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000778702 019__ $$a974649931$$a985347817
000778702 020__ $$a9783319454337$$q(electronic book)
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000778702 020__ $$z9783319454313
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000778702 0247_ $$a10.1007/978-3-319-45433-7$$2doi
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000778702 035__ $$aSP(OCoLC)967392588$$z(OCoLC)974649931$$z(OCoLC)985347817
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000778702 24504 $$aThe immune response to implanted materials and devices :$$bthe impact of the immune system on the success of an implant /$$cBruna Corradetti, editor.
000778702 264_1 $$aCham, Switzerland :$$bSpringer,$$c2017.
000778702 264_4 $$c©2017
000778702 300__ $$a1 online resource (254 pages) :$$billustrations.
000778702 336__ $$atext$$btxt$$2rdacontent
000778702 337__ $$acomputer$$bc$$2rdamedia
000778702 338__ $$aonline resource$$bcr$$2rdacarrier
000778702 347__ $$atext file$$bPDF$$2rda
000778702 500__ $$aIncludes index.
000778702 5050_ $$aHost response to implanted materials and devices -- overview -- Innate and acquired immunity: umoral and cellular components (Protein adsorption, cell recruitment, tissue response) -- Acute/Chronic inflammation, foreign body reaction -- implications -- Macrophages: from immune response to tissue restoration -- Host response to cell-grafted biomaterials -- Host response to therapeutic nanoparticles -- Host response to synthetic versus natural biomaterials (The effects of the composition, structure on function, stability, and final outcome) -- Biomimicry at the cell-material interface to mitigate the immune reaction -- Bioactive materials design for immunomodulation -- exploiting the patient's own body machinery to achieve functional tissue restoration -- Host response to materials for orthopaedic applications: current approaches and future perspectives -- Methods to activate cellular immunity or determine immune evasion.
000778702 506__ $$aAccess limited to authorized users.
000778702 520__ $$aThis book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy of an implant, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation plays in improving tolerance during cells and tissue transplant, in the treatment of orthopaedic, pancreatic, and hepatic diseases.The Immune Response to Implanted Materials and Devices is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.
000778702 650_0 $$aImplants, Artificial$$xBiocompatibility.
000778702 650_0 $$aImplants, Artificial$$xComplications.
000778702 7001_ $$aCorradetti, Bruna,$$eeditor.
000778702 77608 $$iPrint version:$$z9783319454313
000778702 852__ $$bebk
000778702 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-45433-7$$zOnline Access$$91397441.1
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000778702 980__ $$aEBOOK
000778702 980__ $$aBIB
000778702 982__ $$aEbook
000778702 983__ $$aOnline
000778702 994__ $$a92$$bISE