000789674 000__ 05628cam\a2200529Mi\4500 000789674 001__ 789674 000789674 005__ 20230306143334.0 000789674 006__ m\\\\\o\\d\\\\\\\\ 000789674 007__ cr\un\nnnunnun 000789674 008__ 170603s2017\\\\sz\\\\\\o\\\\\001\0\eng\d 000789674 019__ $$a988293580$$a988386587$$a992485724$$a992888872 000789674 020__ $$a9783319545929$$q(electronic book) 000789674 020__ $$a3319545922$$q(electronic book) 000789674 020__ $$z9783319545905 000789674 020__ $$z3319545906 000789674 0247_ $$a10.1007/978-3-319-54592-9$$2doi 000789674 035__ $$aSP(OCoLC)ocn988872177 000789674 035__ $$aSP(OCoLC)988872177$$z(OCoLC)988293580$$z(OCoLC)988386587$$z(OCoLC)992485724$$z(OCoLC)992888872 000789674 040__ $$aEBLCP$$beng$$epn$$cEBLCP$$dGW5XE$$dN$T$$dOCLCQ$$dYDX$$dAZU$$dUAB$$dUPM$$dOCLCO$$dCOO$$dOCLCO 000789674 049__ $$aISEA 000789674 050_4 $$aRC112 000789674 050_4 $$aR1 000789674 08204 $$a616.907/54$$223 000789674 08204 $$a610 000789674 24500 $$aImaging infections :$$bfrom bench to bedside /$$cSanjay K. Jain, editor. 000789674 260__ $$aCham :$$bSpringer,$$c2017. 000789674 300__ $$a1 online resource (263 pages) 000789674 336__ $$atext$$btxt$$2rdacontent 000789674 337__ $$acomputer$$bc$$2rdamedia 000789674 338__ $$aonline resource$$bcr$$2rdacarrier 000789674 347__ $$atext file$$bPDF$$2rda 000789674 500__ $$aIncludes index. 000789674 5050_ $$aContributors; Chapter 1: Introduction; 1.1 Global Burden ofßInfectious Diseases; 1.2 Molecular Imaging; 1.3 The Problem; 1.4 The Solution; 1.5 Biocontainment; 1.6 Human Translation ofßPET Tracers; 1.7 Imaging Infections: FromßBench toßBedside; 1.7.1 Imaging inßtheßClinic; 1.7.2 Molecular Imaging Techniques; 1.7.3 Imaging Host Responses; 1.7.4 Pathogen-Specific Tracers; 1.7.5 Neuroimaging; 1.7.6 Antimicrobial Development; 1.7.7 Image Analyses; 1.7.8 Imaging inßtheßDeveloping World; 1.8 Summary; References; Chapter 2: Clinical Imaging; 2.1 Introduction; 2.2 Anatomical Imaging Tests. 000789674 5058_ $$a2.2.1 Computed Tomography2.2.2 Magnetic Resonance Imaging; 2.2.3 Ultrasonography; 2.3 Molecular Imaging Tests; 2.3.1 Nonspecific Agents; 2.3.1.1 Single-Photon-Emitting (SPECT) Radiopharmaceuticals; Gallium-67 Citrate; Labeled Leukocytes; 2.3.1.2 Positron-Emitting Radiopharmaceuticals; 18F-FDG; Other PET Radiopharmaceuticals; Gallium-68 Citrate; 2.3.2 Infection-Specific Agents; 2.3.2.1 SPECT Radiopharmaceuticals; Radiolabeled Antibiotics; 111In-Biotin; Radiolabeled Antimicrobial Peptides; 2.3.2.2 PET Radiopharmaceuticals; 2.4 Summary; References; Chapter 3: Optical Imaging; 3.1 Introduction. 000789674 5058_ $$a3.2 Bioluminescent Imaging3.3 Fluorescence Imaging; 3.4 Development ofßBioluminescent andßFluorescent Microorganisms; 3.5 Bacterial Imaging; 3.6 Fungal Imaging; 3.7 Parasite Imaging; 3.8 Viral Imaging; 3.9 Translation toßtheßClinic; 3.9.1 Bacterial Surface Probes; 3.9.2 Antibiotic Probes; 3.9.3 Bacteriophage andßAntibody Probes; 3.9.4 Metabolizable Probes; 3.9.5 Activatable Probes; 3.10 Photoacoustic Imaging; 3.11 Multimodality Imaging; 3.12 Photodynamic Therapy; 3.13 Conclusions andßFuture Directions; 3.14 Summary; References; Chapter 4: Radiochemistry; 4.1 Introduction; 4.2 Radionuclides. 