Linked e-resources
Details
Table of Contents
Preface; Contents; Contributors; 1: Wave Theory of Image Formation in a Microscope: Basic Theory and Experiments; 1.1 Introduction; 1.2 Philosophy of This Chapter; 1.3 Building the Demonstration Apparatus; 1.4 Fundamental Concept: The Huygens-Fresnel Principle; 1.5 Diffraction from an Arbitrary Distribution of Scatterers; 1.6 Forming an Image: The Double Fourier Transform; 1.7 Sharpness of the Image and Resolution; 1.8 Summary; Problems; Solution; Further Study; References; 2: Recording of Ionic Currents Under Physiological Conditions: Action Potential-Clamp and Onion-Peeling Techniques
2.1 Introduction2.2 The Principles of the AP-Clamp Technique; 2.3 A Short Historical Review; 2.4 Variations of the AP-Clamp Technique; 2.4.1 Using `Typical ́or `Standardized ́AP; 2.4.2 Using `Modified ́or `Reconstructed ́AP; 2.4.3 Dynamic Clamp; 2.4.4 The selfAP-Clamp Technique; 2.4.5 The AP-Clamp Sequential Dissection or `Onion-Peeling ́Technique; 2.5 Applications of the AP-Clamp Methods; 2.5.1 Study of the Individual Cell Electrophysiology (ICE); 2.5.2 Mapping the Regional and Transmural Differences; 2.5.3 Studying the Complex Effects of Pathological Conditions
2.5.4 Characterization of Drug Effects2.6 Technical Aspects; 2.6.1 Cell Quality and the Solutions; 2.6.2 The Patch Pipette and the Whole-Cell Seal Configuration; 2.6.3 Instrumentation; 2.7 Channel Inhibitors; 2.8 Conclusion; Problems; Solutions; Further Study; References; 3: Patch Clamp Technique and Applications; 3.1 Introduction; 3.2 Basic Recording Setup; 3.3 Patch Clamp Configurations; 3.4 Seal Resistance; 3.5 Series Resistance; 3.6 Sources of Noise; 3.7 Current Clamp Mode; 3.8 Voltage Clamp Mode; 3.9 Summary; Problem; Solution; Further Study; References
4: Structural Insights from Membrane Small-Angle X-ray Diffraction with Anomalous X-ray Scattering4.1 Introduction; 4.2 Background; 4.3 Membrane Diffraction; 4.4 The Physics of Anomalous Scattering; 4.5 Small-Angle X-ray Scattering from AChR-Enriched Membranes; 4.6 Summary and Future Work; Problems; Solutions; Thoughts on Problem 1; Thoughts on Problem 2; Thoughts on Problem 3; Further Study; References; 5: Computer Simulations and Nonlinear Dynamics of Cardiac Action Potentials; 5.1 Introduction; 5.2 Cardiac Action Potential; 5.3 Modeling of Cell Membrane and Channel Gating
5.4 Single Cell Simulation5.5 APD Restitution and Alternans; 5.6 Cardiac Tissue; 5.7 Tissue Simulation: 1D Cable; 5.8 Tissue Simulation: Spatially Discordant Alternans; 5.9 Tissue Simulation: 2D Tissue; 5.10 Ventricular Tachycardia and Fibrillation; 5.11 Parallel Computing (OpenMP); 5.12 Parallel Computing (CUDA); 5.13 Summary; Problems; Solutions; Further Study; References; 6: Hemoglobin and Myoglobin Contribution to the NIRS Signal in Skeletal Muscle; 6.1 Introduction; 6.2 Near-Infrared Spectroscopy; 6.3 Source of the NIRS Signal in Skeletal Muscle
2.1 Introduction2.2 The Principles of the AP-Clamp Technique; 2.3 A Short Historical Review; 2.4 Variations of the AP-Clamp Technique; 2.4.1 Using `Typical ́or `Standardized ́AP; 2.4.2 Using `Modified ́or `Reconstructed ́AP; 2.4.3 Dynamic Clamp; 2.4.4 The selfAP-Clamp Technique; 2.4.5 The AP-Clamp Sequential Dissection or `Onion-Peeling ́Technique; 2.5 Applications of the AP-Clamp Methods; 2.5.1 Study of the Individual Cell Electrophysiology (ICE); 2.5.2 Mapping the Regional and Transmural Differences; 2.5.3 Studying the Complex Effects of Pathological Conditions
2.5.4 Characterization of Drug Effects2.6 Technical Aspects; 2.6.1 Cell Quality and the Solutions; 2.6.2 The Patch Pipette and the Whole-Cell Seal Configuration; 2.6.3 Instrumentation; 2.7 Channel Inhibitors; 2.8 Conclusion; Problems; Solutions; Further Study; References; 3: Patch Clamp Technique and Applications; 3.1 Introduction; 3.2 Basic Recording Setup; 3.3 Patch Clamp Configurations; 3.4 Seal Resistance; 3.5 Series Resistance; 3.6 Sources of Noise; 3.7 Current Clamp Mode; 3.8 Voltage Clamp Mode; 3.9 Summary; Problem; Solution; Further Study; References
4: Structural Insights from Membrane Small-Angle X-ray Diffraction with Anomalous X-ray Scattering4.1 Introduction; 4.2 Background; 4.3 Membrane Diffraction; 4.4 The Physics of Anomalous Scattering; 4.5 Small-Angle X-ray Scattering from AChR-Enriched Membranes; 4.6 Summary and Future Work; Problems; Solutions; Thoughts on Problem 1; Thoughts on Problem 2; Thoughts on Problem 3; Further Study; References; 5: Computer Simulations and Nonlinear Dynamics of Cardiac Action Potentials; 5.1 Introduction; 5.2 Cardiac Action Potential; 5.3 Modeling of Cell Membrane and Channel Gating
5.4 Single Cell Simulation5.5 APD Restitution and Alternans; 5.6 Cardiac Tissue; 5.7 Tissue Simulation: 1D Cable; 5.8 Tissue Simulation: Spatially Discordant Alternans; 5.9 Tissue Simulation: 2D Tissue; 5.10 Ventricular Tachycardia and Fibrillation; 5.11 Parallel Computing (OpenMP); 5.12 Parallel Computing (CUDA); 5.13 Summary; Problems; Solutions; Further Study; References; 6: Hemoglobin and Myoglobin Contribution to the NIRS Signal in Skeletal Muscle; 6.1 Introduction; 6.2 Near-Infrared Spectroscopy; 6.3 Source of the NIRS Signal in Skeletal Muscle