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2 SBRT and the Treatment of Oligometastatic DiseaseAbstract; 1 The Oligometastatic Hypothesis; 2 Biology of Oligometastases; 3 Defining "Oligo" Metastases; 4 Surgical Resection of Limited Metastases; 5 Using SBRT for Extracranial Oligometastases; 6 First, Do No Harm?; 7 SBRT Treatment Planning; 8 Future Directions; 8.1 Combining SBRT with PD-1 Blockade; 8.2 Biological Prognostic and Predictive Tools; 9 Ongoing Clinical Trials; 10 A Cautionary Tale; References; 3 MRI Guided Radiotherapy; Abstract; 1 Radiation Therapy Workflow and Where MR Can and Does Help; 2 MR Simulation; 3 MR + RT
3.1 ViewRay MRIdian3.2 Commercial Units; 3.2.1 ViewRay; 3.2.2 Phillips/Elekta; 3.2.3 MagneTx; 4 Clinical Challenges of MR + RT: Lorenz Force and Radiation Dosimetry; References; 4 Oncologic Applications of Magnetic Resonance Guided Focused Ultrasound; Abstract; 1 Introduction; 2 Clinical Applications of MRgFUS; 2.1 Bone Metastases; 2.2 Breast Cancer; 2.3 Prostate Cancer; 2.4 Brain Cancer; 2.5 Liver Cancer; 2.6 Pancreatic Cancer; 2.7 Soft Tissue Tumors; 2.8 Cervical Cancer; 2.9 Colorectal Cancer; 2.10 Emerging Clinical Applications of MRgFUS; 3 Future Directions; 3.1 Targeted Drug Delivery
3.2 Image Optimization3.2.1 Image Fusion; 3.2.2 Synergistic MR and US Contrast Agents; 3.3 Multimodality MRgFUS Treatments; 4 Concluding Remarks; References; 5 Intensity-Modulated Proton Beam Therapy of Prostate Cancer-History, Results, and Future Directions; Abstract; 1 Introduction; 2 Technical Aspects of Proton Therapy; 3 Treatment Planning; 4 Early Proton Beam Treatment Results; 5 PROG 95-09 Trial; 6 University of Florida Experience; 7 Intensity-Modulated Proton Therapy; 8 IMPT-Examples; 9 Conclusion; References; 6 IGRT and Hypofractionation for Primary Tumors; Abstract; 1 Introduction
2 Non-small Cell Lung Cancer (NSCLC)3 Prostate Cancer-Intact Gland; 4 Prostate Cancer Following Prostatectomy; 5 Pancreatic Cancer; 6 Image-Guided Therapy; 7 Conclusions; References; 7 The Impact of IGRT on Normal Tissue Toxicity; Abstract; 1 Introduction; 2 Radiobiological Foundations; 2.1 A Brief History; 2.2 Some Biological Considerations; 3 Fractionation Scenarios; 3.1 Conventionally Fractionated Treatments; 3.2 Hypofractionated Treatment; 3.3 Single Fraction Treatments; 4 Conclusions; References; 8 Biologic and Image Guided Systemic Radiotherapy; Abstract; 1 Introduction
3.1 ViewRay MRIdian3.2 Commercial Units; 3.2.1 ViewRay; 3.2.2 Phillips/Elekta; 3.2.3 MagneTx; 4 Clinical Challenges of MR + RT: Lorenz Force and Radiation Dosimetry; References; 4 Oncologic Applications of Magnetic Resonance Guided Focused Ultrasound; Abstract; 1 Introduction; 2 Clinical Applications of MRgFUS; 2.1 Bone Metastases; 2.2 Breast Cancer; 2.3 Prostate Cancer; 2.4 Brain Cancer; 2.5 Liver Cancer; 2.6 Pancreatic Cancer; 2.7 Soft Tissue Tumors; 2.8 Cervical Cancer; 2.9 Colorectal Cancer; 2.10 Emerging Clinical Applications of MRgFUS; 3 Future Directions; 3.1 Targeted Drug Delivery
3.2 Image Optimization3.2.1 Image Fusion; 3.2.2 Synergistic MR and US Contrast Agents; 3.3 Multimodality MRgFUS Treatments; 4 Concluding Remarks; References; 5 Intensity-Modulated Proton Beam Therapy of Prostate Cancer-History, Results, and Future Directions; Abstract; 1 Introduction; 2 Technical Aspects of Proton Therapy; 3 Treatment Planning; 4 Early Proton Beam Treatment Results; 5 PROG 95-09 Trial; 6 University of Florida Experience; 7 Intensity-Modulated Proton Therapy; 8 IMPT-Examples; 9 Conclusion; References; 6 IGRT and Hypofractionation for Primary Tumors; Abstract; 1 Introduction
2 Non-small Cell Lung Cancer (NSCLC)3 Prostate Cancer-Intact Gland; 4 Prostate Cancer Following Prostatectomy; 5 Pancreatic Cancer; 6 Image-Guided Therapy; 7 Conclusions; References; 7 The Impact of IGRT on Normal Tissue Toxicity; Abstract; 1 Introduction; 2 Radiobiological Foundations; 2.1 A Brief History; 2.2 Some Biological Considerations; 3 Fractionation Scenarios; 3.1 Conventionally Fractionated Treatments; 3.2 Hypofractionated Treatment; 3.3 Single Fraction Treatments; 4 Conclusions; References; 8 Biologic and Image Guided Systemic Radiotherapy; Abstract; 1 Introduction