The CAPRISA clinical trials : HIV treatment and prevention / Quarraisha Abdool Karim, Salim S. Abdool Karim, Cheryl Baxter, editors.
Abdool Karim, Q. (Quarraisha), editor.; Karim, Salim S. Abdool, editor.; Baxter, Cheryl, editor.
2017
RC606.6
Available Online

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Title
The CAPRISA clinical trials : HIV treatment and prevention / Quarraisha Abdool Karim, Salim S. Abdool Karim, Cheryl Baxter, editors.
ISBN
9783319475189 (electronic book)
3319475185 (electronic book)
9783319475172
DOI
https://doi.org/10.1007/978-3-319-47518-9
Published
Cham, Switzerland : Springer, 2017.
Language
English
Description
1 online resource.
Item Number
10.1007/978-3-319-47518-9 doi
Call Number
RC606.6
Dewey Decimal Classification
616.97/9206
Summary
Since its inception 14 years ago, CAPRISA has conducted numerous clinical studies that have influenced international TB-HIV treatment guidelines as well as HIV prevention through innovations in the microbicide and vaccine fields. This book provides a historical account of how each of CAPRISA?s high impact studies was created, developed, implemented, analysed and communicated. In doing so, the reader is taken on a journey that provides glimpses into the genesis of research ideas and how this ultimately leads to a range of HIV prevention and treatment studies that have impacted the global response to the HIV and TB epidemics. Comprised of 5 sections, the book details the following: HIV epidemic in South Africa and the establishment of a research centre to undertake clinical, epidemiological and laboratory research on HIV. CAPRISA?s clinical trials on HIV and HSV-2 prevention. These studies investigated the impact of tenofovir gel as topical antiretroviral pre-exposure prophylaxis (PrEP), implementation of topical PrEP through family planning clinics, conditional cash incentives for HIV prevention, HIV vaccines, and passive immunisation with broadly neutralising antibodies. CAPRISA?s research on the treatment of HIV and TB co-infection. A review of the major scientific findings from the CAPRISA studies on acute infection and genital mucosal immunology. Essential support activities for the conduct of clinical trials, including research laboratories and pharmacies, as well as establishing effective communication and sustainable structures for community engagement to maintain effective and respectful partnerships with participating communities. The book concludes with a chapter about the challenges facing future HIV prevention and treatment trials. The CAPRISA Clinical Trials: HIV Treatment and Prevention is a resource for undergraduate and postgraduate students, health care providers, doctors, decision-makers and researchers who are seeking guidance and insights on clinical trials ? their creation, conduct and impact.
Note
Includes index.
Access Note
Access limited to authorized users.
Digital File Characteristics
text file PDF
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed January 30, 2017).
Added Author
Abdool Karim, Q. (Quarraisha), editor.
Karim, Salim S. Abdool, editor.
Baxter, Cheryl, editor.
Available in Other Form
Print version: 9783319475172
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Part I. Introduction
Studies Linked to the Evolving HIV Epidemic in South Africa: Informing the CAPRISA Scientific Agenda
CAPRISA: Establishing A Research Center to Undertake HIV Clinical Trials
Overview of Clinical Trials
Part II. CAPRISA Clinical Trials for HIV and HSV-2 Prevention
Antiretrovirals for HIV Prevention
Rolling out of tenofovir gel in family planning clinics: the CAPRISA 008 implementation trial
Conditional cash transfers to reduce HIV risk in young women: the CAPRISA 007 cluster randomised control trial
HIV vaccine and passive immunity trials
Part III: CAPRISA Clinical Trials for HIV?TB Treatment
CAPRISA 003: Timing of antiretroviral initiation in HIV-TB co-infected patients
The SAPiT Trial
Scaling up TB-HIV integration in public health clinics: translating research findings into practice
Part IV: Experiences and lessons learnt from clinical trials in CAPRISA
Lessons from the Acute Infection Study: from Bench to Bedside
Understanding sexual HIV transmission in women by focusing on the genital mucosa
Part V: Essential support activities for the conduct of clinical trials
Good practices in conducting clinical trials: Good Participatory Practice, Good Pharmacy Practice and Good Laboratory Practice
Grants Management
Taking science to the people: communication and media strategies for clinical trials
Looking ahead: What Does the Future Hold for CAPRISA?
Appendix
Index. .

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