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Foreword; Preface; Contents; Contributors; 1 RLS/WED: Criteria, Prevalence, and Differential Diagnosis; Diagnostic Criteria: Historical Aspects; 2012 IRLSSG Consensus Diagnostic Criteria; International Classification of Sleep Disorders, Third Edition (Icsd-3) Diagnostic Criteria for Rls/Wed; Diagnostic Statistical Manual of Mental Disorders, Fifth Edition (Dsm-5) Diagnostic Criteria for Rls/Wed; Differential Diagnosis; Prevalence of Occurrence; References; Long Term Health Consequences of Restless Legs Syndrome/Willis-Ekbom Disease; 2 Mental Health Disorders Associated with RLS
Epidemiology of RLS and Mental HealthDepression and Anxiety in RLS Patients; RLS in Mental Health Cohorts; Explaining the Comorbidity Between RLS and Mental Illness; Depression and Anxiety; RLS and Neurocognitive Impairment; RLS and Attention-Deficit/Hyperactivity Disorder; RLS and Personality; Psychotropics and RLS; Serotonergic Antidepressants and RLS; Other Antidepressants; Sedative-Hypnotics; Neuroleptic Agents; Mood Stabilizers; Psychiatric Considerations of RLS Treatment; Treatment Implications; Conclusions; References
3 Sleep Impact: Insomnia, Hypersomnia, Sleep Attacks, and Circadian DisordersInsomnia; Excessive Daytime Sleepiness; Sleep Attacks; Circadian Disorders; Conclusions; References; 4 Cognitive Functioning; Treatment and Cognitive Function in RLS; Effects of Acute Treatment on Cognitive Function in Subjects with RLS; Prolonged Treatment and Cognitive Function in RLS; Pramipexole; Gabapentin Enarcabil; Summary, Discussion and Outlook; References; 5 Health-Related Quality of Life and Depression Symptom Measures for the Assessment of Treatment in Restless Legs Syndrome/ Willis-Ekbom Disease
Generic Instruments Used in RLS/WEDDisease-Specific Questionnaires Used in RLS/WED; RLS and Depression; References; 6 Epidemiologic Evidence in Cardiovascular Disease; RLS and Cardiovascular Diseases; RLS and Cardiovascular Risk Factors; Obesity; Hypertension; Hyperlipidemia; Epidemiologic Studies of RLS and CVD Risk; Cross-sectional Studies; Prospective Studies; Potential Biological Mechanisms; Periodic Limb Movements During Sleep; PLMS Prevalence and Comorbidities; PLMS and Hypertension; PLMS in Chronic Disease; PLMS and Cardiovascular Disease; References
7 Heart Rate and Blood Pressure Changes Associated with Periodic Limb MovementsHR and BP Correlate of LMS in Controls and Patients; Heart Rate and PLMS; Blood Pressure and PLMS; Effects of the Interaction Between PLMS and Apnea on HR and BP; Searching for the Effects of PLMS-Related Rises in HR and BP; Systemic Hypertension and PLMS; Heart Disease and PLMS; Stroke and PLMS; Challenging the Cause/Effect Relationship Between PLMS and EEG or Autonomic Activations; References
Epidemiology of RLS and Mental HealthDepression and Anxiety in RLS Patients; RLS in Mental Health Cohorts; Explaining the Comorbidity Between RLS and Mental Illness; Depression and Anxiety; RLS and Neurocognitive Impairment; RLS and Attention-Deficit/Hyperactivity Disorder; RLS and Personality; Psychotropics and RLS; Serotonergic Antidepressants and RLS; Other Antidepressants; Sedative-Hypnotics; Neuroleptic Agents; Mood Stabilizers; Psychiatric Considerations of RLS Treatment; Treatment Implications; Conclusions; References
3 Sleep Impact: Insomnia, Hypersomnia, Sleep Attacks, and Circadian DisordersInsomnia; Excessive Daytime Sleepiness; Sleep Attacks; Circadian Disorders; Conclusions; References; 4 Cognitive Functioning; Treatment and Cognitive Function in RLS; Effects of Acute Treatment on Cognitive Function in Subjects with RLS; Prolonged Treatment and Cognitive Function in RLS; Pramipexole; Gabapentin Enarcabil; Summary, Discussion and Outlook; References; 5 Health-Related Quality of Life and Depression Symptom Measures for the Assessment of Treatment in Restless Legs Syndrome/ Willis-Ekbom Disease
Generic Instruments Used in RLS/WEDDisease-Specific Questionnaires Used in RLS/WED; RLS and Depression; References; 6 Epidemiologic Evidence in Cardiovascular Disease; RLS and Cardiovascular Diseases; RLS and Cardiovascular Risk Factors; Obesity; Hypertension; Hyperlipidemia; Epidemiologic Studies of RLS and CVD Risk; Cross-sectional Studies; Prospective Studies; Potential Biological Mechanisms; Periodic Limb Movements During Sleep; PLMS Prevalence and Comorbidities; PLMS and Hypertension; PLMS in Chronic Disease; PLMS and Cardiovascular Disease; References
7 Heart Rate and Blood Pressure Changes Associated with Periodic Limb MovementsHR and BP Correlate of LMS in Controls and Patients; Heart Rate and PLMS; Blood Pressure and PLMS; Effects of the Interaction Between PLMS and Apnea on HR and BP; Searching for the Effects of PLMS-Related Rises in HR and BP; Systemic Hypertension and PLMS; Heart Disease and PLMS; Stroke and PLMS; Challenging the Cause/Effect Relationship Between PLMS and EEG or Autonomic Activations; References