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000779256 24500 $$aMolecular pathogenesis and signal transduction by helicobacter pylori /$$cNicole Tegtmeyer, Steffen Backert, editors.
000779256 260__ $$aCham, Switzerland :$$bSpringer,$$c2017.
000779256 300__ $$a1 online resource.
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000779256 4901_ $$aCurrent topics in microbiology and immunology ;$$vvolume 400
000779256 5050_ $$aForeword; Preface; Contents; Abbreviations; 1 The Human Stomach in Health and Disease: Infection Strategies by Helicobacter pylori; Abstract; 1 Introduction; 2 H. pylori Infection and Strategies of Persistence; 3 H. pylori Infection in Health and Disease; 3.1 Gastritis; 3.2 Peptic Ulcer Disease; 3.3 Gastric Adenocarcinoma; 3.4 MALT Lymphoma; 4 H. pylori Virulence Factors and their Association with Disease; 4.1 The cag Pathogenicity Island; 4.2 Vacuolating Cytotoxin (VacA); 4.3 DupA and tfs4; 4.4 NapA; 4.5 Adhesins; 5 Environmental Factors and their Association with Disease.
000779256 5058_ $$a6 Treatment of H. pylori and Prospects for a Vaccine7 Concluding Remarks; Acknowledgements; References; 2 Human and Helicobacter pylori Interactions Determine the Outcome of Gastric Diseases; Abstract; 1 Helicobacter pylori: From Infection to Diseases; 2 The Chemokine CXCL8; 2.1 Induction of CXCL8 by H. pylori; 2.2 CXCL8 Gene Polymorphisms; 3 Induction and Role of ROS; 3.1 ROS During H. pylori Infection; 3.2 Expression and Role of NOX1; 3.3 Expression and Role of NOX2; 3.4 Expression and Role of SMOX; 3.5 Epigenetic Regulation of SMOX; 4 Nitrosative Stress; 4.1 H. pylori Infection and NOS2.
000779256 5058_ $$a4.2 NO-Mediated H. pylori Carcinogenesis4.3 NOS2 Polymorphisms; 5 The Host and Bacteria Coevolution: The Crystal Ball of H. pylori Pathogenesis?; 6 Concluding Remarks; References; 3 Immune Evasion Strategies and Persistence of Helicobacter pylori; Abstract; 1 Introduction; 2 Innate Immune Evasion Strategies of H. pylori; 2.1 Evasion and Manipulation of Pattern Recognition Receptors; 2.1.1 Evasion of TLR Recognition and Manipulation of TLR-Mediated Signaling; 2.1.2 Inhibition of CLR-Mediated Signaling; 2.2 Inhibition of Phagocytosis and Killing by Reactive Oxygen Species and Nitric Oxide.
000779256 5058_ $$a2.3 Inhibition of Antimicrobial Peptides3 Immune Tolerance Driven by H. pylori Interaction with Dendritic Cells; 4 Manipulation and Inhibition of Effector T Cell Responses; 5 Bacterial Plasticity and Immune Evasion; 6 Concluding Remarks; References; 4 Recent Advances in Helicobacter pylori Replication: Possible Implications in Adaptation to a Pathogenic Lifestyle and Perspectives for Drug Design; Abstract; 1 Introduction; 2 Chromosome Replication in Bacteria; 3 Chromosome Replication in Helicobacter pylori; 3.1 Initiation; 3.2 Elongation; 3.3 Termination; 3.4 Segregation.
000779256 5058_ $$a4 Regulation of H. pylori Chromosome Replication5 Plasmid Replication in Bacteria; 6 Plasmid Replication in Helicobacter pylori; 7 Beyond the Replication Flowchart; 8 Concluding Remarks; Acknowledgements; References; 5 The Helicobacter pylori Methylome: Roles in Gene Regulation and Virulence; Abstract; 1 Introduction; 2 The Restriction-Modification (R-M) Systems and Their Diversity in H. pylori; 3 The H. pylori Methylomes; 4 Roles of H. pylori Methyltransferases (Mtases) in Gene Regulation; 4.1 Gene Regulation by E. coli Deoxyadenosine Methyltransferase (Dam) and Its Homologues.
000779256 506__ $$aAccess limited to authorized users.
000779256 520__ $$aThis volume reviews the current state of research concerning bacterial virulence factors and the infection biology of Helicobacter pylori, which is the leading cause of peptic ulcers and gastric cancer worldwide. The chapters include cutting-edge findings on this fascinating microbe and discuss the general strategies of H. pylori infection and persistence, news on important H. pylori virulence factors, crosstalk with the microbiota, hot novel models and signaling mechanisms, risk factors of gastric disease and stomach cancer, and the impact of H. pylori infection on non-gastric diseases. Written by internationally respected scientists, this book will appeal to clinicians, researchers and advanced students alike.
000779256 588__ $$aDescription based on print  version record.
000779256 650_0 $$aHelicobacter pylori infections$$xPathogenesis.
000779256 650_0 $$aPathology, Molecular.
000779256 7001_ $$aTegtmeyer, Nicole,$$eeditor.
000779256 7001_ $$aBackert, Steffen,$$eeditor.
000779256 77608 $$iPrint version:$$tMolecular pathogenesis and signal transduction by helicobacter pylori.$$dCham, Switzerland : Springer, 2017$$z331950519X$$z9783319505190$$w(OCoLC)962354656
000779256 830_0 $$aCurrent topics in microbiology and immunology ;$$v400.
000779256 852__ $$bebk
000779256 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-50520-6$$zOnline Access$$91397441.1
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000779256 983__ $$aOnline
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