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Table of Contents
Preface
Emerging Viruses: From Early Detection to Intervention; References; How to Tackle Natural Focal Infections: From Risk Assessment to Vaccination Strategies; 1 Eco-Epidemiology: How to Predict and Control the Occurrence of Natural Focal Infectious Diseases; 1.1 Ecological Niche Modelling; 1.2 The Boosted Regression Trees Method; 1.3 Macroecology; 2 Natural Focal Diseases Mapping and Control: Two Paradigmatic Examples; 2.1 Crimean-Congo Hemorrhagic Fever: A Mapping Exercise; 2.2 A Vaccine for CCHF: Give Prevention a Chance
2.3 Tick Borne Encephalitis: Vaccine Use to Control a Natural Focal Disease3 Conclusions; References; Human-Animal Interface: The Case for Influenza Interspecies Transmission; 1 Introduction; 2 The Viruses; 3 Molecular Determinants of Host-Range Restriction and Pathogenesis; 3.1 Hemagglutinin and Receptor-Binding Specificity; 3.2 Other Virulence Determinants; 4 Pandemic Influenza; 5 Animal Influenza; 5.1 Wild Bird-Domestic Bird Interface; 5.2 Domestic Bird-Mammalian Interface; 5.2.1 Domestic Poultry; 5.2.2 Swine Influenza; 6 Increasing Threats of Influenza at the Human-Animal Interface
Changing Conditions that Favor Influenza Transmissibility7 Conclusions; References; Bats and Emerging Infections: An Ecological and Virological Puzzle; 1 Introduction; 2 Why the Bats Are Good Virus Reservoirs?; 2.1 Evolution and Phylogeny of Bats; 2.2 Species Richness; 2.3 Ability to Fly; 2.4 Long Lifespan and Bat Ecology; 3 Virus Dynamic in Bat Populations; 4 Changes in Ecology and Management of Bat Populations; 5 Risk Factors and Prevention Tasks; References; The Middle East Respiratory Syndrome Coronavirus
A Continuing Risk to Global Health Security; 1 Introduction
2 Epidemiological Features of MERS-CoV2.1 Discovery and Evolution; 2.2 Geographical Distribution; 2.3 Origin and Transmission of MERS-CoV; 2.4 Natural History and Pathogenesis; 3 Clinical Presentation; 4 Laboratory Diagnosis and Diagnostics; 5 Management of Mers Patients; 6 Infection Control and Transmission Risk; 7 Surveillance, Prevention and Control; References; Emerging Zika Virus Infection: A Rapidly Evolving Situation; 1 Introduction; 2 Geographic Distribution; 3 ZIKA Virus as Health Emergency of International Concern; 4 Phylogenesis; 5 Vectors and Reservoirs; 6 Flavivirus Structure
7 Mode of Transmission7.1 Mosquitoe-Borne ZIKV Transmission; 7.2 Sexual ZIKV Transmission; 7.3 Blood Transfusion and Transplantation ZIKV Transmission; 7.4 Vertical ZIKV Transmission; 7.5 Human-To-Human ZIKV Transmission; 8 Clinical Manifestations; 8.1 Typical ZIKV Manifestation; 8.2 ZIKV-Associated Guillain-Barré Syndrome; 8.3 ZIKV-Associated Neurological Disorders; 8.4 ZIKV-Associated Microcephaly; 9 Diagnosis; 10 Biological Basis for Pathogenetic Effects; 11 Perspective for ZIKV Control and Treatment; 11.1 Vector Control; 11.2 Vaccine Development; 11.3 Therapeutics; 12 Conclusions
Emerging Viruses: From Early Detection to Intervention; References; How to Tackle Natural Focal Infections: From Risk Assessment to Vaccination Strategies; 1 Eco-Epidemiology: How to Predict and Control the Occurrence of Natural Focal Infectious Diseases; 1.1 Ecological Niche Modelling; 1.2 The Boosted Regression Trees Method; 1.3 Macroecology; 2 Natural Focal Diseases Mapping and Control: Two Paradigmatic Examples; 2.1 Crimean-Congo Hemorrhagic Fever: A Mapping Exercise; 2.2 A Vaccine for CCHF: Give Prevention a Chance
2.3 Tick Borne Encephalitis: Vaccine Use to Control a Natural Focal Disease3 Conclusions; References; Human-Animal Interface: The Case for Influenza Interspecies Transmission; 1 Introduction; 2 The Viruses; 3 Molecular Determinants of Host-Range Restriction and Pathogenesis; 3.1 Hemagglutinin and Receptor-Binding Specificity; 3.2 Other Virulence Determinants; 4 Pandemic Influenza; 5 Animal Influenza; 5.1 Wild Bird-Domestic Bird Interface; 5.2 Domestic Bird-Mammalian Interface; 5.2.1 Domestic Poultry; 5.2.2 Swine Influenza; 6 Increasing Threats of Influenza at the Human-Animal Interface
Changing Conditions that Favor Influenza Transmissibility7 Conclusions; References; Bats and Emerging Infections: An Ecological and Virological Puzzle; 1 Introduction; 2 Why the Bats Are Good Virus Reservoirs?; 2.1 Evolution and Phylogeny of Bats; 2.2 Species Richness; 2.3 Ability to Fly; 2.4 Long Lifespan and Bat Ecology; 3 Virus Dynamic in Bat Populations; 4 Changes in Ecology and Management of Bat Populations; 5 Risk Factors and Prevention Tasks; References; The Middle East Respiratory Syndrome Coronavirus
A Continuing Risk to Global Health Security; 1 Introduction
2 Epidemiological Features of MERS-CoV2.1 Discovery and Evolution; 2.2 Geographical Distribution; 2.3 Origin and Transmission of MERS-CoV; 2.4 Natural History and Pathogenesis; 3 Clinical Presentation; 4 Laboratory Diagnosis and Diagnostics; 5 Management of Mers Patients; 6 Infection Control and Transmission Risk; 7 Surveillance, Prevention and Control; References; Emerging Zika Virus Infection: A Rapidly Evolving Situation; 1 Introduction; 2 Geographic Distribution; 3 ZIKA Virus as Health Emergency of International Concern; 4 Phylogenesis; 5 Vectors and Reservoirs; 6 Flavivirus Structure
7 Mode of Transmission7.1 Mosquitoe-Borne ZIKV Transmission; 7.2 Sexual ZIKV Transmission; 7.3 Blood Transfusion and Transplantation ZIKV Transmission; 7.4 Vertical ZIKV Transmission; 7.5 Human-To-Human ZIKV Transmission; 8 Clinical Manifestations; 8.1 Typical ZIKV Manifestation; 8.2 ZIKV-Associated Guillain-Barré Syndrome; 8.3 ZIKV-Associated Neurological Disorders; 8.4 ZIKV-Associated Microcephaly; 9 Diagnosis; 10 Biological Basis for Pathogenetic Effects; 11 Perspective for ZIKV Control and Treatment; 11.1 Vector Control; 11.2 Vaccine Development; 11.3 Therapeutics; 12 Conclusions