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000790032 019__ $$a991707764$$a992486821$$a993961135
000790032 020__ $$a9789811043109$$q(electronic book)
000790032 020__ $$a9811043108$$q(electronic book)
000790032 020__ $$z9789811043093$$q(hardcover : alk. paper)
000790032 020__ $$z9811043094$$q(hardcover : alk. paper)
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000790032 08204 $$a572.8/8$$223
000790032 24500 $$aRNA activation /$$cLong-Cheng Li, editor.
000790032 264_1 $$aSingapore :$$bSpringer,$$c[2017]
000790032 264_4 $$c©2017
000790032 300__ $$a1 online resource :$$billustrations.
000790032 336__ $$atext$$btxt$$2rdacontent
000790032 336__ $$astill image$$bsti$$2rdacontent
000790032 337__ $$acomputer$$bc$$2rdamedia
000790032 338__ $$aonline resource$$bcr$$2rdacarrier
000790032 4901_ $$aAdvances in experimental medicine and biology,$$x2214-8019 ;$$vvolume 983
000790032 504__ $$aIncludes bibliographical references and index.
000790032 5050_ $$aSmall RNA-guided transcriptional gene activation (rnaa) in mammalian cells / Long-Cheng Li / Exogenous RNAa. Enhancing neuronogenesis and counteracting neuropathogenic gene haploinsufficiencies by RNA gene activation / Antonello Mallamaci -- Target-recognition mechanism and specificity of RNA activation / Huiqing Cao, Xing Meng, Xiaoxia Wang, Zicai Liang -- Promoter-targeted small activating rnas alter nucleosome positioning / Bin Wang, Yunzhang Hu -- Endogenous RNAa. Endogenous miRNAa: miRNA-mediated gene upregulation / Vera Huang -- Mirna-mediated RNA activation in mammalian cells / Ramani Ramchandran, Pradeep Chaluvally-Raghavan -- RNAa induced by tata box-targeting micrornas / Yijun Zhang, Hui Zhang -- miRNA-mediated RNAa by targeting enhancers / Qingping Zou, Ying Liang, Huaibing Luo, Wenqiang Yu -- RNA activation guided by other RNA.  specific increase of protein levels by enhancing translation using antisense oligonucleotides targeting upstream open frames / Xue-Hai Liang, Wen Shen, Stanley T. Crooke -- Repurposing CRISPR system for transcriptional activation / Meng Chen, Lei Stanley Qi -- Developing RNAa-based therapeutics. RNA-mediated gene activation: identifying a candidate RNA for preclinical development / David R. Corey -- Treatment of pancreatic cancer by aptamer conjugated C/EBP[alpha]-saRNA / Sorah Yoon, John J. Rossi -- Treatment of liver cancer by C/EBPA saRNA / Xiaoyang Zhao, Jon Voutila, Stephanos Ghobrial, Nagy A. Habib, Vikash Reebye -- Enhancing angiogenesis in mice by VEGF-targeting small activating RNAs / Tiia A. Turunen, Seppo Ylä-Herttuala, Mikko P. Turunen -- Suppression of prostate cancer metastasis by DPYSL3-targeted saRNA / Benyi Li, Changlin Li -- Development of therapeutic dsP21 for cancer treatment / Moo Rim Kang, Gongcheng Li, Tiejun Pan, Jin-Chun Xing, Long-Cheng Li.
000790032 506__ $$aAccess limited to authorized users.
000790032 520__ $$aThis book offers an essential guide to RNA activation (RNAa), an emerging and fascinating new field. RNAa is a small RNA-guided and Argonaute-dependent gene regulation phenomenon in which promoter-targeted short double-stranded RNAs (dsRNAs) induce target gene expression at the transcriptional level. It occurs primarily in the nucleus and can be mediated by artificially designed short duplex RNAs that target regulatory sequences (e.g., promoters, genes' 3' termini and enhancers) and naturally occurring small RNAs (e.g., miRNAs and C. elegans 22G-RNAs). With contributions from internationally respected RNA experts, this book provides comprehensive coverage of different RNAa mechanisms and a timely update on recent advances in RNAa research, with a focus on developing RNAa-based therapeutics. Special chapters are also devoted to the topics of gene activation induced by antisense oligonucleotides and the CRISPR system. As the first book to cover RNAa, it will be of interest to a wide audience, from scientists in academia and the pharmaceutical industry to clinicians who wish to further explore the biology of RNAa and related phenomena, so as to harness their full potential for use in biotechnology and drug development.
000790032 588__ $$aDescription based on online resource; title from resource home page (SpringerLink, viewed July 18, 2017).
000790032 650_0 $$aRNA.
000790032 650_0 $$aGene expression.
000790032 7001_ $$aLi, Long-Cheng,$$eeditor.
000790032 77608 $$iPrint version:$$tRNA activation$$dSingapore : Springer, [2017]$$z9789811043093$$w(OCoLC)973306606
000790032 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 983.$$x0065-2598
000790032 852__ $$bebk
000790032 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-981-10-4310-9$$zOnline Access$$91397441.1
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000790032 980__ $$aEBOOK
000790032 980__ $$aBIB
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000790032 983__ $$aOnline
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