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000778862 019__ $$a974651698$$a981112637
000778862 020__ $$a9783319426327$$q(electronic book)
000778862 020__ $$a331942632X$$q(electronic book)
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000778862 0247_ $$a10.1007/978-3-319-42632-7$$2doi
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000778862 08204 $$a616.99433$$223
000778862 24500 $$aGastrointestinal stromal tumors :$$bbench to bedside /$$cCharles R. Scoggins, Chandrajit P. Raut, John T. Mullen, editors.
000778862 264_1 $$aCham, Switzerland :$$bSpringer,$$c2017.
000778862 264_4 $$c©2017
000778862 300__ $$a1 online resource (242 pages) :$$billustrations.
000778862 336__ $$atext$$btxt$$2rdacontent
000778862 337__ $$acomputer$$bc$$2rdamedia
000778862 338__ $$aonline resource$$bcr$$2rdacarrier
000778862 347__ $$atext file$$bPDF$$2rda
000778862 5050_ $$aEtiology/Epidemiology -- Pathology -- Molecular Genetics of GIST -- Pediatric GIST/Inheritable Disease -- Natural History -- Radiographic Imaging -- Endoscopic Evaluation -- Prognostic Factors for Localized Disease -- Management of Localized GIST: Non-Surgical Approaches-Surveillance and Endoscopic Resection -- Surgery for Localized GIST -- Minimally Invasive Surgery for GIST -- Neoadjuvant Rx and Surgical Consolidation -- Imatinib -- Management of Locally Advanced GIST -- Prognostic Factors for Advanced GIST -- Concepts of Targeted Therapy Management, Dose Escalation, Tailoring Therapy Based on Specific Mutations, Second Line Therapy -- Surgical Debulking of Metastatic GIST -- Liver Resection/Ablation of Metastatic GIST -- Palliative Care.
000778862 506__ $$aAccess limited to authorized users.
000778862 520__ $$aThis textbook provides a comprehensive, state of the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in GIST. The book reviews new data about risk factors for the disease, profiles the new staging system for GIST, highlights our current understanding of genetic mutations that lead to GIST, and provides new perspectives about imaging of GIST tumors. For localized disease, a greater appreciation of organ-sparing approaches and the importance of preservation of gastrointestinal function is discussed in detail, and advances in surgical techniques are highlighted, including minimally invasive surgery. For metastatic disease, the molecular biology of GIST is reviewed in a detailed and understandable manner, including the data that has fostered novel targeted approaches that have revolutionized management. Several landmark trials have been published in the last few years and are placed in context with respect to current management. Integration of surgery and systemic therapy through consolidative approaches has yielded provocative data that promises to further advance the field, and major advances in this domain are also discussed. Gastrointestinal Stromal Tumors: Bench to Bedside will serve as a very useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information.
000778862 650_0 $$aGastrointestinal stromal tumors.
000778862 7001_ $$aScoggins, Charles R.,$$eeditor.
000778862 7001_ $$aRaut, Chandrajit P.,$$eeditor.
000778862 7001_ $$aMullen, John T.,$$eeditor.
000778862 77608 $$iPrint version:$$z9783319426303
000778862 852__ $$bebk
000778862 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-42632-7$$zOnline Access$$91397441.1
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000778862 982__ $$aEbook
000778862 983__ $$aOnline
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