Transient receptor potential canonical channels and brain diseases / Yizheng Wang, editor.
Wang, Yizheng (Neuroscientist), editor.
2017
RC346
Available Online

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Title
Transient receptor potential canonical channels and brain diseases / Yizheng Wang, editor.
ISBN
9789402410884 (electronic book)
9402410880 (electronic book)
9789402410860
9402410864
DOI
https://doi.org/10.1007/978-94-024-1088-4
Published
Dordrecht, the Netherlands : Springer, [2017]
Copyright
©2017
Language
English
Description
1 online resource (viii, 165 pages) : illustrations.
Item Number
10.1007/978-94-024-1088-4 doi
Call Number
RC346
Dewey Decimal Classification
616.80427
Summary
"This book discusses the latest findings on the physiological and pathological functions of transient receptor potential canonical/classical (TRPC) proteins in the brain. In addition to reviewing the functions of TRPCs in brain development and neuron transmission, it mainly covers the potential roles of TRPCs in brain disorders. TRPC proteins belong to the TRP channel superfamily, which has around 30 members. Just like TRP channels, TRPCs are non-selectively permeable to cations, with a selectivity of calcium over sodium that varies among different members. The TRPC subfamily consists of six members, grouped on the basis of the similarities in gene sequence and protein structure in mammalians. What sets TRPCs apart from other subfamilies in TRPs is that their activation, stimulated by a membrane receptor-phospholipid C (PLC) cascade, contributes to the slow and sustained elevation of intracellular free calcium. Calcium ions, one of the most important types of second messengers, mediate a variety of physiological functions in the brain, including progenitor cell proliferation, dendritic formation, synaptic transmission and neuronal survival. All TRPCs except TRPC7 have been found in various regions of the brain, including the cerebrum, cerebellum, forebrain and hippocampus. This book provides students and investigators with comprehensive information on the regulation, function and potential of TRPCs and brain diseases in order to attract more attention to this field"--Publisher's description.
Bibliography, etc. Note
Includes bibliographical references.
Access Note
Access limited to authorized users.
Source of Description
Description based on online resource; title from resource home page (SpringerLink, viewed May 24, 2017).
Added Author
Wang, Yizheng (Neuroscientist), editor.
Series
Advances in experimental medicine and biology ; v. 976.
Available in Other Form
Transient receptor potential canonical channels and brain diseases.
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Record Appears in
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All Resources
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TRPC channels and programmed cell death / Jian Zhou, Yichang Jia
TRPC channels and stroke / Junbo Huang
TRPC channels and Alzheimer's disease / Rui Lu, Qian He, Junfeng Wang
TRPC channels and Parkinson's disease / Pramod Sukumaran, Yuyang Sun, Anne Schaar, Senthil Selvaraj, Brij B. Singh
TRPC channels and neuron development, plasticity, and activities / Yilin Tai, Yichang Jia
TRPC channels and brain inflammation / Yoshito Mizoguchi, Akira Monji
TRPC channels and epilepsy / Fang Zheng
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TRPC channels and cell proliferation / Cheng Zhan, Yu Shi
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