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000780362 020__ $$a9783319486833$$q(electronic book)
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000780362 0247_ $$a10.1007/978-3-319-48683-3$$2doi
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000780362 08204 $$a616.9/014$$223
000780362 24500 $$aDrug resistance in bacteria, fungi, malaria, and cancer /$$cGunjan Arora, Andaleeb Sajid, Vipin Chandra Kalia, editors.
000780362 264_1 $$aCham, Switzerland :$$bSpringer,$$c[2017].
000780362 264_4 $$c©2017
000780362 300__ $$a1 online resource.
000780362 336__ $$atext$$btxt$$2rdacontent
000780362 337__ $$acomputer$$bc$$2rdamedia
000780362 338__ $$aonline resource$$bcr$$2rdacarrier
000780362 347__ $$atext file$$bPDF$$2rda
000780362 504__ $$aIncludes bibliographical references.
000780362 5050_ $$aPreface; Contents; Author Biographies; Emerging Themes in Drug Resistance; 1 Pharmacogenomics; 1.1 Introduction; 1.2 Role of Pharmacogenomics in Drug Resistance; 1.2.1 Tuberculosis; 1.2.2 Epilepsy; 1.2.3 HIV; 1.3 Role of Pharmacogenomics in Drug Discovery; 2 Therapeutic Antibodies for Bacterial Diseases; 2.1 The Growing Problem of Antimicrobial Resistance; 2.2 The Need for New Therapeutic Interventions; 2.3 The Foundations of Antibody Therapy; 2.4 Antibody Structure; 2.5 Types of Therapeutic Antibody Molecules; 2.6 Clinical Pipeline; 2.6.1 Neutralization of Viruses and Toxins
000780362 5058_ $$a2.6.2 Opsonophagocytic Killing2.6.3 Complement Activation; 2.6.4 Antibody-Drug Conjugates; 2.7 Advantages and Disadvantages of Antibody Therapy; 3 Development of Drug Resistance Through Inter- and Intracellular Communication; 4 Exosome-Mediated Drug Resistance; 4.1 Extracellular Vesicles as Carriers of Drug-Resistant Traits Across Pathologies; 4.2 Vesicle-Mediated Drug Resistance in Noncommunicable Disorders; 4.3 Vesicle-Mediated Drug Resistance in Pathogenic Disorders; 5 Structuromics; 5.1 Role of Structuromics in Deciphering the Drug Resistance Mechanism
000780362 5058_ $$a5.2 Role of Structuromics in Drug Designing6 Posttranslationally Modified Protein Networks as Drug Targets; 7 Conclusions; References; Molecular Mechanism of Drug Resistance: Common Themes; 1 Introduction; 2 Mechanisms of Drug Resistance; 2.1 Intrinsic Resistance; 2.2 Acquired Resistance; 2.2.1 Diminution of Intracellular Antibiotic Load: The External Affairs; 2.2.1.1 Reducing Permeability: The Consular Affairs; 2.2.1.2 Enhancing the Efflux: The Deporting Mechanisms; 2.2.2 Modification of the Target: The Blacking Out; 2.2.2.1 Mutation of the Target
000780362 5058_ $$a2.2.2.2 Protection or Modification of the Target2.2.3 Neutralization of the Antibiotic: Warhead Destruction; 2.2.3.1 Hydrolytic Cleavage of the Antibiotic; 2.2.3.2 Addition of Functional Group; 3 Multi-, Extreme- and Pan-Drug Resistance: The Current Threats; 4 Conclusions and Future Perspectives; References; Molecular Mechanism of Drug Resistance; 1 Introduction; 2 Emergence of Drug Resistance: The Road So Far; 2.1 History of Antibiotic Resistance Development: A Problem Getting Worse; 3 Factors for Drug Resistance Development: The Ongoing Phenomena; 4 General Mechanism of Drug Resistance
000780362 5058_ $$a4.1 Intrinsic Resistance4.2 Acquired Resistance; 5 Drug Resistance Mechanism (Disease Specific); 5.1 Tumor Drug Resistance: An Evolving Paradigm; 5.2 Antibiotic Resistance: The Bacterial Weapons; 5.2.1 Survival Strategies; 5.2.2 Antibiotic Efflux Pump System; 5.2.3 Degradation of Antibiotic; 5.2.4 Alteration of Bacterial Target; 5.3 Tuberculosis: The Unsolved Puzzle; 5.4 Antifungal Drug Resistance; 5.4.1 Antifungal Agents and Their Mechanism of Action; 5.4.2 Ergosterol Biosynthesis Inhibitors (Azoles and Triazoles); 5.4.3 Polyenes; 5.4.4 5-Fluorocytosine: Nucleic Acid Synthesis Inhibitors
000780362 506__ $$aAccess limited to authorized users.
000780362 520__ $$aThis book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer. Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased excessively in last century. The advances in chemistry and biology have helped researchers to identify the drugs that have improved treatment of many diseases. The primary factor for treatment of these diseases is dependent on the efficacy of drugs available. The development of resistance to these drugs is one of the major hindrances. Although there are number of books available on this topic, ℓ́ℓdrug resistanceℓ́ℓ biology across kingdoms has never been discussed in a coherent way.
000780362 588__ $$aVendor-supplied metadata.
000780362 650_0 $$aDrug resistance in microorganisms.
000780362 650_0 $$aDrug resistance in cancer cells.
000780362 7001_ $$aArora, Gunjan,$$eeditor.
000780362 7001_ $$aSajid, Andaleeb,$$eeditor.
000780362 7001_ $$aKalia, Vipin Chandra,$$eeditor.
000780362 77608 $$iPrint version:$$z3319486829$$z9783319486826$$w(OCoLC)959594320
000780362 852__ $$bebk
000780362 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-48683-3$$zOnline Access$$91397441.1
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000780362 980__ $$aBIB
000780362 982__ $$aEbook
000780362 983__ $$aOnline
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