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Foreword; Series Editors' Preface; About the Indian Institute of Metals; Genesis and History of the Series; Current Series Information; About This Book; Preface; Contents; Dr. Bikramjit Basu; Dr. Sourabh Ghosh; Abstracts and Keywords; 1 Introduction; 1.1 Clinical Perspective; 1.2 Failure of Implants; 1.3 Defining Biomaterials and Related Concepts; 1.4 Conclusion; References; 2 Case Study: Hydroxyapatite-Titanium Bulk Composites for Bone Tissue Engineering Applications; 2.1 Background: Brittleness of Hydroxyapatite; 2.2 Processing of HA-Ti Composites; 2.2.1 Conventional Sintering
2.2.2 Advanced Sintering2.3 Mechanical Properties; 2.4 Toughening Mechanisms and Toughness Properties; 2.5 Correlation with Existing Theoretical Models; 2.6 Biocompatibility Properties of HA-Ti Composites; 2.6.1 in vivo Biocompatibility; 2.7 Future Perspective; References; 3 Case Study: Hydroxyapatite Based Microporous/Macroporous Scaffolds; 3.1 Relevance of Porous Scaffolds; 3.2 HA-Based Microporous Scaffolds; 3.2.1 Osteoblast-like Cell Adhesion and Spreading; 3.2.2 Osteoblast-like Cell Growth and Differentiation; 3.3 Polymer-Replication Based Processing of HA-Based Macroporous Scaffold
3.4 HA-Gelatin Based Micro Porous Scaffold3.4.1 Freeze Drying-Cryogenic Curing Based Processing Approach; 3.4.2 Micro-CT Analysis of Porous Architecture; 3.4.3 BSA Adsorption/Release; 3.5 Challenges in Bone-Mimicking Porous Scaffolds; 3.6 Closure; References; 4 Case Study: Osseointegration of Strontium Containing Glass Ceramic; 4.1 Introduction; 4.2 Materials and Methods; 4.2.1 Materials; 4.2.2 in vivo Implantation; 4.2.3 Explantation and Histopathological Analysis; 4.2.4 Bone Labeling; 4.2.5 Micro-CT Analysis; 4.2.6 Statistical Analysis; 4.2.7 Bone Morphometric Analysis
4.3 in vivo Osseointegration4.3.1 Histological Observations; 4.3.2 Bone Labeling; 4.4 Discussion; 4.5 Closure; References; 5 Microstructure and Composition Dependent Physical and Cytocompatibility Property of Glass-Ceramics for Dental Restoration; 5.1 Background-Materials for Dental Restorations; 5.2 Microstructure-Mechanical Property Correlation; 5.3 Biomineralisation in Artificial Saliva; 5.4 Wear Resistance in Artificial Saliva; 5.5 Cell Proliferation and Differentiation, in vitro; 5.6 Bactericidal Property, in vitro; 5.7 Correlation Among Microstructure, Property and Cytocompatibility
5.8 SummaryReferences; 6 Processing, Tensile and Fracture Properties of Injection Molded HDPE-Al2O3-HAp Hybrid Composites; 6.1 Introduction; 6.2 Injection Moulding; 6.3 HDPE Composites with 30 % Ceramic Fillers; 6.3.1 Processing Related Challenges; 6.3.2 Compositional Dependence of Viscoelastic Properties; 6.3.3 Notched Behavior in Flexure; 6.4 HDPE Composites with 40 % Ceramic Fillers; 6.4.1 Tensile Properties; 6.4.2 Cell Adhesion and Proliferation; 6.4.3 in vitro Mineralization; 6.4.4 Protein Adsorption and Cell Functionality; 6.4.5 Influence of Surface Energy on in vitro Mineralization
2.2.2 Advanced Sintering2.3 Mechanical Properties; 2.4 Toughening Mechanisms and Toughness Properties; 2.5 Correlation with Existing Theoretical Models; 2.6 Biocompatibility Properties of HA-Ti Composites; 2.6.1 in vivo Biocompatibility; 2.7 Future Perspective; References; 3 Case Study: Hydroxyapatite Based Microporous/Macroporous Scaffolds; 3.1 Relevance of Porous Scaffolds; 3.2 HA-Based Microporous Scaffolds; 3.2.1 Osteoblast-like Cell Adhesion and Spreading; 3.2.2 Osteoblast-like Cell Growth and Differentiation; 3.3 Polymer-Replication Based Processing of HA-Based Macroporous Scaffold
3.4 HA-Gelatin Based Micro Porous Scaffold3.4.1 Freeze Drying-Cryogenic Curing Based Processing Approach; 3.4.2 Micro-CT Analysis of Porous Architecture; 3.4.3 BSA Adsorption/Release; 3.5 Challenges in Bone-Mimicking Porous Scaffolds; 3.6 Closure; References; 4 Case Study: Osseointegration of Strontium Containing Glass Ceramic; 4.1 Introduction; 4.2 Materials and Methods; 4.2.1 Materials; 4.2.2 in vivo Implantation; 4.2.3 Explantation and Histopathological Analysis; 4.2.4 Bone Labeling; 4.2.5 Micro-CT Analysis; 4.2.6 Statistical Analysis; 4.2.7 Bone Morphometric Analysis
4.3 in vivo Osseointegration4.3.1 Histological Observations; 4.3.2 Bone Labeling; 4.4 Discussion; 4.5 Closure; References; 5 Microstructure and Composition Dependent Physical and Cytocompatibility Property of Glass-Ceramics for Dental Restoration; 5.1 Background-Materials for Dental Restorations; 5.2 Microstructure-Mechanical Property Correlation; 5.3 Biomineralisation in Artificial Saliva; 5.4 Wear Resistance in Artificial Saliva; 5.5 Cell Proliferation and Differentiation, in vitro; 5.6 Bactericidal Property, in vitro; 5.7 Correlation Among Microstructure, Property and Cytocompatibility
5.8 SummaryReferences; 6 Processing, Tensile and Fracture Properties of Injection Molded HDPE-Al2O3-HAp Hybrid Composites; 6.1 Introduction; 6.2 Injection Moulding; 6.3 HDPE Composites with 30 % Ceramic Fillers; 6.3.1 Processing Related Challenges; 6.3.2 Compositional Dependence of Viscoelastic Properties; 6.3.3 Notched Behavior in Flexure; 6.4 HDPE Composites with 40 % Ceramic Fillers; 6.4.1 Tensile Properties; 6.4.2 Cell Adhesion and Proliferation; 6.4.3 in vitro Mineralization; 6.4.4 Protein Adsorption and Cell Functionality; 6.4.5 Influence of Surface Energy on in vitro Mineralization