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Preface; Contents; Part I: Overview; Chapter 1: Metallomics: Integrated Biometal Science; 1.1 Introduction; 1.2 Progress of Analytical Atomic Spectrometry; 1.3 All-Element Present Theory; 1.4 Chemical Speciation of Trace Metals in Biological Samples; 1.5 Human Genome Project and the Rapid Rise of Omics Science; 1.6 Proposal of Metallomics as Integrated Biometal Science-Historical Aspects; 1.7 International Symposium on Metallomics; 1.8 Progress of Metallomics Research; 1.8.1 The Scientific Journal of Metallomics; 1.8.2 Essentiality and Toxicity of the Elements
1.8.3 A Simplified Model of the Biological System1.8.4 Scientific Fields in Trace Metal Science; 1.8.5 Research Subjects in Metallomics; 1.9 Summary; References; Part II: Analytical Techniques and Strategies Surrounding Metallomics; Chapter 2: Speciation and Identification of Chalcogen-Containing Metabolites; 2.1 Introduction; 2.2 Hyphenated Techniques; 2.3 Identification of Chalcogen-Containing Metabolites; 2.3.1 Selenosugars; 2.3.2 Selenohomolanthionine; 2.3.3 Selenoneine; 2.3.4 Selenocyanate; 2.3.5 Trimethyltelluronium Ion; 2.3.6 Te-Methyltellurocysteine; 2.4 Conclusion; References
Chapter 3: Visualization of Intracellular Elements Using Scanning X-Ray Fluorescence Microscopy3.1 Imaging Intracellular Elements at the Single-Cell Level Provides New Insights; 3.2 Scanning X-Ray Fluorescence Microscopy; 3.2.1 Synchrotron Radiation X-Ray Source; 3.2.2 X-Ray Focusing Optics; 3.2.3 Demonstration of SXFM Performance; 3.3 Applications in Biology and Medicine; 3.3.1 SXFM Is Now User-Friendly; 3.3.2 Sample Preparation; 3.3.3 Basement for Cells; 3.3.4 Element Array; 3.3.5 A Cell Line Subjected to Sample Imaging at the Single-Cell Level; 3.3.6 Clinical Samples
3.3.7 Application in Metal Transport with Targeting3.3.8 Transporter; 3.3.9 Cell-Penetrating Peptides (CPPs); 3.4 Future SXFM; 3.4.1 Improvement of X-Ray Sources; 3.4.2 High-Resolution SXFM; 3.4.3 Possible Labeled Probes; 3.4.4 Application of Medical Probes to SXFM; 3.4.5 SXFM Application for Different Types of Microscopy; 3.5 Collaboration on Platforms in Different Fields; 3.6 Conclusion; References; Chapter 4: Quantitative Elemental Bioimaging Protocol Using Femtosecond-Laser Ablation-ICP-Mass Spectrometry Coupled with Glas...; 4.1 Introduction; 4.2 Experimental Protocols
4.2.1 Instrumentations4.2.2 Sample Preparations; 4.2.3 Experiment Procedures; 4.3 Results and Discussion; 4.3.1 Calibration Strategy; 4.3.2 Ablated Volume; 4.3.3 Quantitative Imaging; 4.4 Conclusion; References; Chapter 5: Single Cell Analysis by Using ICP-MS; 5.1 Introduction; 5.2 Overview of Cytometric Analysis by Using ICP-MS; 5.3 ICP Mass Spectrometers for Cytometric Analysis; 5.4 Cell Introduction Devices for Cytometric Analysis; 5.5 Application of Cytometric Analysis by Using ICP-MS; 5.5.1 Highly Sensitive Elemental Analysis by Time-Resolved ICP-MS; 5.5.2 Mass Cytometry
1.8.3 A Simplified Model of the Biological System1.8.4 Scientific Fields in Trace Metal Science; 1.8.5 Research Subjects in Metallomics; 1.9 Summary; References; Part II: Analytical Techniques and Strategies Surrounding Metallomics; Chapter 2: Speciation and Identification of Chalcogen-Containing Metabolites; 2.1 Introduction; 2.2 Hyphenated Techniques; 2.3 Identification of Chalcogen-Containing Metabolites; 2.3.1 Selenosugars; 2.3.2 Selenohomolanthionine; 2.3.3 Selenoneine; 2.3.4 Selenocyanate; 2.3.5 Trimethyltelluronium Ion; 2.3.6 Te-Methyltellurocysteine; 2.4 Conclusion; References
Chapter 3: Visualization of Intracellular Elements Using Scanning X-Ray Fluorescence Microscopy3.1 Imaging Intracellular Elements at the Single-Cell Level Provides New Insights; 3.2 Scanning X-Ray Fluorescence Microscopy; 3.2.1 Synchrotron Radiation X-Ray Source; 3.2.2 X-Ray Focusing Optics; 3.2.3 Demonstration of SXFM Performance; 3.3 Applications in Biology and Medicine; 3.3.1 SXFM Is Now User-Friendly; 3.3.2 Sample Preparation; 3.3.3 Basement for Cells; 3.3.4 Element Array; 3.3.5 A Cell Line Subjected to Sample Imaging at the Single-Cell Level; 3.3.6 Clinical Samples
3.3.7 Application in Metal Transport with Targeting3.3.8 Transporter; 3.3.9 Cell-Penetrating Peptides (CPPs); 3.4 Future SXFM; 3.4.1 Improvement of X-Ray Sources; 3.4.2 High-Resolution SXFM; 3.4.3 Possible Labeled Probes; 3.4.4 Application of Medical Probes to SXFM; 3.4.5 SXFM Application for Different Types of Microscopy; 3.5 Collaboration on Platforms in Different Fields; 3.6 Conclusion; References; Chapter 4: Quantitative Elemental Bioimaging Protocol Using Femtosecond-Laser Ablation-ICP-Mass Spectrometry Coupled with Glas...; 4.1 Introduction; 4.2 Experimental Protocols
4.2.1 Instrumentations4.2.2 Sample Preparations; 4.2.3 Experiment Procedures; 4.3 Results and Discussion; 4.3.1 Calibration Strategy; 4.3.2 Ablated Volume; 4.3.3 Quantitative Imaging; 4.4 Conclusion; References; Chapter 5: Single Cell Analysis by Using ICP-MS; 5.1 Introduction; 5.2 Overview of Cytometric Analysis by Using ICP-MS; 5.3 ICP Mass Spectrometers for Cytometric Analysis; 5.4 Cell Introduction Devices for Cytometric Analysis; 5.5 Application of Cytometric Analysis by Using ICP-MS; 5.5.1 Highly Sensitive Elemental Analysis by Time-Resolved ICP-MS; 5.5.2 Mass Cytometry