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Preface; Contents; Electrochemical Glucose Biosensors for Diabetes Care; 1 Introduction; 2 General Aspects of Glucose Measurement; 2.1 Requirements for Development, Manufacture, and Sale of Glucose Sensors for Diabetes Management; 2.2 Glucose Measurement Systems for Different Use Cases; 2.3 Glucose Measurement Technology; 3 Self-Monitoring of Blood Glucose (SMBG); 3.1 Requirements; 3.1.1 Personal User Requirements; 3.1.2 Healthcare Provider Requirements; 3.1.3 Payer Requirements; 3.2 Monitoring Systems; 3.2.1 Measurement Principles; Active Components; Measurement Methods.
3.2.2 Sensor Manufacturing3.3 Performance of Systems Used for SMBG; 3.3.1 Reference Methodology; 3.3.2 Regulatory Guidance; 3.3.3 Performance Assessment; Consensus Error Grid and Estimation of Clinical Impact; Surveillance Error Grid; Other Means of Visualizing SMBG Performance Data; Beyond the Regression Line; 3.3.4 System Performance of SMBG and POC Systems; 3.3.5 Calls for Improved Performance and Postlaunch Monitoring; 3.4 SMBG Outlook; 4 Continuous Glucose Monitoring (CGM); 4.1 Requirements; 4.1.1 Personal User Requirements; 4.1.2 Healthcare Provider Requirements.
4.1.3 Payer Requirements4.1.4 Regulatory Requirements; 4.2 Monitoring Systems; 4.2.1 Sample Matrix; 4.2.2 Sensor Technology; Sensor Layout; Enzyme Electrode; Diffusional Barrier Membrane; Biocompatible Coating; Sensor Technology Used in Commercialized Systems; 4.2.3 Sensor Manufacturing; 4.2.4 Data; Data Processing; Data Transfer; Data Display; 4.3 Performance of CGM Systems; 4.3.1 Performance Assessment; 4.3.2 Performance of Commercially Available CGM Systems; 4.4 CGM System Outlook; 5 Conclusion; References; Electrochemical Arrays for Bioassay Applications; 1 Introduction.
2 Specialized Reviews of Principles and Practices3 Unmodified Electrochemical Array Elements; 4 Electrode Arrays Modified with Enzymes; 5 Array Elements Modified with Antibodies or Antigens; 6 Electrochemical Nucleic Acid Arrays; 7 Electrode Arrays Modified with Cells or Tissues; 8 Other Modifications of Electrochemical Array Elements; 9 Conclusions and Future Directions; References; Bioelectronic Tongues Employing Electrochemical Biosensors; 1 Introduction; 1.1 Types of Biosensors Used in the Array; 1.1.1 Potentiometric Biosensors; 1.1.2 Voltammetric Biosensors; 1.1.3 Other Sensors.
1.2 Chemometric Tools1.3 Type of Applications; 2 Systems Using a Single Biosensor; 3 Biosensor Arrays Incorporating One Enzyme; 3.1 Potentiometric Systems; 3.2 Voltammetric Systems; 4 Biosensor Arrays Employing Several Enzymes; 4.1 Determining One Substrate; 4.2 Coupling Different Enzymes in the Same Sensing Device; 4.3 Determining Several Substrates; 5 Inhibition Electronic Tongues; 5.1 Determination of Pesticides; 5.2 Other Inhibition Systems; 6 Concluding Remarks; References; Novel Electrochemical DNA Biosensors as Tools for Investigation and Detection of DNA Damage; 1 Introduction.
3.2.2 Sensor Manufacturing3.3 Performance of Systems Used for SMBG; 3.3.1 Reference Methodology; 3.3.2 Regulatory Guidance; 3.3.3 Performance Assessment; Consensus Error Grid and Estimation of Clinical Impact; Surveillance Error Grid; Other Means of Visualizing SMBG Performance Data; Beyond the Regression Line; 3.3.4 System Performance of SMBG and POC Systems; 3.3.5 Calls for Improved Performance and Postlaunch Monitoring; 3.4 SMBG Outlook; 4 Continuous Glucose Monitoring (CGM); 4.1 Requirements; 4.1.1 Personal User Requirements; 4.1.2 Healthcare Provider Requirements.
4.1.3 Payer Requirements4.1.4 Regulatory Requirements; 4.2 Monitoring Systems; 4.2.1 Sample Matrix; 4.2.2 Sensor Technology; Sensor Layout; Enzyme Electrode; Diffusional Barrier Membrane; Biocompatible Coating; Sensor Technology Used in Commercialized Systems; 4.2.3 Sensor Manufacturing; 4.2.4 Data; Data Processing; Data Transfer; Data Display; 4.3 Performance of CGM Systems; 4.3.1 Performance Assessment; 4.3.2 Performance of Commercially Available CGM Systems; 4.4 CGM System Outlook; 5 Conclusion; References; Electrochemical Arrays for Bioassay Applications; 1 Introduction.
2 Specialized Reviews of Principles and Practices3 Unmodified Electrochemical Array Elements; 4 Electrode Arrays Modified with Enzymes; 5 Array Elements Modified with Antibodies or Antigens; 6 Electrochemical Nucleic Acid Arrays; 7 Electrode Arrays Modified with Cells or Tissues; 8 Other Modifications of Electrochemical Array Elements; 9 Conclusions and Future Directions; References; Bioelectronic Tongues Employing Electrochemical Biosensors; 1 Introduction; 1.1 Types of Biosensors Used in the Array; 1.1.1 Potentiometric Biosensors; 1.1.2 Voltammetric Biosensors; 1.1.3 Other Sensors.
1.2 Chemometric Tools1.3 Type of Applications; 2 Systems Using a Single Biosensor; 3 Biosensor Arrays Incorporating One Enzyme; 3.1 Potentiometric Systems; 3.2 Voltammetric Systems; 4 Biosensor Arrays Employing Several Enzymes; 4.1 Determining One Substrate; 4.2 Coupling Different Enzymes in the Same Sensing Device; 4.3 Determining Several Substrates; 5 Inhibition Electronic Tongues; 5.1 Determination of Pesticides; 5.2 Other Inhibition Systems; 6 Concluding Remarks; References; Novel Electrochemical DNA Biosensors as Tools for Investigation and Detection of DNA Damage; 1 Introduction.