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Dedication; Preface; Contents; List of Contributors; Chapter 1: Telencephalic Tissue Formation inß3D Stem Cell Culture; 1.1 Introduction; 1.2 The Cerebral Cortex; 1.2.1 Development ofßtheßCerebral Cortex InßVivo; 1.2.2 3D Cortical Tissue Generation InßVitro; 1.3 Ventralizing Telencephalic Tissues; 1.3.1 Development ofßtheßVentral Telencephalon InßVivo; 1.3.2 Development ofßtheßVentral Telencephalon InßVitro; 1.4 Dorsalizing Telencephalic Tissues; 1.4.1 Development ofßDorsomedial Telencephalic Structure InßVivo; 1.4.2 Generation ofßDorsomedial Telencephalic Tissues InßVitro.
1.5 Closing Remarks andßFuture PerspectiveReferences; Chapter 2: Self-Organized Cerebellar Tissue fromßHuman Pluripotent Stem Cells andßIts Application toßClinical Medicine; 2.1 Introduction; 2.2 Self-Organization ofßCerebellar Tissue fromßhPSCs inß3D Culture; 2.2.1 Development ofßMammalian Cerebellum; 2.2.2 Attempt toßGenerate Cerebellar Neurons fromßPSCs; 2.2.3 Self-Induction ofßCerebellar Neurons fromßhPSCs; 2.2.4 Self-Formation ofßPolarized Cerebellar Structure; 2.3 Construction ofßHuman Cerebellar Disease Models withßPatient-Derived iPSCs; 2.4 Conclusion; References.
Chapter 3: Functional Pituitary Tissue Formation Recapitulating Hypothalamus andßPituitary Development Using ES/iPS Cells3.1 Introduction; 3.2 A Need forßHypothalamus andßAdenohypophysis Regenerative Medicine; 3.3 Mouse Embryonic Stem Cells; 3.4 Pituitary Gland Embryology; 3.5 Three-Dimensional ES Cell Culture; 3.6 Induction ofßHypothalamic Neurons fromßMouse ES Cells; 3.7 Two-Layer Formation InßVitro Is theßFirst Step ofßAdenohypophysis Differentiation; 3.8 Self-Formation ofßRathke's Pouch; 3.9 Differentiation into Hormone-Producing Endocrine Cells; 3.10 Functionality ofßInduced ACTH+ Cells.
3.11 Effect ofßTransplantation intoßHypophysectomized Model Animals3.12 Adaptation toßHuman ES/iPS Cell Culture; 3.13 Future Perspectives; References; Chapter 4: Inner Ear Organoids: Recapitulating Inner Ear Development inß3D Culture; 4.1 Introduction; 4.2 Inner Ear Development; 4.2.1 Formation ofßtheßPreplacodal Region; 4.2.2 Formation ofßtheßOtic Epibranchial Placode Domain; 4.2.3 Formation ofßtheßOtic Placode; 4.3 Generation ofßInner Ear Organoids; 4.3.1 Formation ofßNonneural Ectoderm (NNE); 4.3.2 Formation ofßtheßPreplacodal Region (PPR); 4.3.3 Formation ofßtheßOtic Placode.
4.3.4 Self-Guided Differentiation toßtheßInner Ear Sensory Epithelium4.3.5 Morphologic andßFunctional Analysis ofßInner Ear Sensory Epithelia; 4.4 Potential Applications andßLimitations; References; Chapter 5: Functional Tooth Regeneration; 5.1 Introduction; 5.2 Tooth Organogenesis; 5.3 Tissue Repair andßEngineering byßUsing Dental Tissue-ƯDerived Stem Cells andßCytokines; 5.3.1 Stem-Cell Therapy; 5.3.1.1 Dentin-Pulp Tissue Repair; 5.3.1.2 Periodontal Tissue Repair; 5.3.2 Cytokine Approach; 5.3.3 Bioengineered Root Regeneration byßTissue Engineering Technology.
1.5 Closing Remarks andßFuture PerspectiveReferences; Chapter 2: Self-Organized Cerebellar Tissue fromßHuman Pluripotent Stem Cells andßIts Application toßClinical Medicine; 2.1 Introduction; 2.2 Self-Organization ofßCerebellar Tissue fromßhPSCs inß3D Culture; 2.2.1 Development ofßMammalian Cerebellum; 2.2.2 Attempt toßGenerate Cerebellar Neurons fromßPSCs; 2.2.3 Self-Induction ofßCerebellar Neurons fromßhPSCs; 2.2.4 Self-Formation ofßPolarized Cerebellar Structure; 2.3 Construction ofßHuman Cerebellar Disease Models withßPatient-Derived iPSCs; 2.4 Conclusion; References.
Chapter 3: Functional Pituitary Tissue Formation Recapitulating Hypothalamus andßPituitary Development Using ES/iPS Cells3.1 Introduction; 3.2 A Need forßHypothalamus andßAdenohypophysis Regenerative Medicine; 3.3 Mouse Embryonic Stem Cells; 3.4 Pituitary Gland Embryology; 3.5 Three-Dimensional ES Cell Culture; 3.6 Induction ofßHypothalamic Neurons fromßMouse ES Cells; 3.7 Two-Layer Formation InßVitro Is theßFirst Step ofßAdenohypophysis Differentiation; 3.8 Self-Formation ofßRathke's Pouch; 3.9 Differentiation into Hormone-Producing Endocrine Cells; 3.10 Functionality ofßInduced ACTH+ Cells.
3.11 Effect ofßTransplantation intoßHypophysectomized Model Animals3.12 Adaptation toßHuman ES/iPS Cell Culture; 3.13 Future Perspectives; References; Chapter 4: Inner Ear Organoids: Recapitulating Inner Ear Development inß3D Culture; 4.1 Introduction; 4.2 Inner Ear Development; 4.2.1 Formation ofßtheßPreplacodal Region; 4.2.2 Formation ofßtheßOtic Epibranchial Placode Domain; 4.2.3 Formation ofßtheßOtic Placode; 4.3 Generation ofßInner Ear Organoids; 4.3.1 Formation ofßNonneural Ectoderm (NNE); 4.3.2 Formation ofßtheßPreplacodal Region (PPR); 4.3.3 Formation ofßtheßOtic Placode.
4.3.4 Self-Guided Differentiation toßtheßInner Ear Sensory Epithelium4.3.5 Morphologic andßFunctional Analysis ofßInner Ear Sensory Epithelia; 4.4 Potential Applications andßLimitations; References; Chapter 5: Functional Tooth Regeneration; 5.1 Introduction; 5.2 Tooth Organogenesis; 5.3 Tissue Repair andßEngineering byßUsing Dental Tissue-ƯDerived Stem Cells andßCytokines; 5.3.1 Stem-Cell Therapy; 5.3.1.1 Dentin-Pulp Tissue Repair; 5.3.1.2 Periodontal Tissue Repair; 5.3.2 Cytokine Approach; 5.3.3 Bioengineered Root Regeneration byßTissue Engineering Technology.