Incorporation of heterocycles into combinatorial chemistry / Eugene V. Babaev.
2017
QD400
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Title
Incorporation of heterocycles into combinatorial chemistry / Eugene V. Babaev.
Author
Babaev, Eugene V., author.
ISBN
9783319500157 (electronic book)
3319500155 (electronic book)
9783319500133
3319500139
3319500155 (electronic book)
9783319500133
3319500139
Published
[Cham, Switzerland] : Springer, 2017.
Copyright
©2017
Language
English
Description
1 online resource (123 pages) : illustrations.
Item Number
10.1007/978-3-319-50015-7 doi
Call Number
QD400
Dewey Decimal Classification
547.59
Summary
The author has summarized a decade of teaching combinatorial chemistry into this timely brief. The solid phase synthesis of unnatural heterocyclic alpha-amino acids is illustrated by practical examples starting from the ABCs of peptide synthesis explored in chapter one. Chapter two is concerned with the solid phase synthesis which is shown on various techniques - BillBoard, tea-bag, and Lantern devices, and demonstrated on heterocyclic examples and protocols. In the third chapter the tools for accelerating chemical synthesis - solid phase and liquid phase - are reviewed. Here the techniques of parallel refluxing (including microwave and flow technique) and parallel separation (filtration, centrifugation, evaporation, and chromatography) are described. In the chapters 4 and 5 the author goes on to describe how the liquid phase synthesis of heterocycles (reductive amination and Ugi reaction of heterocycles) is illustrated with the use of semi-automated protocols. Finally, the design of combinatorial libraries of heterocycles is reviewed including the original author's findings.
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text file PDF
Series
SpringerBriefs in molecular science.
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Print version: 9783319500133
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Table of Contents
Introduction
Peptide Synthesis of Libraries of Non-Natural Amino Acids
The choice of tools for implementing multi-stage transformations. SPOS for Beginners
Secrets of Parallel Liquid-Phase Synthesis
Most Combinatorial LPOS Reactions: Reductive Amination with a Scavenger
A Parallel Ugi Reaction
Combinatorial Heterocyclic Chemistry in Higher School.
Peptide Synthesis of Libraries of Non-Natural Amino Acids
The choice of tools for implementing multi-stage transformations. SPOS for Beginners
Secrets of Parallel Liquid-Phase Synthesis
Most Combinatorial LPOS Reactions: Reductive Amination with a Scavenger
A Parallel Ugi Reaction
Combinatorial Heterocyclic Chemistry in Higher School.