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Preface; Acknowledgements; Contents; Part I: Problem Diagnosis: A General Overview of the Origins and Nature of Chemical Exposure Problems; Chapter 1: Introduction; 1.1 Chemical Origins: Coming to Terms with the Several Chemicals in Modern Society; 1.1.1 The Wide-Ranging Scope of Chemical Hazard Problems: A General Overview; 1.1.2 The Wide-Ranging Scope of Chemical Hazard Problems: Lead Exposures as an Example; 1.2 Public Health and Socio-Economic Implications of Chemical Exposure Problems; 1.2.1 The General Nature of Human Health Effects From Chemical Exposures
1.3 Strategically Managing the Chemical Exposure Problem: The Need for Public Health Risk AssessmentChapter 2: Anatomical and Physiological Perspectives on Human Exposure to Chemicals; 2.1 An Overview of Human Contact Sites and Target Organs Most Susceptible to Chemical Exposures; 2.1.1 Fundamentals of Human Physiology; 2.1.2 Target Organ Toxicity; 2.2 The General Nature of Chemical Hazards and Human Response from Exposure to Chemical Substances; 2.2.1 Classification of Chemical Toxicity; 2.2.2 Factors Influencing Chemical Toxicity to Humans and Human Response to Chemical Toxicants
Box 2.1 Factors Potentially Influencing Human Response to Toxic Chemicals2.2.2.1 Distribution and Storage of Toxicants in the Human Body; 2.2.2.2 Toxicokinetics/Pharmacokinetics vs. Toxicodynamics/Pharmacodynamics; 2.3 The Pharmacokinetics and Pharmacodynamics of Chemicals in Human Exposure Environments; 2.3.1 Elements of Toxicokinetics/Pharmacokinetics; 2.3.2 Physiologically-Based Pharmacokinetic (PBPK) Modeling; 2.3.3 Characterization of Physiologically-Based Pharmacokinetic (PBPK) Models; 2.3.3.1 PBPK Model Structure and Mechanics/Descriptors
2.3.3.2 Documenting PBPK Modeling Outcomes/Results2.3.4 Application/Use of Mechanistic Data and Physiologically-Based Pharmacokinetic (PBPK) Models in Risk Assessments; 2.3.5 Post-PBPK Modeling and Dosimetry Adjustments: The Pragmatic Role of Tissue/Target Organ Dosimetry in Risk Assessments; Chapter 3: Archetypical Chemical Exposure Problems; 3.1 Formulation of Archetypical Chemical Exposure Problems; 3.1.1 The Case for Human Exposures to Airborne Chemical Toxicants; 3.1.1.1 Indoor Air Quality Problems: General Sources of Indoor Volatile [Organic] Chemicals
3.1.1.2 Chemical Vapor Intrusion into Buildings3.1.2 Water Pollution Problems and Human Exposures to Chemicals in Water as an Example; 3.1.3 Contaminated Soil Problems and Human Exposures to Chemicals on Land; 3.1.4 Human Exposures to Chemicals in Foods and Household/Consumer Products; 3.2 Quantification Process for the General Types of Human Exposures to Chemical Toxicants; Part II: A Public Health Risk Assessment Taxonomy: Nomenclatural Components, Concepts, Principles, and Evaluation Strategies; Chapter 4: Principles and Concepts in Risk Assessment
1.3 Strategically Managing the Chemical Exposure Problem: The Need for Public Health Risk AssessmentChapter 2: Anatomical and Physiological Perspectives on Human Exposure to Chemicals; 2.1 An Overview of Human Contact Sites and Target Organs Most Susceptible to Chemical Exposures; 2.1.1 Fundamentals of Human Physiology; 2.1.2 Target Organ Toxicity; 2.2 The General Nature of Chemical Hazards and Human Response from Exposure to Chemical Substances; 2.2.1 Classification of Chemical Toxicity; 2.2.2 Factors Influencing Chemical Toxicity to Humans and Human Response to Chemical Toxicants
Box 2.1 Factors Potentially Influencing Human Response to Toxic Chemicals2.2.2.1 Distribution and Storage of Toxicants in the Human Body; 2.2.2.2 Toxicokinetics/Pharmacokinetics vs. Toxicodynamics/Pharmacodynamics; 2.3 The Pharmacokinetics and Pharmacodynamics of Chemicals in Human Exposure Environments; 2.3.1 Elements of Toxicokinetics/Pharmacokinetics; 2.3.2 Physiologically-Based Pharmacokinetic (PBPK) Modeling; 2.3.3 Characterization of Physiologically-Based Pharmacokinetic (PBPK) Models; 2.3.3.1 PBPK Model Structure and Mechanics/Descriptors
2.3.3.2 Documenting PBPK Modeling Outcomes/Results2.3.4 Application/Use of Mechanistic Data and Physiologically-Based Pharmacokinetic (PBPK) Models in Risk Assessments; 2.3.5 Post-PBPK Modeling and Dosimetry Adjustments: The Pragmatic Role of Tissue/Target Organ Dosimetry in Risk Assessments; Chapter 3: Archetypical Chemical Exposure Problems; 3.1 Formulation of Archetypical Chemical Exposure Problems; 3.1.1 The Case for Human Exposures to Airborne Chemical Toxicants; 3.1.1.1 Indoor Air Quality Problems: General Sources of Indoor Volatile [Organic] Chemicals
3.1.1.2 Chemical Vapor Intrusion into Buildings3.1.2 Water Pollution Problems and Human Exposures to Chemicals in Water as an Example; 3.1.3 Contaminated Soil Problems and Human Exposures to Chemicals on Land; 3.1.4 Human Exposures to Chemicals in Foods and Household/Consumer Products; 3.2 Quantification Process for the General Types of Human Exposures to Chemical Toxicants; Part II: A Public Health Risk Assessment Taxonomy: Nomenclatural Components, Concepts, Principles, and Evaluation Strategies; Chapter 4: Principles and Concepts in Risk Assessment