Foreword; Preface; Contents; Contributors; Introduction; Chapter 1: The Natural History of Breast Cancer; 1.1 Introduction; 1.2 The Nature of Models and Models of Nature; 1.2.1 The Natural History of a Rose; 1.2.2 Breast Cancer; 1.2.3 Breast Cancer in the Nineteenth Century and Early Twentieth Century; 1.2.4 The Influence of Surgery on the Natural History of Breast Cancer; 1.2.5 The Biological Revolution of the Late Twentieth Century; 1.2.6 Phenomena that Challenge the Existing Models; 1.2.6.1 Local Treatment; 1.2.7 Adjuvant Systemic Therapy Has Only a Modest Effect on Survival

1.2.8 When Does a Primary Tumour Seed Its Secondaries?1.2.9 A new Model to Explain the Natural History of Breast Cancer; 1.2.10 The Nature of Beauty and the Beauty of Nature; References; Chapter 2: Perioperative Inflammation as Triggering Origin of Metastasis Development; 2.1 Introduction; 2.2 Milan Data Showing Early Bimodal Relapse Pattern That Started This Investigation; 2.3 Multipeak Relapse Data Suggest Continuous Growth Is Not a Correct Description of Spontaneous Cancers; 2.4 Library Research at University of Texas-San Antonio; 2.5 Ingleby and Moore Data

2.6 It Seems We Have Rediscovered a Problem That Was Known to Surgeons 2000 Years Ago2.7 Clinical Correlations to Suggested Surgery Induced Metastatic Activity; 2.8 Surprising Development from a Belgian Anesthesiology Group; 2.9 Our Attention Is Drawn to Inflammation; 2.10 Possible Mechanisms for a Post-surgical Systemic Inflammatory Reaction to Drive Tumor Growth; 2.11 TNBC and Early Relapses: Possibly an Ideal Group for Testing Perioperative Ketorolac; 2.12 Current Activities; 2.12.1 Focus on India and Nigeria; 2.13 Analysis of Data from Norway on Relapse Hazard After Delayed Reconstruction

3.4 Comparative Analysis of Angiogenesis-Related Genes in Patients with Breast Cancer (Study Group) Before Surgery (PRO) and on Post-operative Day 3 (D3)3.5 Comparative Analysis of Angiogenesis-Related Genes in Patients with Breast Cancer (Study Group) Between Post-operative Day 3 (D3) and Post-operative Day 7 (D7); 3.6 Conclusions; References; Chapter 4: Perioperative Biologic Perturbation and Cancer Surgery: Targeting the Adrenergic-Inflammatory Response and Microcirculatory Dysregulation; 4.1 Introduction; 4.2 Importance of the Perioperative Period to Cancer Outcomes.