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000778466 019__ $$a974650818$$a981112387
000778466 020__ $$a9783319421698$$qelectronic book
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000778466 020__ $$z9783319421674
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000778466 0247_ $$a10.1007/978-3-319-42169-8$$2doi
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000778466 050_4 $$aR857.N34$$bD47 2017
000778466 08204 $$a610.28$$223
000778466 24500 $$aDesign and applications of nanoparticles in biomedical imaging /$$cJeff W.M. Bulte, Michel M.J. Modo, editors.
000778466 264_1 $$aCham, Switzerland :$$bSpringer,$$c[2017]
000778466 300__ $$a1 online resource (viii, 469 pages)
000778466 336__ $$atext$$btxt$$2rdacontent
000778466 337__ $$acomputer$$2rdamedia
000778466 338__ $$aonline resource$$2rdacarrier
000778466 347__ $$atext file$$bPDF$$2rda
000778466 504__ $$aIncludes bibliographical references and index.
000778466 5050_ $$aPreface; Contents; Nanoparticles as a Technology Platform for Biomedical Imaging; 1 Origins of Nanoparticles in Biomedical Imaging; 2 The Emergence of a Synergy Between Therapeutics and Imaging; 3 An Outlook on Challenges and Future Opportunities; References; Basic Principles of In Vivo Distribution, Toxicity, and Degradation of Prospective Inorganic Nanoparticles for Imaging; 1 General Introduction; 1.1 Applying Inorganic Nanoparticles for Imaging; 1.2 Nanoparticles' Fate in a Nutshell; 1.3 The Nanoparticle-Protein Associates
000778466 5058_ $$a1.4 Nanoparticle Coating: The Essential But Transient Element in Particle Stabilization and Follow-Up1.5 Cellular "Conditioning" of Administered Nanoparticles and Its Impact on Imaging Outcomes; 1.6 Different Aspects of Biotransformation: Therapeutic Properties, Loss of Functionality, and Potential Toxicity; 1.7 Material-Specific Degradation Patterns of Inorganic Nanoparticles In Vivo and Over Time; 2 Iron Oxide Nanoparticles; 2.1 Role, Effect, and Fate of IONP Synthetic (Polymer) and Biological (Corona) Coating
000778466 5058_ $$a2.2 Cell Internalization of IONPs and Its Effects on Nanoparticles' Magnetic Properties2.3 Degradation and Recycling of IONPs; 2.4 In Vivo Toxicity of IONPs; 3 Quantum Dots; 3.1 Cellular Processing and Fate of QDots; 3.2 Skin: The Underemphasized Organ of Nanoparticle's Accumulation; 3.3 In Vivo Toxicity of QDs; 4 Silver Nanoparticles (Ag NPs); 4.1 Therapeutic Properties and In Vivo Behavior of Ag NPs; 4.2 Toxicity of Ag NPs; 5 Gold Nanoparticles (Au NPs); 5.1 Role, Effect, and Fate of Au NPs; 5.2 Cell Internalization of Au NPs
000778466 5058_ $$a5.3 Long-Lasting, But Not "Eternal": The In Vivo Biopersistence of Au NPs5.4 In Vivo Toxicity of Au NPs; 6 Conclusion; References; Imaging and Therapeutic Potential of Extracellular Vesicles; 1 Introduction; 2 EV Classification and Biogenesis; 3 EV Production; 4 EV Loading; 4.1 Loading the Parent Cell Before EV Release; 4.2 Loading During EV Production; 4.3 Direct Loading or Decoration of EVs; 5 EV Isolation; 6 Characterization; 7 Engineering Vesicles for Imaging: Biodistribution Investigation; 8 Engineering Vesicles for Therapy and Theranosis; 9 Conclusions; References
000778466 5058_ $$aMagnetic Particle Imaging1 Unmet Biomedical Imaging Needs; 2 Introduction to Magnetic Particle Imaging; 2.1 MPI Trade-Offs; 2.2 How MPI Works; 2.3 The Direct Feed-Through Challenge; 2.4 MPI Signal Is Independent of Depth; 2.5 MPI Sensitivity Is Linear, Robust, and Ideal; 2.6 MPI Resolution; 2.7 Prototype Preclinical MPI Scanners; 3 Clinical and Preclinical Applications of Magnetic Particle Imaging; 3.1 Long-Term MPI Tracking of Neural Progenitor Cells; 3.2 Dynamic, Systemic Stem Cell Tracking; 3.3 MPI Angiography Enabled by Advanced Image Reconstruction
000778466 506__ $$aAccess limited to authorized users.
000778466 520__ $$aThis book covers the most recent advances in using nanoparticles for biomedical imaging, including magnetic resonance imaging (MRI), magnetic particle imaging (MPI), nuclear medicine, ultrasound (US) imaging, computed tomography (CT), and optical imaging. Topics include nanoparticles for MRI and MPI, siRNA delivery, theranostic nanoparticles for PET imaging of drug delivery, US nanoparticles for imaging drug delivery, inorganic nanoparticles for targeted CT imaging, and quantum dots for optical imaging. This book serves as a valuable resource for the fundamental science of diagnostic nanoparticles and their interactions with biological targets, providing a practical handbook for improved detection of disease and its clinical implementation.
000778466 588__ $$aDescription based on online resource; title from digital title page (viewed on December 13, 2016).
000778466 650_0 $$aNanoparticles$$xDiagnostic use.
000778466 650_0 $$aDiagnostic imaging.
000778466 7001_ $$aBulte, Jeff W. M.,$$eeditor.
000778466 7001_ $$aModo, Michel Mathias Jeannot Joseph,$$eeditor.
000778466 77608 $$iPrint version:$$z9783319421674$$z3319421670$$w(OCoLC)951761639
000778466 852__ $$bebk
000778466 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-42169-8$$zOnline Access$$91397441.1
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000778466 982__ $$aEbook
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