000789674 5058_ $$a4.2.1 Iodine Radionuclides4.2.2 Carbon-11 (C-11, 11C); 4.2.3 Fluorine-18 (F-18, 18F); 4.2.4 Technetium-99m (Tc-99m, 99mTc); 4.2.5 Copper-64 (Cu-64, 64Cu); 4.2.6 Gallium-68 (Ga-68, 68Ga); 4.2.7 Gallium-67 (Ga-67, 67Ga); 4.2.8 Indium-111 (In-111, 111In); 4.3 Examples ofßInfection Imaging Agents; 4.3.1 67Ga-Citrate SPECT; 4.3.2 111In-Oxine-Leukocyte SPECT; 4.3.3 99mTc-HMPAO-Leukocyte-SPECT (CERETEC®); 4.3.4 18F-FDG PET; 4.3.5 99mTc-Sn-Colloid SPECT (Leukocyte®); 4.3.6 99mTc-MDP SPECT; 4.3.7 99mTc-Besilesomab SPECT (Scintimun®); 4.3.8 99mTc-Sulesomab SPECT (LeukoScan®). 000789674 5058_ $$a4.3.9 99mTc-Sulfur-Nanocolloids SPECT (Nanocoll®)4.4 Experimental Radiotracers forßInfection Imaging; 4.4.1 Synthetics andßBiomimetics; 4.4.2 Antibiotics; 4.4.3 Radiolabeled Cells; 4.4.4 Bacteria-Specific Sugars; 4.4.5 Macromolecules andßAntibodies; 4.4.6 Small Peptide Fragments; 4.4.7 Other Agents; 4.5 Summary; References; Chapter 5: Imaging theßHost Response; 5.1 Introduction; 5.2 Leukocyte Tracking; 5.2.1 [111In]Oxyquinoline andß[99mTc]HMPAO; 5.2.2 18F-2-Fluoro-Deoxy-d-Glucose (18F-FDG) Ex Vivo Labeling ofßLeukocytes; 5.2.3 Iron Oxide Nanoparticle Labeling andßT2-Weighted MRI. 5.2.4 19F-Labeled Perfluorocarbons andßMRI. 000789674 506__ $$aAccess limited to authorized users. 000789674 520__ $$aThis books brings together multi-disciplinary expertise to provide comprehensive information about molecular imaging of infectious diseases. Also described are the development of new imaging technologies for infectious disease and their translation to the clinic. The overall goal of Imaging Infections: From Bench to Bedside is to spur interest and innovation in this emerging field. We anticipate that these technologies will not only allow unique insights into understanding pathogenesis of infections but also expedite bench-to-bedside translation of new therapeutics. While molecular imaging is already in common use in the clinic, this book demonstrates how it could also become a valuable tool for clinical studies, patient care, public health, and for enabling precision medicine for infectious diseases. 000789674 588__ $$aDescription based on print version record. 000789674 650_0 $$aInfection$$xImaging. 000789674 7001_ $$aJain, Sanjay K. 000789674 77608 $$iPrint version:$$aJain, Sanjay K.$$tImaging Infections : From Bench to Bedside.$$dCham : Springer International Publishing, ©2017$$z9783319545905 000789674 852__ $$bebk 000789674 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-54592-9$$zOnline Access$$91397441.1 000789674 909CO $$ooai:library.usi.edu:789674$$pGLOBAL_SET 000789674 980__ $$aEBOOK 000789674 980__ $$aBIB 000789674 982__ $$aEbook 000789674 983__ $$aOnline 000789674 994__ $$a92$$bISE