000786605 000__ 05601cam\a2200589Ii\4500 000786605 001__ 786605 000786605 005__ 20210515131433.0 000786605 006__ m\\\\eo\\d\\\\\\\\ 000786605 007__ cr\cn\nnnunnun 000786605 008__ 160819s2016\\\\caua\\\foab\\\000\0\eng\d 000786605 020__ $$a9781615047215$$qelectronic 000786605 020__ $$a1615047212$$qelectronic 000786605 020__ $$z9781615047208 000786605 0247_ $$a10.4199/C00140ED2V01Y201606ISP065$$2doi 000786605 035__ $$a(NhCcYBP)EBC4662060 000786605 040__ $$aNhCcYBP$$cNhCcYBP 000786605 050_4 $$aQP99.3.O9$$bP387 2016 000786605 08204 $$a599.012$$223 000786605 1001_ $$aPittman, Roland N.,$$eauthor. 000786605 24510 $$aRegulation of tissue oxygenation /$$cRoland N. Pittman. 000786605 250__ $$aSecond edition. 000786605 264_1 $$a[San Rafael, California] :$$bMorgan & Claypool,$$c2016. 000786605 300__ $$a1 online resource (xiii, 99 pages) :$$billustrations. 000786605 336__ $$atext$$2rdacontent 000786605 337__ $$aelectronic$$2isbdmedia 000786605 338__ $$aonline resource$$2rdacarrier 000786605 4901_ $$aColloquium series on integrated systems physiology,$$x2154-5626 ;$$v# 65 000786605 500__ $$aPart of: Colloquium digital library of life sciences. 000786605 504__ $$aIncludes bibliographical references (pages 89-98). 000786605 5050_ $$a1. Introduction -- 000786605 5058_ $$a2. The circulatory system and oxygen transport -- 2.1 Design of the cardiovascular system -- 2.2 Hemodynamics -- 2.2.1 Flow of blood through single vessels -- 2.3 Structure and function of the microcirculation -- 2.4 Transcapillary exchange of solutes -- 2.5 Regulation of blood flow -- 2.5.1 Local regulation of blood flow -- 2.5.2 Mechanisms of local regulation -- 2.5.3 Myogenic mechanism -- 2.5.4 Metabolically linked mechanisms of blood flow regulation -- 2.5.4.1 Metabolic vasodilator hypothesis -- 2.5.4.2 Erythrocyte as a mobile oxygen sensor hypothesis -- 2.5.4.2.1 ATP release from RBCs -- 2.5.4.2.2 NO release from RBCs -- 2.5.4.3 Nitric oxide/superoxide radical pair interaction hypothesis -- 2.5.5 Other oxygen-linked issues of flow regulation -- 2.5.6 Conducted vasomotor responses -- 000786605 5058_ $$a3. The respiratory system and oxygen transport -- 3.1 Physical chemistry of respiratory gases -- 3.1.1 Gas laws -- 3.1.2 Properties of gases in liquids: Henry's law -- 3.1.3 Forms in which gases are carried -- 000786605 5058_ $$a4. Oxygen transport -- 4.1 Gas exchange and diffusion -- 4.1.1 Overall gas exchange -- 4.1.2 Diffusion -- 4.1.3 Fick's law of diffusion -- 4.1.4 Summary of diffusion properties -- 4.1.5 Gas exchange limited by diffusion and perfusion -- 4.2 Oxygen in the blood -- 4.2.1 Blood: plasma and red blood cells -- 4.2.2 Hemoglobin (heme + globin) -- 4.2.3 Binding of oxygen to hemoglobin: oxygen saturation (dissociation) curve -- 4.2.4 Allosteric effectors of oxygen binding to hemoglobin -- 4.2.5 Overall oxygen transport -- 4.2.6 Carboxyhemoglobin -- 4.3 Artificial oxygen carriers -- 4.3.1 Hemoglobin-based oxygen carriers -- 4.3.2 Perfluorocarbon emulsions -- 000786605 5058_ $$a5. Chemical regulation of respiration -- 5.1 Response to altered oxygen -- 5.2 Central and peripheral respiratory chemoreceptors -- 000786605 5058_ $$a6. Tissue gas transport -- 6.1 Utilization of oxygen by tissues -- 6.1.1 Mitochondria -- 6.1.2 Role of nitric oxide -- 6.1.3 Role of myoglobin in striated muscle -- 6.2 Oxygen transport in the microcirculation -- 6.2.1 Longitudinal (axial) profile of oxygen in arterioles -- 6.2.2 Longitudinal (axial) profile of oxygen in a capillary -- 6.2.3 Tissue oxygen transport: Krogh cylinder model -- 000786605 5058_ $$a7. Oxygen transport in normal and pathological situations: defects and compensations -- 7.1 Description of oxygen transport using Fick's principle -- 7.2 Stagnant hypoxia (hypoperfusion) -- 7.3 Hypoxic hypoxia -- 7.4 Anemic hypoxia -- 7.5 Histotoxic hypoxia -- 7.6 Summary of hypoxic conditions and responses -- 000786605 5058_ $$a8. Matching oxygen supply to oxygen demand -- 8.1 Fick's principle -- 8.2 Convective vs. diffusive oxygen transport -- 8.3 Matching oxygen supply to oxygen demand: role of arterioles and capillaries -- 8.4 Oxygen profile along a capillary: mass balance -- 8.5 Heterogeneity of blood flow and oxygen delivery -- 000786605 5058_ $$a9. Exercise and hemorrhage -- 9.1 Exercise -- 9.1.1 Fick's principle in exercise -- 9.1.2 Temporal phases of exercise -- 9.1.3 Microvascular approach to oxygen transport during muscle contraction -- 9.1.4 Limited oxygen release from red blood cells: effect of transit time -- 9.2 Hemorrhage -- 9.2.1 Fick's principle in hemorrhage -- 9.2.2 Compensatory mechanisms in hemorrhage -- 9.2.3 Circulatory shock and resuscitation -- 000786605 5058_ $$a10. Measurement of oxygen -- 10.1 Oxygen tension (PO2) -- 10.1.1 Polarographic electrodes -- 10.1.2 Phosphorescence quenching microscopy -- 10.2 Hemoglobin oxygen saturation (SO2) -- 10.2.1 Spectrophotometry of hemoglobin -- 10.2.2 Resonance Raman spectroscopy of hemoglobin -- 000786605 5058_ $$a11. Summary -- References -- Author biography. 000786605 506__ $$aAccess limited to authorized users 000786605 533__ $$aElectronic reproduction.$$bAnn Arbor, MI$$nAvailable via World Wide Web. 000786605 588__ $$aTitle from PDF title page (viewed on August 19, 2016). 000786605 650_0 $$aOxygen$$xPhysiological transport. 000786605 650_0 $$aTissue metabolism. 000786605 7102_ $$aProQuest (Firm) 000786605 77608 $$iPrint version:$$z9781615047208 000786605 830_0 $$aColloquium digital library of life sciences. 000786605 830_0 $$aColloquium series on integrated systems physiology ;$$v 65.$$x2154-5626 000786605 852__ $$bebk 000786605 85640 $$3GOBI DDA$$uhttps://univsouthin.idm.oclc.org/login?url=http://ebookcentral.proquest.com/lib/usiricelib-ebooks/detail.action?docID=4662060$$zOnline Access 000786605 909CO $$ooai:library.usi.edu:786605$$pGLOBAL_SET 000786605 980__ $$aEBOOK 000786605 980__ $$aBIB 000786605 982__ $$aEbook 000786605 983__ $$aOnline