Preface; Contents; Nanoparticles as a Technology Platform for Biomedical Imaging; 1 Origins of Nanoparticles in Biomedical Imaging; 2 The Emergence of a Synergy Between Therapeutics and Imaging; 3 An Outlook on Challenges and Future Opportunities; References; Basic Principles of In Vivo Distribution, Toxicity, and Degradation of Prospective Inorganic Nanoparticles for Imaging; 1 General Introduction; 1.1 Applying Inorganic Nanoparticles for Imaging; 1.2 Nanoparticles' Fate in a Nutshell; 1.3 The Nanoparticle-Protein Associates

1.4 Nanoparticle Coating: The Essential But Transient Element in Particle Stabilization and Follow-Up1.5 Cellular "Conditioning" of Administered Nanoparticles and Its Impact on Imaging Outcomes; 1.6 Different Aspects of Biotransformation: Therapeutic Properties, Loss of Functionality, and Potential Toxicity; 1.7 Material-Specific Degradation Patterns of Inorganic Nanoparticles In Vivo and Over Time; 2 Iron Oxide Nanoparticles; 2.1 Role, Effect, and Fate of IONP Synthetic (Polymer) and Biological (Corona) Coating

2.2 Cell Internalization of IONPs and Its Effects on Nanoparticles' Magnetic Properties2.3 Degradation and Recycling of IONPs; 2.4 In Vivo Toxicity of IONPs; 3 Quantum Dots; 3.1 Cellular Processing and Fate of QDots; 3.2 Skin: The Underemphasized Organ of Nanoparticle's Accumulation; 3.3 In Vivo Toxicity of QDs; 4 Silver Nanoparticles (Ag NPs); 4.1 Therapeutic Properties and In Vivo Behavior of Ag NPs; 4.2 Toxicity of Ag NPs; 5 Gold Nanoparticles (Au NPs); 5.1 Role, Effect, and Fate of Au NPs; 5.2 Cell Internalization of Au NPs

5.3 Long-Lasting, But Not "Eternal": The In Vivo Biopersistence of Au NPs5.4 In Vivo Toxicity of Au NPs; 6 Conclusion; References; Imaging and Therapeutic Potential of Extracellular Vesicles; 1 Introduction; 2 EV Classification and Biogenesis; 3 EV Production; 4 EV Loading; 4.1 Loading the Parent Cell Before EV Release; 4.2 Loading During EV Production; 4.3 Direct Loading or Decoration of EVs; 5 EV Isolation; 6 Characterization; 7 Engineering Vesicles for Imaging: Biodistribution Investigation; 8 Engineering Vesicles for Therapy and Theranosis; 9 Conclusions; References

Magnetic Particle Imaging1 Unmet Biomedical Imaging Needs; 2 Introduction to Magnetic Particle Imaging; 2.1 MPI Trade-Offs; 2.2 How MPI Works; 2.3 The Direct Feed-Through Challenge; 2.4 MPI Signal Is Independent of Depth; 2.5 MPI Sensitivity Is Linear, Robust, and Ideal; 2.6 MPI Resolution; 2.7 Prototype Preclinical MPI Scanners; 3 Clinical and Preclinical Applications of Magnetic Particle Imaging; 3.1 Long-Term MPI Tracking of Neural Progenitor Cells; 3.2 Dynamic, Systemic Stem Cell Tracking; 3.3 MPI Angiography Enabled by Advanced Image Reconstruction