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Foreword; Preface; Contents; Contributors; 1: The Rising Incidence of Thyroid Cancer: Contributions from Healthcare Practice and Biologic Risk Factors; Introduction; Incidence of Thyroid Cancer; Increased Detection of Subclinical Disease; Biologic Risk Factors for Thyroid Cancer; Ionizing Radiation as a Risk Factor for Thyroid Cancer; Obesity, Estrogen, and the Metabolic Syndrome; Other Proposed Modulators of Thyroid-Stimulating Hormone and Thyroid Cancer Risk; References; 2: Molecular Genetics of Thyroid Cancer; Papillary Thyroid Cancer; BRAF; Genetics
Indication for Biopsy Pathology Reporting; References; 4: Pathologic Diagnosis of Thyroid Cancer; Introduction; Specimen Acquisition and Slide Preparation; Terminology for Reporting Thyroid Fine-Needle Aspiration; Class I: Nondiagnostic or Unsatisfactory; Class II: Benign; Class III: Atypia of Undetermined Significance or Follicular Lesion of Undetermined Significance; Class IV: Follicular Neoplasm or Suspicious for Follicular Neoplasm; Class V: Suspicious for Malignancy; Class IV: Malignant; Core-Needle Biopsy; The Role of Frozen Section Examination in Thyroid Disease
Surgical Pathology of Differentiated Thyroid Cancers Papillary Thyroid Carcinoma; FNA; Gross Examination; Microscopic Features; PTC Variants; Follicular Thyroid Carcinoma; Gross Examination; Microscopic Features; FTC Subtyping; Pitfalls; Limitations of FNA; Hyalinizing Trabecular Tumor; Thyroiditis; Intrathyroidal Parathyroid; Endocrine Atypia; References; 5: Molecular Diagnostic Approaches and Their Clinical Utility; Introduction; Afirma Gene Expression Classifier (GEC); Test Characteristics; Clinical Validity; Clinical Applicability; Future Direction
Gene Mutation Panels Test Characteristics; Clinical Validity; Clinical Utility; Clinical Applicability; Future Horizons; Next-Generation Sequence Panel; Test Characteristics; Clinical Validity; Clinical Utility; Future Directions; References; 6: Clinical Presentation and Diagnosis of Papillary Thyroid Cancer; Introduction; The Incidence of Thyroid Cancer Is Rising; What Are the Risk Factors for Developing PTC?; Demographics and Epidemiology of Thyroid Cancer; Family History; Radiation History; Nodular Goiter; Evaluation of Patients with a Thyroid Nodule
Indication for Biopsy Pathology Reporting; References; 4: Pathologic Diagnosis of Thyroid Cancer; Introduction; Specimen Acquisition and Slide Preparation; Terminology for Reporting Thyroid Fine-Needle Aspiration; Class I: Nondiagnostic or Unsatisfactory; Class II: Benign; Class III: Atypia of Undetermined Significance or Follicular Lesion of Undetermined Significance; Class IV: Follicular Neoplasm or Suspicious for Follicular Neoplasm; Class V: Suspicious for Malignancy; Class IV: Malignant; Core-Needle Biopsy; The Role of Frozen Section Examination in Thyroid Disease
Surgical Pathology of Differentiated Thyroid Cancers Papillary Thyroid Carcinoma; FNA; Gross Examination; Microscopic Features; PTC Variants; Follicular Thyroid Carcinoma; Gross Examination; Microscopic Features; FTC Subtyping; Pitfalls; Limitations of FNA; Hyalinizing Trabecular Tumor; Thyroiditis; Intrathyroidal Parathyroid; Endocrine Atypia; References; 5: Molecular Diagnostic Approaches and Their Clinical Utility; Introduction; Afirma Gene Expression Classifier (GEC); Test Characteristics; Clinical Validity; Clinical Applicability; Future Direction
Gene Mutation Panels Test Characteristics; Clinical Validity; Clinical Utility; Clinical Applicability; Future Horizons; Next-Generation Sequence Panel; Test Characteristics; Clinical Validity; Clinical Utility; Future Directions; References; 6: Clinical Presentation and Diagnosis of Papillary Thyroid Cancer; Introduction; The Incidence of Thyroid Cancer Is Rising; What Are the Risk Factors for Developing PTC?; Demographics and Epidemiology of Thyroid Cancer; Family History; Radiation History; Nodular Goiter; Evaluation of Patients with a Thyroid Nodule