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000778768 019__ $$a974650592$$a981852696
000778768 020__ $$a9783319430638$$q(electronic book)
000778768 020__ $$a3319430637$$q(electronic book)
000778768 020__ $$z9783319430614
000778768 0247_ $$a10.1007/978-3-319-43063-8$$2doi
000778768 035__ $$aSP(OCoLC)ocn967655963
000778768 035__ $$aSP(OCoLC)967655963$$z(OCoLC)974650592$$z(OCoLC)981852696
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000778768 049__ $$aISEA
000778768 050_4 $$aRC280.D5
000778768 08204 $$a616.99/4333$$223
000778768 24500 $$aImmunotherapy for gastrointestinal cancer /$$cDavid Kerr, Rebecca Johnson, editors.
000778768 264_1 $$aCham, Switzerland :$$bSpringer,$$c2017.
000778768 300__ $$a1 online resource.
000778768 336__ $$atext$$btxt$$2rdacontent
000778768 337__ $$acomputer$$bc$$2rdamedia
000778768 338__ $$aonline resource$$bcr$$2rdacarrier
000778768 347__ $$atext file$$bPDF$$2rda
000778768 500__ $$aIncludes index.
000778768 5050_ $$aIntroduction to modern immunology -- Cell based therapy ? modified cancer cells -- Vaccines for GI cancer -- Antibody delivery of radioactive ?warheads? and cytotoxins -- Antibodies which inhibit specific cell pathways -- PD1 and PD1l immune checkpoint inhibitors -- The Role of the JAK/STAT Signaling Pathway in Immunoregulation of Gastrointestinal Cancers -- Hyper mutated colorectal cancer and neoantigen load -- Antibodies which inhibit specific cell pathways, colorectal cancer.
000778768 506__ $$aAccess limited to authorized users.
000778768 520__ $$aThis book is about the manipulation of the immune system as a therapeutic approach to gastrointestinal cancer and its clinical applications, exploring therapeutic approaches which might be taken under the broad banner of immunotherapy. Starting by introducing concepts of modern immunology, the clinical applications of immunotherapy are then discussed. The reader will learn about the three broad classes of immune therapeutic agents: cell-based treatment; antibody therapy; cytokine application and the key effector cells and mechanisms which might cause tumour rejection. The reverse side of this equation, the genetic and molecular mechanisms which the tumour can use to escape immune control and regulation, is also discussed. Through reviewing the most up-to-date evidence, this volume provides an overview of the important scientific lessons learned from past failure of immunotherapeutics in the clinic and highlights more positive recent data, coupled to practical guidelines for clinical usage. Written by a team of worldwide experts, this is an indispensable guide for medical oncologists, surgical oncologists, radiation therapists, pharmacists, oncology nurse specialists. .
000778768 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed January 18, 2017).
000778768 650_0 $$aGastrointestinal system$$xCancer$$xImmunotherapy.
000778768 7001_ $$aKerr, David,$$eeditor.
000778768 7001_ $$aJohnson, Rebecca,$$eeditor
000778768 77608 $$iPrint version:$$z9783319430614
000778768 852__ $$bebk
000778768 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-43063-8$$zOnline Access$$91397441.1
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000778768 980__ $$aEBOOK
000778768 980__ $$aBIB
000778768 982__ $$aEbook
000778768 983__ $$aOnline
000778768 994__ $$a92$$bISE