Preface; Contents; Contributors; Basics; 1 Anatomical Considerations; Introduction; Anatomy; Conclusions; Compliance with Ethical Requirements; References; 2 Etiopathogenesis; Introduction; Predisposition to Immune Reaction; Pathogenesis; Conclusions; Compliance With Ethical Requirements; References; 3 Clinical Evaluation; Introduction; Clinical Evaluation; History; Symptoms; Signs; Ocular Examination; Systemic Examination; Specific Diseases; Mooren's Ulcer; PUK Associated with Systemic Disease; Rheumatoid Arthritis; Wegener's Granulomatosis; Polyarteritis Nodosa

Ocular and Systemic InfectionsPeripheral Corneal Diseases; Conclusions; Compliance with Ethical Requirements; References; 4 Investigative Modalities; Introduction; Evaluation of Patients with Peripheral Ulcerative Keratitis; Classification of Investigative Modalities; Standard Tests; Tests that May Be Required in Specific Situations; Establishing the Etiology at the Ocular Level; Establishing the Etiology at the Systemic Level; Monitoring for Any Potential Complications and Side Effects of Medications; Conclusions; Compliance with Ethical Requirements; References

5 General Principles of Medical TherapyIntroduction; Salient Features; Basic Principles; Management; Non-Infectious Immuno-Inflammatory Peripheral Ulcers; Infectious Ulcerative Keratitis Affecting the Peripheral Cornea [25]; General Guidelines for Medical Therapy; Treating Active Disease [26, 27]; Primary Anti-inflammatory Agents as Mainstay of Treatment [10, 27, 29, 32-41]; Adjunctive Therapy [33, 42-47]; Recent Advances [8, 9, 39, 40, 48-64]; Conclusions; Compliance With Ethical Requirements; References; 6 General Principles of Surgery; Introduction

Management, Timing and Indications for SurgeryPostoperative Care; Conclusions; Conflict of Interest; References; Clinical Overview; 7 Clinical Syndromes, Classifications, and Differential Diagnosis; Introduction; Salient Features; Differential Diagnosis; Management; Recent Advances; Conclusion; Conflict of Interest Statement; References; 8 Infectious Causes; Introduction; PUK: Infectious Causes; Etiopathogenesis; Diagnosis; Exogenous Infections; Bacterial PUK; Gonococcal PUK; Viral PUK; Fungal PUK; Acanthamoeba PUK; Systemic Infections; Varicella Zoster; Tuberculosis; Syphilis; AIDS

Hepatitis CParinaud and Lyme Disease; Parasitic Diseases and Bacillary Disintery; Infection as PUK Trigger; PUK Secondary Infections; Treatment; Conclusions; Conflict of Interest; References; 9 Noninfectious Causes; Introduction; Clinical Features; Differential Diagnosis; Connective Tissue Diseases; Rheumatoid Arthritis; Wegener's Granulomatosis; Polyarteritis Nodosa; Microscopic Polyangiitis and Churg-Strauss Syndrome; Systemic Lupus Erythematosus; Relapsing Polychondritis; Other Causes of Inflammatory Peripheral Corneal Ulceration; Sarcoidosis; Inflammatory Bowel Disease; Mooren's Ulcer