000780515 000__ 02587cam\a2200505Ii\4500 000780515 001__ 780515 000780515 005__ 20230306143143.0 000780515 006__ m\\\\\o\\d\\\\\\\\ 000780515 007__ cr\nn\nnnunnun 000780515 008__ 170403s2017\\\\sz\\\\\\ob\\\\001\0\eng\d 000780515 019__ $$a981708571$$a981852355$$a984854372 000780515 020__ $$a9783319499697$$q(electronic book) 000780515 020__ $$a3319499696$$q(electronic book) 000780515 020__ $$z9783319499673 000780515 020__ $$z331949967X 000780515 0247_ $$a10.1007/978-3-319-49969-7$$2doi 000780515 035__ $$aSP(OCoLC)ocn980874356 000780515 035__ $$aSP(OCoLC)980874356$$z(OCoLC)981708571$$z(OCoLC)981852355$$z(OCoLC)984854372 000780515 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dN$T$$dEBLCP$$dYDX$$dGW5XE$$dUAB$$dNJR$$dIOG$$dCOO$$dAZU$$dUPM$$dOCLCO 000780515 049__ $$aISEA 000780515 050_4 $$aQP356.22 000780515 066__ $$c(S 000780515 08204 $$a612.8$$223 000780515 24500 $$aLeucine-Rich Repeat kinase 2 (LRRK2) /$$cHardy J. Rideout, editor. 000780515 264_1 $$aCham, Switzerland :$$bSpringer,$$c[2017] 000780515 300__ $$a1 online resource. 000780515 336__ $$atext$$btxt$$2rdacontent 000780515 337__ $$acomputer$$bc$$2rdamedia 000780515 338__ $$aonline resource$$bcr$$2rdacarrier 000780515 347__ $$atext file$$bPDF$$2rda 000780515 4901_ $$aAdvances in neurobiology ;$$vvolume 14 000780515 504__ $$aIncludes bibliographical references. 000780515 506__ $$aAccess limited to authorized users. 000780515 520__ $$aThis is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration. 000780515 588__ $$aOnline resource; title from PDF title page (viewed April 05, 2017). 000780515 650_0 $$aNeurogenetics. 000780515 650_0 $$aChromosomes. 000780515 650_0 $$aParkinson's disease$$xGenetic aspects. 000780515 7001_ $$aRideout, Hardy J.,$$eeditor 000780515 77608 $$iPrint version:$$z331949967X$$z9783319499673$$w(OCoLC)961415076 000780515 830_0 $$aAdvances in neurobiology ;$$v14. 000780515 852__ $$bebk 000780515 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-49969-7$$zOnline Access$$91397441.1 000780515 909CO $$ooai:library.usi.edu:780515$$pGLOBAL_SET 000780515 980__ $$aEBOOK 000780515 980__ $$aBIB 000780515 982__ $$aEbook 000780515 983__ $$aOnline 000780515 994__ $$a92$$bISE