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000780242 24500 $$aBone morphogenetic proteins :$$bsystems biology regulators /$$cSlobodan Vukicevic, Kuber T. Sampath, editors.
000780242 264_1 $$aCham, Switzerland :$$bSpringer,$$c2017.
000780242 300__ $$a1 online resource (xii, 445 pages) :$$billustrations.
000780242 336__ $$atext$$btxt$$2rdacontent
000780242 337__ $$acomputer$$bc$$2rdamedia
000780242 338__ $$aonline resource$$bcr$$2rdacarrier
000780242 347__ $$atext file$$bPDF$$2rda
000780242 4901_ $$aProgress in inflammation research
000780242 500__ $$aIncludes index.
000780242 504__ $$aReferencesNovel InßVitro Assay Models toßStudy Osteogenesis andßChondrogenesis forßHuman Skeletal Disorders; 1 Phenotypic Markers ofßSkeletal Tissue-Forming Cells; 1.1 Osteoblasts; 1.2 Chondrocytes; 2 C2C12 Myoblasts forßBMP/GDF Research; 2.1 C2C12 Myoblasts; 2.2 Osteoblastic Differentiation ofßC2C12 Myoblasts by BMPs; 2.3 Applications ofßC2C12 Myoblasts forßSignaling Molecules ofßBMPs/GDFs; 2.3.1 Receptors; 2.3.2 Transcription Factors; 2.3.3 Early Response Genes ofßBMP Signaling; 3 Models ofßChondrogenesis; 3.1 Skeletal Muscle Cells.
000780242 5050_ $$aPreface; Contents; List of Contributors; Historical Perspective ofßBone Morphogenetic Proteins; 1 Bone Formation: Auto-induction; 2 Matrix-Induced Bone Formation: AßBiological Cascade; 3 Discovery ofßBone Morphogenetic Proteins; 4 BMP Structure; 5 BMP Receptors; 6 BMP Preclinical Studies; 7 BMP-7 inßArticular Cartilage Repair; 8 BMPs Beyond Bone; 9 BMP Clinical Studies; 10 Conclusion; References; The Systems Biology ofßBone Morphogenetic Proteins; 1 BMPs During Development; 2 Structure andßFunction; 3 BMP: InßVitro andßInßVivo Model Systems forßEndochondral Bone Differentiation.
000780242 5058_ $$a4 Role ofßBMPs inßCartilage Repair andßRegeneration5 Role ofßBMPs inßBone Repair andßRegeneration; 6 BMPs inßDentin Repair andßRegeneration; 7 BMP-7 inßAcute andßChronic Kidney Failure; 8 BMPs inßGlucose Homeostasis; 9 BMP-7 andßCalcium andßPhosphate Homeostasis; 10 BMPs inßIron Homeostasis; 11 BMPs' Role inßRare Genetic Disorders; 12 BMP inßOncology; 13 Conclusion; References; Embryonic Skeletogenesis andßCraniofacial Development; 1 Introduction; 2 Embryonic Skeletogenesis; 2.1 Developmental Stages ofßOssification; 2.2 BMP andßOsteogenesis; 2.3 Functional Studies inßAnimal Models.
000780242 5058_ $$a2.3.1 BMP andßOsteoblasts2.3.2 BMP andßChondrocytes; 2.3.3 BMP andßMesenchymal Cells; 2.3.4 BMP andßOsteoclasts; 2.3.5 BMP andßOther Cell Types inßSkeletal System; 2.4 BMP andßBone-Related Diseases; 3 Craniofacial Development; 3.1 Head Induction; 3.2 Facial Development andßAbnormalities; 3.2.1 BMP andßCleft Lip; 3.2.2 BMP, Facial Cleft, andßMidline Structure; 3.2.3 BMP andßCleft Palate; 3.3 Calvarial Vault andßCranial Base; 3.3.1 BMP andßSkull Formation; 3.3.2 BMP andßSuture Formation; 3.3.3 BMP andßCranial Base; 3.4 Mandibular Development andßTemporomandibular Joint Formation.
000780242 5058_ $$a3.4.1 BMP andßMandible3.4.2 BMP andßtheßTemporomandibular Joint; 4 Perspective andßConclusions; References; BMP andßBMP Regulation: Structure andßFunction; 1 General Mechanisms forßBMP Binding toßBMP Type IßandßType II Receptors; 2 General Mechanisms forßBMP Inhibition andßAntagonism; 3 Noggin-Mediated Antagonism; 4 Follistatin Family-Mediated Antagonism; 5 Chordin Family-Mediated Antagonism; 6 DAN Family-Mediated Antagonism; 7 Prodomain Interactions andßLatent Complex Formation; 8 Co-receptors, Signal Enhancers, andßOther Antagonists; 9 Summary ofßBMP Regulation ThroughßDifferent Mechanisms.
000780242 506__ $$aAccess limited to authorized users.
000780242 520__ $$aThis book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes. This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.
000780242 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed March 24, 2017).
000780242 650_0 $$aBone morphogenetic proteins.
000780242 7001_ $$aVukicevic, Slobodan,$$d1951-$$eeditor.
000780242 7001_ $$aSampath, Kuber T.,$$eeditor.
000780242 77608 $$iPrint version:$$aVukicevic, Slobodan.$$tBone Morphogenetic Proteins: Systems Biology Regulators.$$dCham : Springer International Publishing, ©2017$$z9783319475059
000780242 830_0 $$aPIR (Series)
000780242 852__ $$bebk
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