Ageing (T regulatory cells, B regulatory cells, Myeloid Derived Suppressor Cells, Modulatory Neutrophils, M1 and M2 macrophages) -- 5. Mucosal Immune System and Ageing -- 6. Epigenetics and Ageing -- 7. Cancer and Ageing -- 8. Infections/Vaccination and Ageing -- 9. Cytomegalovirus and immmunosenescence -- 10. Frailty and Ageing -- 11. Inflammation and Neurodegenerative Diseases and Ageing -- 12. Effects of chronic inflammatory diseases (chronic kidney disease, rheumatoid arthritis, crohns disease etc) on the ageing of the immune system -- 13. Interventions in Elderly focusing Immunosenescence (physical activity, nutrition, supplements).
000777751 506__ $$aAccess limited to authorized users.
000777751 520__ $$aThe present book intends to provide an update on immunosenescence and how deficiencies in the immune system contribute to a higher susceptibility to infections, decline in organ function, reduced vaccination responses, age-related disease and the ageing process itself, negatively affecting longevity. Our focus is on the main changes in immune system cells and their products occurring during the ageing process and the possible consequences for health and disease. This includes: discussion of the modulatory and/or suppressive mechanisms associated with the alterations in T regulatory cells, B regulatory cells and Myeloid Derived Suppressor cells; changes in the immune system observed in chronic neurodegenerative diseases, cancer, lung disease and frailty will also be discussed. Most importantly we provide recent literature information about possible interventions (focusing on physical activity) that could alleviate the negative effects of immunosenescence. The Ageing Immune System and Health is a comprehensive guide on the field intended to all physicians, researchers, professors and students interested on relationship between immune system, ageing and health.
000777751 588__ $$aDescription based on print  version record.
000777751 650_0 $$aMedicine.
000777751 650_0 $$aImmunology.
000777751 650_0 $$aGeriatrics.
000777751 650_0 $$aCytology.
000777751 650_0 $$aAging.
000777751 7001_ $$aBueno, Valquiria,$$eeditor.
000777751 7001_ $$aLord, Janet M.,$$eeditor.
000777751 7001_ $$aJackson, Thomas A.,$$eeditor.
000777751 77608 $$iPrint version:$$tAgeing Immune System and Health.$$dCham : Springer, ©2017$$z9783319433639
000777751 852__ $$bebk
000777751 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-43365-3$$zOnline Access$$91397441.1
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000777751 980__ $$aEBOOK
000777751 980__ $$aBIB
000777751 982__ $$aEbook
000777751 983__ $$aOnline
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