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Introduction; Contents; Contributors; 1: Dealing withßtheßGross Specimen; Introduction; Core Biopsies; Dealing withßSpecimens fromßConservative Surgery; Reporting Excision Margin Status; Lumpectomy Specimens; Mastectomy Specimens; Axillary Lymph Node Specimens andßSpecimens Received AfterßNeoadjuvant Therapy; References; 2: Handling Neoadjuvant Therapy Specimens; Introduction; Pretreatment Diagnosis; Specimen Handling; Wide Local Excision Specimens; Mastectomies; Axillary Lymph Nodes; Histological Reporting; Breast; Axillary Lymph Nodes; Definition ofßpCR.
Grading ofßResponse Retesting ofßTumor Markers Post-Ưneoadjuvant Therapy; Neoadjuvant Therapy andßClinical Trials; References; 3: Proliferative Breast Lesions; Introduction; Ductal Lesions; Usual Epithelial Hyperplasia; Atypical Ductal Hyperplasia; Ductal Carcinoma InßSitu; Epithelial Proliferation (Hyperplasia, Atypia, andßDCIS) WithinßPapillary Lesions; Paget's Disease ofßtheßNipple; Lobular Lesions; Atypical Lobular Hyperplasia andßClassical Lobular Carcinoma InßSitu (In Situ Lobular Neoplasia); Columnar Cell Lesions; Columnar Cell Change andßColumnar Cell Hyperplasia.
Flat Epithelial AtypiaReferences; 4: Problematic Core Biopsies; Introduction; Macroscopic Specimen Handling; Calcification Problems; Reporting Categories; B1, Normal Tissue; B2, Benign; B5, Malignant; Category B5a: InßSitu Carcinoma; Category B5b: Invasive; Assessment ofßPrognostic andßPredictive Factors inßInvasive Carcinoma inßCore Biopsy; Problematic Malignant Lesions; B3, Lesion ofßUncertain Malignant Potential; Atypical Intraductal Epithelial Proliferations (AIDEPs); Lobular Neoplasia; Flat Epithelial Atypia; Apocrine Lesions; Papillary Lesions.
Radial Scar/Complex Sclerosing Lesion (CSL) Phyllodes Tumor; Spindle Cell Lesions; Mucocele-Like Lesions; Other Rare Lesions; B4, Suspicious; References; 5: Ductal Carcinoma InßSitu; Introduction; Specimen Handling; Diagnostic Core Biopsies; Diagnostic andßTherapeutic Excision Specimens; Re-excision Specimens; Therapeutic Mammoplasties; Mastectomy Specimens; Disease Extent inßExcision Specimens; Diagnostic Approaches withßCore Biopsies andßExcisions; Reporting Diagnostic Core Biopsies (Small andßLarge Volume); Reporting Therapeutic Large Core (Vacuum-Assisted) Biopsies.
Reporting Excision Biopsies Grading DCIS; Low-Grade DCIS; Intermediate-Grade DCIS; High-Grade DCIS; Problems inßGrading DCIS; Architectural Patterns andß"Special" Types ofßDCIS; Micropapillary DCIS; Apocrine DCIS; DCIS Arising inßtheßContext ofßaßColumnar Cell Lesion withßAtypia; Rare Forms ofßDCIS; DCIS FollowingßNeoadjuvant Systemic Therapy; Microinvasion andßInvasion inßDCIS; The Use ofßImmunohistochemistry inßDCIS; Differentiating Low/Intermediate-ƯGrade DCIS fromßBenign Proliferations; Distinguishing Complex Sclerosing Processes fromßInvasive Disease.
Grading ofßResponse Retesting ofßTumor Markers Post-Ưneoadjuvant Therapy; Neoadjuvant Therapy andßClinical Trials; References; 3: Proliferative Breast Lesions; Introduction; Ductal Lesions; Usual Epithelial Hyperplasia; Atypical Ductal Hyperplasia; Ductal Carcinoma InßSitu; Epithelial Proliferation (Hyperplasia, Atypia, andßDCIS) WithinßPapillary Lesions; Paget's Disease ofßtheßNipple; Lobular Lesions; Atypical Lobular Hyperplasia andßClassical Lobular Carcinoma InßSitu (In Situ Lobular Neoplasia); Columnar Cell Lesions; Columnar Cell Change andßColumnar Cell Hyperplasia.
Flat Epithelial AtypiaReferences; 4: Problematic Core Biopsies; Introduction; Macroscopic Specimen Handling; Calcification Problems; Reporting Categories; B1, Normal Tissue; B2, Benign; B5, Malignant; Category B5a: InßSitu Carcinoma; Category B5b: Invasive; Assessment ofßPrognostic andßPredictive Factors inßInvasive Carcinoma inßCore Biopsy; Problematic Malignant Lesions; B3, Lesion ofßUncertain Malignant Potential; Atypical Intraductal Epithelial Proliferations (AIDEPs); Lobular Neoplasia; Flat Epithelial Atypia; Apocrine Lesions; Papillary Lesions.
Radial Scar/Complex Sclerosing Lesion (CSL) Phyllodes Tumor; Spindle Cell Lesions; Mucocele-Like Lesions; Other Rare Lesions; B4, Suspicious; References; 5: Ductal Carcinoma InßSitu; Introduction; Specimen Handling; Diagnostic Core Biopsies; Diagnostic andßTherapeutic Excision Specimens; Re-excision Specimens; Therapeutic Mammoplasties; Mastectomy Specimens; Disease Extent inßExcision Specimens; Diagnostic Approaches withßCore Biopsies andßExcisions; Reporting Diagnostic Core Biopsies (Small andßLarge Volume); Reporting Therapeutic Large Core (Vacuum-Assisted) Biopsies.
Reporting Excision Biopsies Grading DCIS; Low-Grade DCIS; Intermediate-Grade DCIS; High-Grade DCIS; Problems inßGrading DCIS; Architectural Patterns andß"Special" Types ofßDCIS; Micropapillary DCIS; Apocrine DCIS; DCIS Arising inßtheßContext ofßaßColumnar Cell Lesion withßAtypia; Rare Forms ofßDCIS; DCIS FollowingßNeoadjuvant Systemic Therapy; Microinvasion andßInvasion inßDCIS; The Use ofßImmunohistochemistry inßDCIS; Differentiating Low/Intermediate-ƯGrade DCIS fromßBenign Proliferations; Distinguishing Complex Sclerosing Processes fromßInvasive Disease.