Directed enzyme evolution : advances and applications / Miguel Alcalde, editor.
Alcalde, Miguel, editor.
2017
QH442
Available Online

Linked e-resources

Linked Resource
Online Access
Concurrent users
Unlimited
Authorized users
Authorized users
Document Delivery Supplied
Can lend chapters, not whole ebooks

Details

Title
Directed enzyme evolution : advances and applications / Miguel Alcalde, editor.
ISBN
9783319504131 (electronic book)
3319504134 (electronic book)
9783319504117
3319504118
DOI
https://doi.org/10.1007/978-3-319-50413-1
Published
Cham, Switzerland : Springer, [2017]
Language
English
Description
1 online resource.
Item Number
10.1007/978-3-319-50413-1 doi
Call Number
QH442
Dewey Decimal Classification
660.6/34
Summary
This book focuses on some of the most significant advances in enzyme engineering that have been achieved through directed evolution and hybrid approaches. On the 25th anniversary of the discovery of directed evolution, this volume is a tribute to the pioneers of this thrilling research field, and at the same time provides a comprehensive overview of current research and the state of the art. Directed molecular evolution has become the most reliable and robust method to tailor enzymes, metabolic pathways or even whole microorganisms with improved traits. By mirroring the Darwinian algorithm of natural selection on a laboratory scale, new biomolecules of invaluable biotechnological interest can now be engineered in a manner that surpasses the boundaries of nature. The volume is divided into two sections, the first of which provides an update on recent successful cases of enzyme ensembles from different areas of the biotechnological spectrum, including tryptophan synthases, unspecific peroxygenases, phytases, therapeutic enzymes, stereoselective enzymes and CO2-fixing enzymes. This section also provides information on the directed evolution of whole cells. The second section of the book summarizes a variety of the most applicable methods for library creation, together with the future trends aimed at bringing together directed evolution and in silico/computational enzyme design and ancestral resurrection.
Bibliography, etc. Note
Includes bibliographical references.
Access Note
Access limited to authorized users.
Digital File Characteristics
text file PDF
Source of Description
Online resource; title from PDF title page (viewed February 23, 2017).
Added Author
Alcalde, Miguel, editor.
Available in Other Form
Print version: 9783319504117
Linked Resources
Online Access
Record Appears in
Online Resources > Ebooks
All Resources
1. Directed evolution for Opsin Engineering (Prof. Frances H. Arnold, Caltech, USA)
2. Directed evolution for enzyme enantio-selectivity (Prof. Manfred T. Reetz, Max-Planck-Institut für Kohlenforschung, Germany)
3. Directed evolution for fuels and chemicals (Prof. Huimin Zhao, University of Urbana-Champaign, Illinois, USA)
4. Directed evolution for cancer biopharmaceuticals (Prof. Dane Wittrup, MIT, USA)
5. Directed evolution of the ligninolytic consortium (Prof. Miguel Alcalde, Institute of Catalysis, CSIC, Madrid, Spain)
6. Directed evolution for engineering of metabolic pathways (Prof. Claudia Schmidt-Dannert, University of Minnesota, USA)
7. Directed evolution and metagenomics (Prof. Kenneth N. Timmis, Technische Universität Braunschweig, Germany)
8. Directed evolution and protein evolvability (Prof. Jesse Bloom, Fred Hutchinson Cancer Research Center, Seattle, USA)
9. Directed evolution for understanding natural evolution (Prof. Dan S. Tawfik, Weizmann Institute of Science, Rehovot, Israel)
10. Diversity methods for directed evolution (Prof. Ullrich Schwaneberg, RWTH-Aachen University, Germany)
11. Ancestral enzymes, evolution and resurrection (Prof. Jose Manuel Sanchez Ruiz, Universidad de Granada, Spain)
12. Directed evolution and computational protein algorithms (Prof. Victor Guallar, Barcelona Supercomputing Center, Spain).

Browse Subjects

Show more subjects...

Statistics

from
to
Export