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Renal cell carcinoma : molecular features and treatment updates / Mototsugu Oya, editor.

Oya, Mototsugu, editor.
2017
RC280.K5
Available Online
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Title
Renal cell carcinoma : molecular features and treatment updates / Mototsugu Oya, editor.
ISBN
9784431555315 (electronic book)
4431555315 (electronic book)
9784431555308
4431555307
DOI
https://doi.org/10.1007/978-4-431-55531-5
Published
Tokyo, Japan : Springer, 2017.
Language
English
Description
1 online resource (x, 381 pages) : illustrations.
Item Number
10.1007/978-4-431-55531-5 doi
Call Number
RC280.K5
Dewey Decimal Classification
616.99/461
Summary
This book provides a comprehensive review of diagnosis and treatments of renal cell carcinoma (RCC) for practitioners and researchers with an interest in this disease. A major aim of the book is to present the most important and most recent advances in molecular bases and targeted therapy for this neoplasm. The remarkable resistance to chemotherapy and radiotherapy and the minimum contribution of cancer genes that commonly mutate in other adult epithelial cancers have made RCC highly distinct from other types of solid neoplasms. In the past decade, however, treatment options for RCC have been expanding and moving quickly toward laboratory-based and molecular-targeted therapies. Advances in RCC therapy also have brought novel treatment options to other types of cancer, such as a TKI for hepatocellular carcinoma and gastrointestinal tumors, as well as mTOR inhibitors to progressive neuroendocrine tumors of pancreatic origin and to breast cancer, suggesting that RCC is no longer an "orphan disease" in the field of molecular oncology. Additional topics covered in the book include pharmacokinetics and pharmacodynamics in molecular-targeted agents and the putative mechanism of resistance to anti-angiogenic agents, such as intratumoral heterogeneity or cancer stem cell population. This volume provides the latest and most useful information for all readers who are eagerly devoted to curing renal cell carcinoma.
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Access limited to authorized users.
Digital File Characteristics
text file PDF
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed February 23, 2017).
Added Author
Oya, Mototsugu, editor.
Available in Other Form
Print version: 9784431555308
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Chapter 1 Epidemiology of Renal Cell Carcinoma
Chapter 2 Hereditary Renal Cell Carcinoma
Chapter 3 Molecular Genetics of Renal Cell Carcinoma
Chapter 4 Pathology of Renal Cell Carcinoma
Chapter 5 Imaging Features of Renal Cell Carcinoma: Differential Diagnosis, Staging and Post-Treatment Evaluation
Chapter 6 Treatment Overview
Chapter 7 Natural History and Active Surveillance
Chapter 8 Surgical Treatment for Renal Cell Carcinoma
Chapter 9 Predictive and Prognostic Markers in Metastatic Renal Cell Carcinoma
Chapter 10 Tyrosine-Kinase Inhibitors: Sorafenib, Sunitinib, Axitinib, Pazopanib
Chapter 11 Mammalian Targets of Rapamycin Inhibitors: Temsirolimus, Everolimus
Chapter 12 Immunotherapy for Renal Cell Carcinoma (RCC): Including Immune Checkpoint Blockade Therapy
Chapter 13 Treatment for Non-Clear Cell Renal Cell Carcinoma
Chapter 14 Forthcoming Drugs for Metastatic Renal Cell Carcinoma Therapy
Chapter 15 Refractory Mechanisms
Chapter 16 Optimization of Therapy by Pharmacokinetic: Pharmacodynamic Analyses.

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