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Squamous cell carcinoma : molecular therapeutic targets / Saman Warnakulasuriya, Zakir Khan, editors.

Warnakulasuriya, S. (Saman), editor.; Khan, Zakir, 1979- editor.
2017
RC280.S5
Available Online
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Title
Squamous cell carcinoma : molecular therapeutic targets / Saman Warnakulasuriya, Zakir Khan, editors.
ISBN
9789402410846 (electronic book)
9402410848 (electronic book)
9789402410839
940241083X
DOI
https://doi.org/10.1007/978-94-024-1084-6
Published
Dordrecht, Netherlands : Springer, 2017.
Language
English
Description
1 online resource : illustrations
Item Number
10.1007/978-94-024-1084-6 doi
Call Number
RC280.S5
Dewey Decimal Classification
616.99/477
Summary
This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine. The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer. Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and their therapeutic applications for targeted therapies based on clinical trials reported worldwide. This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.
Note
Includes index.
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Access limited to authorized users.
Digital File Characteristics
text file PDF
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed April 6, 2017).
Added Author
Warnakulasuriya, S. (Saman), editor.
Khan, Zakir, 1979- editor.
Available in Other Form
Print version: 9789402410839
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Preface
Foreword.-Introduction- The biology and pathology of squamous cell carcinomata in the head and neck
Cancer Stem Cells
Biopathology with reference to Head & Neck Cancers
Hypoxia in head and neck cancer
Genetic aberrations and molecular pathways in head and neck cancer
p53 in Head and Neck Squamous Cell Carcinoma
Blockage of EGFR pathway for anticancer therapy in squamous cell carcinoma of the head and neck
Targeting the mTOR signaling circuitry in head and neck cancer
Survivin as a Therapeutic Target in Squamous Cell Carcinoma
MicroRNA: utility as biomarkers and therapeutic targets in squamous cell carcinoma
Envoi – An appraisal of Targeted Therapies for Head and Neck Cancer
Index.

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